2026年11月16日-19日召开会议，2026年11月13日报名截止

By uncoupling tumor immunogenicity from cell death, chemically well-defined platinum(IV)–antibody conjugates unlock strong synergy with anti-PD-1 and hig

Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19...

Nature Immunology - CD4+ T cells migrate from the gut and adipose tissue to the brain parenchyma, in mouse and human, transmitting information on diet and microbiome to the subfornical organ,...

Nature Communications - Tracking biomolecules in living cells requires fast but gentle labeling. Here, authors introduce inCu-click, a DNA-conjugated ligand that localizes copper to enable...

Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions in myeloid-derived suppresso...

Underlying many investments are breakthroughs in medicine and technology from great universities.

Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...

Nature Communications - Binding modes of antigenically drifted hemagglutinins of human influenza A viruses have been determined by NMR using synthetic N-glycans having 13C-labeled monosaccharides...

The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...

NIH officials said they were given no advance warning and less than an hour to post the memo publicly.

The Trump administration hobbles research and endangers the public health.

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

Disclosures. No relevant conflicts of interest to declare.

IL-33 induces tertiary lymphoid structures.

Immunoglobulin G (IgG) N-glycans have been identified as associated with aging; however, previous studies predominantly quantified changes based on the relative percentages of each glycan within the t...

Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosi...

A computational deep learning approach is used to design synthetic proteins that target the neosurfaces formed by protein–ligand interactions, with applications in the development of new therapeutic m...

Genetic deletion of EZH2 is detrimental to T-cell function. In contrast, the authors show that transient EZH2 inhibition during T-cell activation prior to the phenotypic onset of exhaustion enhances T...

A sugar auxiliary group assisted chain-elongation strategy was developed to overcome the limitation of bacterial β1–4-N-acetylgalactosaminyltransferase CjCgtA for the enzymatic synthesis of extended ....

This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...

Qiu et al. identify that reduced mannose metabolism is a key characteristic of T cell dysfunction. Enhancing mannose metabolism in T cells through D-mannose supplementation boosts anti-tumor activity, limits exhaustion differentiation, and maintains T cell stemness. Mechanistically, D-mannose promotes the OGT-mediated O-GlcNAcylation and stabilization of β-catenin, enhancing T cell stemness.

Proton sponge nano-assembly (PSNA) is optimized with self-assembly dependent fluorescence, positive charge density, and cell cytotoxicity. PSNA triggers immunogenic cell death (e.g., pyroptosis and n...

Multiple cell types, molecules, and processes contribute to inhibition of anti-tumor effector responses, often frustrating effective immunotherapy. Among these, Foxp3+ CD4+ cells (Tregs) are well-reco...

The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central to adaptive immunity, enabling responses against infections and cancer. The recent approval of TCR-...

A strategy pioneered during the Cold War may prevent people from believing and sharing online falsehoods

A triple orthogonal linker (T-Linker)-based programmable platform enables integration of therapeutic modules into multimodal targeting chimeras (Multi-TACs) for tumor-targeted co-engagement of differe...