Progesterone is a critical reproductive hormone that acts via progesterone receptor transcriptional regulators. The short PGR-A isoform lacks a 164–amino acid amino-terminal region present in PGR-B th...

 By pairing two neural networks in an iterative optimization algorithm, small-molecule binding proteins can be designed from scratch with high accuracy, affinity and success rates, showing p...

A study confirms the vaccine gives excellent protection for babies against life-threatening chest infections.

Can you squeeze your graduate programme into a 40-hour working week? These 13 current and former PhD candidates reveal their top time-management tips.

Biomining uses engineered microbes to harvest critical minerals

Crystalline materials for optical applications are synthesized in living dinoflagellates.

“Society grows great when old men plant trees whose shade they’ll never sit under.” There’s an inverse to that wisdom. Great societies decline when old men chop down forests meant to provide shade and...

The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...

Simons Postdoctoral Fellowships in Plant Biology on Simons Foundation

Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed...

OR: Borg vibes

Large genome databases have markedly improved our understanding of marine microorganisms. Although these resources have focused on prokaryotes, genomes from many dominant marine lineages, such as Pela...

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In decades of deep-sea exploration, humans have observed only 0.001% of the deep seafloor, leaving 66% of planet Earth unseen.

A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods. Single-particle cryo-EM reve...

Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

ALT: a picture of a pikachu with the words " i still have hope " written below it

OR: How to eat fewer asparagus beetles

Neurodiversity and innovation often go hand in hand, but does that mean visionary entrepreneurs get a free pass to say and do anything they want? Bonobos founder and mental health advocate Andy Dunn s...

HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, ar...

Infected people described as having flu-like symptoms including high fever and severe headaches

Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?