Cancer cells are greedy for glutamine. Our amazing collaborators show how CRISPR-guided metallohelices can help redirect this nutrient away from tumour cells and towards immune cells, boosting dendritic cell activation and strengthening anti-tumour T cell responses. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Regulation of Tumor-Immune Cell Communications via Enantioselectively Targeting SLC G-Quadruplexes
Compelling evidence shows that amino acids can influence tumor-immune cell communication. Their transfer across the plasma membrane involves multiple amino acid transporters within the solute carrier ...