Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10–15%.

A large-scale photonic accelerator comprising more than 16,000 components integrated on a single chip to process MAC operations is described, demonstrating ultralow latency and reduced computing time compared with a commercially available GPU.

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of 7 years by approximately one-fifth.

Polar bears are able to minimize ice accumulation thanks to their hair oil.

Experiments suggest that an unusual magnetic material can help harness energy from the planet’s rotation. But not everyone is convinced.

Nature - The device, to be tested in more people, could be used as a temporary measure for those waiting for a donor organ.

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Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...

Analysis pokes holes in protocol that underpins Microsoft’s claim to have created the first topological qubits.

Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...

Retinoic acid is known to be effective against bone marrow metastatic neuroblastoma cells, but not primary tumors. Here, authors discover that bone morphogenetic protein signaling is responsible for d...

Find new research showing how retinoic acid hijacks a developmental pathway in metastasized neuroblastoma in the bone marrow, solving a 50 year-long mystery.

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.

Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts...

Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...

Although hypoxia is often pathologic, chronic continuous hypoxia has shown promise in many disease models, inspiring a roadmap for clinical translation.

‘Lab vans’ and other facilities can bring researchers closer to what they study.

Liu et al. develop CSI-GEP, an algorithm for recovering gene expression programs (GEPs) from single-cell RNA-seq data. GEPs can correspond to cell types or the activity of biological processes. CSI-GEP provides a better model for single-cell RNA-seq data compared to hard clustering. It outperforms existing methods in simulated and real data.

Despite extensive mapping of cis-regulatory elements (cREs) across cellular contexts with chromatin accessibility assays, the sequence syntax and genetic variants that regulate transcription factor (T...

Programmable Enrichment via RNA FlowFISH by sequencing (PERFF-seq) isolates rare cells based on RNA marker transcripts for single-cell RNA sequencing profiling of complex tissues, with applicability t...