Mahalo nui loa for your support of Bishop Museum and the work that we do to connect our community with the stories we share about Hawaiʻi and the Pacific. When the Museum as founded in 1889, along wi...

Understanding to Some Purpose

Research video Authors: César Flores López, Natsuko Rivera-Yoshida, Alejandro V. Arzola, Adrian Arturo Huerta Hernández, and Mariana Benítez

Capacity building of conceptual, theoretical, and empirical resources to facilitate new research configurations across disciplines and foster novel investigative strategies that advance life science…

Philosopher Alan Love on why ‘do I have purpose?’ is the wrong question to ask yourself. ❍ Subscribe to The Well on YouTube: https://bit.ly/welcometothewell Does life have a purpose? Philosopher…

A deep dive into several species of Indo-Pacific fangblenny

Pay Range: Targeted salary $18.99 per hour, based on experience Benefits Eligible: Yes Work Schedule: Monday – Friday, 8:00 a.m. to 5:00 p.m. (may include some weekends) Travel: May be required For Be...

The κ-opioid receptor (κOR) represents a promising non-addictive analgesic target due to its critical role in pain and reward pathways. Despite evidence of κOR dimerization, its molecular basis and pharmacological significance remain elusive. Here, we demonstrate stable κOR dimer formation in living cells and present cryo-electron microscopy structures of salvinorin A-bound κOR dimer complexed with two Gi proteins, revealing a parallel assembly distinct from previously characterized GPCR dimers that engage only single G protein. Multiple membrane lipids are positioned at the TM1-Helix 8 interface, where they make extensive contacts with both protomers and may contribute to the stability of the κOR dimer. Importantly, dimerization significantly enhances Gi protein recruitment to κOR in both potency and efficacy. We also demonstrate that salvinorin A, a non-nitrogenous agonist, binds similarly in monomeric and dimeric κOR, and identify Y3127.35 as a critical selectivity determinant acros

Hybridization amongst teleost fish species is an ongoing phenomenon with unclear implications Chrosomus eos, the Northern Redbelly Dace, is a species with an especially complex and fascinating history...

Peripheral and disjunct populations are often the result of historic geological changes in the landscape and because of the long temporal span of colonization or vicariance, they are often genetically...

Abstract. Evolutionary “fitness” is operationalized in many different ways in models. Its role is to quantify that which is favored by natural selection. G

Cougars were native to Minnesota before becoming extinct within the state, according to the DNR. Over the past two decades, there have been dozens of sightings of lone cougars across Minnesota.

The repeated evolution of parental care is often accompanied by shifts in the neural circuits and hormonal pathways that regulate motivation and aggre…

The skipjack herring Alosa chrysochloris inhabits Gulf of Mexico drainages, primarily the Mississippi River Basin, and estuarine environments in the Gulf of Mexico. The trophic ecology of the skipjac...

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Two weeks after Alex Pretti’s killing, federal agents have shown no signs of backing down. The resistance definitely hasn't.

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