The TIM barrel is nature’s most versatile enzyme fold, yet de novo variants lack functional active sites. Minimal de novo TIM barrels have now been converted into enzymes by designing structural lids ...

Un rassemblement est organisé à Metz après le décès d’un jeune homme de 19 ans victime d’une agression violente.

Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

This study demonstrates that enzymatic degradation of polybutylene terephthalate (PBT) can be achieved by tuning PBT's semicrystalline properties and incubation conditions. Polymers with a high conte....

The enzymatic degradation of polyethylene terephthalate (PET) offers a sustainable solution for PET recycling. Over the past two decades, more than 100 PETases have been characterized, primarily exhi...

PDB-101: Training, Outreach, and Education portal of RCSB PDB

Proteins, RNA, and DNA are central to virtually all cellular processes, often assembling into macromolecular complexes to perform their functions. While these molecules are inherently dynamic, most me...

Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold

Extreme morphological disparity within Mollusca has long confounded efforts to reconstruct a stable backbone phylogeny for the phylum. Familiar molluscan groups—gastropods, bivalves, and cephalopods—e...

La Loi de Finances 2025 validée le 03 février 2025 par l’utilisation de l’article 49.3 de la constitution par le gouvernement inclut un amendement visant à modifier l'article 293b du Code Général des ...

Before the 1960s, almost everything about living openly as a lesbian, gay, bisexual (LGB) person was illegal. The Stonewall Uprising on June 28, 1969 is a milestone in the quest for LGB civil rights a...

YouTube video by Clockwork

PLACER is graph neural network for local prediction of protein-ligand conformational ensembles. - baker-laboratory/PLACER

Millisecond-scale molecular dynamics simulations of 12 proteins reveal a set of common principles for protein folding.

Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de n...

You may have seen a recent pre-print [1] from Jain et al. with strongly worded claims against the experimental results in our DiffDock paper [2].

Alt: a man with long blonde hair and a beard is holding a fishing rod