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RSC Medicinal Chemistry @rscmedchem.rsc.org · 30/09/2026

🔓Be sure to read #OpenAccess research by Christian Melander & co. from @notredame.bsky.social & @univofmaryland.bsky.social in our latest issue generating sorafenib analogues that exhibit dual Colistin-potentiating and anti-MRSA activity #medchem Find it in full here🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 28/09/2026

Don't miss the Review behind the inside front cover of our latest issue by Ranjana Pathania et al. from IIT Roorkee discussing AI-enabled discovery of small molecule β-lactamase inhibitors to overcome enzyme diversity and resistance evolution #medchem doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 24/09/2026

📢Our latest issue is now online! 🔓Check out the #OpenAccess Review behind the cover by Ellen E. Hyde & @andrewbeekman.bsky.social from @uniofeastanglia.bsky.social looking at protein–protein interaction inhibitors in the human proteome #medchem doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 21/09/2026

Take a look in our latest issue at research by Kanaka Hettiarachchi & co. describing an integrated platform for accelerating therapeutic macrocyclic peptide purification in high-throughput medicinal chemistry #medchem 📍Merck & Co. doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 18/09/2026

Be sure to read a review from Zahoor Ahmad et al. at CSIR-IIIM in our latest issue looking at strategies for designing polypharmacological agents against multi-drug-resistant tuberculosis #medchem Find the full article on our website🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 16/09/2026

🔓Don't miss #OpenAccess research by Elena Cichero & co. from University of Genoa probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays #medchem Check it out in full below👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 14/09/2026

Check out research in our latest issue from Qidong You, Lei Wang et al. at China Pharmaceutical University reporting the discovery of DDO-4279 as a PP5 degrader for the treatment of obesity #medchem Read the full paper here🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 11/09/2026

Take a look at this Opinion article by Matthew W. D. Perry & Rhona J. Cox in our latest issue describing a game to communicate the iterative optimisation of multiple parameters in medicinal chemistry to wider audiences #medchem 📍 @astra-zeneca.bsky.social doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 09/09/2026

Be sure to read in our latest issue a paper from Héctor R. Morbidoni, Guillermo R. Labadie & co. at IQUIR-CONICET exploring the antimycobacterial profile of N-alkyl imidazoles #medchem Find it in full on our website🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 07/09/2026

Don't miss this research by Bahaa G. M. Youssif et al. from Assiut University in our latest issue developing a series of novel methylene disalicylic acid derivatives targeting DNA gyrase and topoisomerase IV #medchem Check out their full report below👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 04/09/2026

Check out this review from Nicholas S. O'Brien & Adam McCluskey at the University of Newcastle providing an overview of the last twenty years of quinazolines as tubulin polymerisation inhibitors #medchem Read the full article here🔽 doi.org/10.1039/d5md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 02/09/2026

📢We’re excited to announce that nominations for our 2027 Emerging Investigator Lectureship are open Details about how to nominate: www.rsc.org/standards-an... We’re looking for up-and-coming researchers in drug discovery within 12 yrs of their PhD. Nominate before 2 November! #chemsky #medchem 🧪

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 31/08/2026

🔓Take a look at #OpenAccess research in our latest issue by Zsolt Szakonyi et al. on the synthesis, molecular modelling and evaluation of (−)-isopulegol-based 2,4-diaminopyrimidines as aurora kinase inhibitors #medchem 📍University of Szeged, Vietnam National University doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 28/08/2026

Be sure to read this review by Cong-Jun Liu & co. from Zhengzhou University of Technology in our latest issue discussing strategic selection of linker attachment points in PROTACs #medchem Find the full article on our website👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 26/08/2026

📢We are delighted to announce our #OpenCall for papers to our Covalent Inhibitors & Probes themed collection #chemsky #medchem Guest Editors: @lynjoneschembio.bsky.social, Brian Lanman & Hannah Stewart Deadline: 31st January 2027 Find out more🔽 www.rsc.org/publishing/j...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 24/08/2026

Don't miss this research in our latest issue from Zhengqiang Wang et al. @univofminnesota.bsky.social & @tamu.bsky.social reporting 3-hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase inhibitors #medchem Check it out in full here🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 21/08/2026

📢Our latest issue is now online! 🔓Check out the #OpenAccess review behind the cover by Mayasah Al-Nema & co. from University of British Columbia discusseingrecent applications of computational techniques in the discovery of flavivirus inhibitors #medchem doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 19/08/2026

We are delighted to be co-chairing the AI in Medicinal Chemistry track at ELRIG Drug Discovery 2026 at ExceL London on 14-15 October! #ELRIGDD26 Looking forward to hearing the latest work in this exciting area of drug discovery. Don't miss your chance to attend with free registration bit.ly/4aSqgXA

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 17/08/2026

Be sure to read research from Rajnish Kumar, Shashikala Verma, Arunava Manna et al. at Banaras Hindu University in our latest issue describing novel complex naphthalimide–ciprofloxacin hybrids as antimicrobial agents #medchem Find it in full below🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 14/08/2026

🔓Don't miss this #OpenAccess review in our latest issue by Li-Ping Bai & co. from Macau University of Science and Technology discussing the recent advances in piperine and its derivatives as potential anticancer agents #medchem Check out the full article on our website👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 12/08/2026

Check out research from Ahmed M. El-Saghier et al. at Sohag University in our latest issue on the development of novel sulfonamide-embedded 1,2,4-triazinone derivatives in TGF-β-activated hepatic stellate cells #medchem Read it in full here🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 10/08/2026

🔓Take a look in our latest issue at research by Céline Olivier, Samir Amrane & co. reporting a new class of G-quadruplex ligands with anti-HIV-1 properties #medchem 📍 @univbordeaux.bsky.social doi.org/10.1039/d5md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 07/08/2026

🔓Be sure to read #OpenAccess research from Arun K. Ghosh et al. @purduechemistry.bsky.social in our latest issue describing novel SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands #medchem Find it in full here👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 05/08/2026

Don't miss research in our latest issue from Hongyan Li, Hongzhe Sun & co. at the University of Hong Kong showcasing the use of a bismuth drug as an antibiotic adjuvant to inhibit biofilm formation #medchem Check it out on our website🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 03/08/2026

🔓Check out this review by Celine Cano et al. from @newcastleuni.bsky.social in our latest issue providing insights into the discovery and optimisation of DNA-PK inhibitors #medchem Read the full article below👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 31/07/2026

Take a look in our latest issue at research from Toshio Morikawa, Genzoh Tanabe & co. investigating the structure activity relationship of the indole 2-S-,3-O-bis-glucoside calanthoside #medchem 📍Kindai University doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 29/07/2026

Be sure to read this review from Zihao Liu & Zhiguang Yang at Jilin University in our latest issue discussing the progress of histone deacetylase-based dual inhibitors in non-small cell lung cancer therapy #medchem Find their full article on our website👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 27/07/2026

🔓Don't miss #OpenAccess research in our latest issue by Ioannis K. Kostakis & co. from the University of Athens reporting novel hydroxytyrosol esters as potential anti-amyloid and neuroprotective agents for Alzheimer's disease #medchem Check it out in full here🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 24/07/2026

📢Our latest issue is now online! Check out the research behind the cover by Oleksandr O. Grygorenko & co. from Enamine & University of Kyiv describing the structure–activity relationships in a series of dihydrouracil–JQ1 conjugates #medchem doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 20/07/2026

Be sure to read this review by Mahdi Gallala et al. from Monastir University in our latest issue discussing the recent advances in the development of acridine-based hybrids with antiproliferative activity #medchem Find their full article below👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 17/07/2026

🔓Don't miss this #OpenAccess research in our latest issue from @danielecastagnolo.bsky.social & co. @ucl.ac.uk & @kingscollegelondon.bsky.social describing light-controlled inhibition of Gram-positive bacteria by photoswitchable amphiphilic lipids #medchem Check it out here🔽 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 15/07/2026

Take a look at this review from Yan Li, Honghua Zhang & co. in our latest issue looking at small-molecule therapeutics for diabetic retinopathy #medchem 📍National University of Singapore & Lanzhou University doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 13/07/2026

Be sure to read this paper in our latest issue by Srikanta Patra, Debasis Manna et al. at IIT Guwahati & IIT Bhubaneswar addressing multidrug-resistant bacterial infections with iridium-based theragnostic agents #medchem Find it in full below👇 doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 10/07/2026

🔓Don't miss in our latest issue #OpenAccess research by Gonzalo Rodriguez-Berriguete, Christopher J. Schofield, Geoff S. Higgins & co. @ox.ac.uk reporting structure-guided optimisation of fenofibrate-derived oxidative phosphorylation inhibitors #medchem Check it out here🔽 doi.org/10.1039/d5md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 08/07/2026

Check out this review by Fengxia Sun, Yunfei Da et al. from Tianjin University in our latest issue discussing the targets, pharmacological properties and SAR studies of sulfone and sulfoxide-containing pharmaceuticals #medchem Read it in full on our website🔽 doi.org/10.1039/d5md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 06/07/2026

Take a look in our latest issue at research by Patrícia Dias Fernandes & co. reporting new terpenyl–cinnamoyl–hydrazone analogues of cannabidiol with potent antinociceptive effect #medchem 📍 @ufrjoficial.bsky.social & @unifalmg.bsky.social doi.org/10.1039/d6md...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 01/07/2026

🔓Don't miss this #OpenAccess review in our latest issue by Martin R. Gill from Swansea University discussing the mechanisms and therapeutic implications of the relationship between Ruthenium(ii) polypyridyl complexes and the DNA damage response #medchem Check it out in full🔽

doi.org

Ruthenium(II) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

Ruthenium(ii) polypyridyl complexes (RPCs) have generated substantial interest due to their biomolecular binding capabilities, favourable photophysical properties, and anticancer activity. DNA is…

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 29/06/2026

🎉We were delighted to have @fleurmferguson.bsky.social's 2026 RSC Medicinal Chemistry Emerging Investigator Lectureship presented at the Induced Proximity Modalities & Therapeutics GRC this month! A huge congratulations to Fleur again on being selected for this year's Lectureship #chemsky #medchem

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 25/06/2026

📢Our latest issue is now online! Check out the article behind the cover by Nikolai Petrovsky, Janardhan Banothu & co. at NIT Calicut & Panjab University describing bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as TLR2 agonists #medchem pubs.rsc.org/en/content/a...

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 19/06/2026

Be sure to read a paper by Lei Wang, Engin U. Akkaya et al. from the Dalian University of Technology in our latest issue reporting hypoxia-triggered dichloroacetate delivery with effective reversal of cancer cell reprogramming #medchem Find the full article here🔽

pubs.rsc.org

Hypoxia-triggered dichloroacetate delivery with effective reversal of cancer cell reprogramming

Dichloroacetate (DCA) is a known inhibitor of pyruvate dehydrogenase kinase, which is part of the key enzyme complex in metabolic reprogramming of cancer cells. In this work, we structurally modified…

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Reposted by RSC Medicinal Chemistry

Royal Society of Chemistry @rsc.org · 17/06/2026

We're excited to announce the winners of our 2026 RSC Prizes! More than 60 talented individuals and teams from around the globe are being celebrated today for their work on everything from solar energy and drug discovery to materials chemistry and AI. 👉 rsc.li/3SgSapw #RSCPrizes #ChemSky

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 08/06/2026

Don't miss this review from Fule Wu, Muneeb Ur Rehman, Sihui Long et al. at the Wuhan Institute of Technology in our latest issue providing a holistic view of the pharmacological landscape of carbolines #medchem Check it out on our website🔽

pubs.rsc.org

Pharmacological landscape of carbolines: a holistic view

Natural resources have served as a cornerstone for the discovery of innovative pharmaceutical compounds for millennia. Among the diverse natural compounds demonstrating significant pharmacological…

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