iiinova — where your digital self keeps evolving

Reposted by Jonathan Keats, PhD 🇨🇦

The Canadian Cancer Trials Group @cctg.bsky.social · 25/09/2026

Congratulations to Dr. Nizar Bahlis (U of Calgary) who is the 2026 recipient of the International Myeloma Society Anderson Award. A well deserved honour that reflects his impact on Myeloma care. #IMS26

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 16/09/2026

Is there soap on the in Phoenix, rare day of rain but weird wispy white stuff on the road

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Reposted by Jonathan Keats, PhD 🇨🇦

Clara Jeffery @clarajeffery.bsky.social · 30/08/2026

Fuck you Google. We will all remember your capitulation to a mad king

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Reposted by Jonathan Keats, PhD 🇨🇦

WutTheWut😵‍💫 RBroeck🗳️💙 @wutthewut.bsky.social · 29/08/2026

Believe the science. It is literally written in stone. Vaccinate.

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Reposted by Jonathan Keats, PhD 🇨🇦

Matt Holt @holtjma.bsky.social · 27/08/2026

Our article introducing Aardvark for variant benchmarking is now published in Genome Biology! “Aardvark: sifting through differences in a mound of variants” DOI: doi.org/10.1186/s130... GitHub: github.com/PacificBiosc... Follow along for some highlights… 1/N

doi.org

Client Challenge

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Reposted by Jonathan Keats, PhD 🇨🇦

Krista Koeller @kristalerista.bsky.social · 28/07/2026

Thinking about how plants and animals, who independently evolved multicellularity, both landed on the spatial expression of transcription factors as the way to figure out where all the parts go.

A diagram showing the MADS domains patterning a flower. Gene expression goes from the outside in with A,B,C,D, and E domains. E is expressed in all cells. In some cells, there is A and E expression, those cells develop into sepals. Cells with A, B, and E expression become petals. Those with B, C, and E become stamens. Those with C and E become carpals, and C, D, and E cells become ovules.

Hox gene expression in the fly. The genes are shown in order on the chromosome and appear in the same order in the fly. The first gene patterns the mouth, the second the forehead, the third, the back of the head, etc.

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 22/07/2026

Sitting at the airport in Salt Lake City, some lady is leading a call for the Nevada elections and keeps saying, “I’m in California” wondering does she not know where she is or doesn’t want to say she is in Utah?

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Reposted by Jonathan Keats, PhD 🇨🇦

ContempraInn 🌹 @contemprainn.bsky.social · 19/07/2026

Glacier water in Argentina 🇦🇷 6,720 m above sea level.

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Reposted by Jonathan Keats, PhD 🇨🇦

Domestique @domestiquecycling.com · 13/07/2026

When your hotel during the 🇫🇷 Tour de France is so questionable that sleeping on the balcony feels like the better option 😅 🇳🇴 Anders Halland Johannessen and 🇳🇴 Tobias Halland Johannessen (Uno-X Mobility)

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Reposted by Jonathan Keats, PhD 🇨🇦

Brett Coughlin @coughlinbrett.bsky.social · 03/07/2026

Kylian Mbappé #WorldCup

Kylian Mbappé speaking about the destructive nature of sports gambling.

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Reposted by Jonathan Keats, PhD 🇨🇦

Nils Homer @nilshomer.com · 28/06/2026

🚀 new bwa-mem3 is out. Why use it? - 🏛️keep using a bwa-mem variant (avoid revalidation/reprocessing) - 🚅 1.7x faster/20% less memory than bwa-mem2 - 🧬native methylation support (asymmetric scoring) - ✅ matches bwa-mem2 output - 👊opt-in knobs to go even 2x faster bwa-mem3.readthedocs.io/en/latest/

bwa-mem3.readthedocs.io

Home - bwa-mem3

Accelerated short-read alignment, derived from bwa-mem2

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 20/06/2026

Cause I didn’t know about it till today. Appreciate all the work you and the FG team do!

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 20/06/2026

I’ve seen the northern light many times growing up but this is an amazing perspective

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Reposted by Jonathan Keats, PhD 🇨🇦

Charlotte Clymer @charlotteclymer.bsky.social · 29/05/2026

In case you missed it: last night, CBS News awarded the Mike Wallace Memorial Scholarship to Santiago Campos, a high school journalist. In accepting, he took the time to condemn the direction of CBS News to much surprise and applause from the audience.

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 07/05/2026

After largely running our clinical whole genome sequencing test for #myeloma, JAYseq, in stealth mode for the last 6 months I am extremely proud to see the culmination of years of research effort by my team at TGen and collaborators around the world come to fruition in a clinical test.

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Reposted by Jonathan Keats, PhD 🇨🇦

Space @redditspaceviewes.bsky.social · 23/04/2026

NASA releases insane new image of the mighty hexagonal storm on Saturn's North Pole.

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Reposted by Jonathan Keats, PhD 🇨🇦

Crystal Lewis @cghlewis.bsky.social · 15/04/2026

For those who still work with SPSS files, but want to import them into #rstats If you want to retain user defined missing values in your data (-98 = refused), don't forget to add the "user_na = TRUE" argument if you are using haven::read_sav(). Otherwise, user-defined missing values import as NA.

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 14/04/2026

Well that’s a first, patient with a translocation breaking two tumor suppressors in one event, TENT5C and BIRC3

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 12/04/2026

Gotta pull this one down, finally understand basket versus umbrella designs

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Reposted by Jonathan Keats, PhD 🇨🇦

Harmit Singh Malik @harmitmalik.bsky.social · 11/04/2026

I have been a PI for ~23 years now. Some of the things we do routinely in the lab now in molecular biology, genetics/genomics, I would never have believed possible when I started in science more than 30 years ago. But somehow fixing a broken microwave door latch mechanism is beyond me.

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Reposted by Jonathan Keats, PhD 🇨🇦

Kate Prior @doctorwibble.bsky.social · 08/03/2026

Happy International Women’s Day!

It’s a white font on a black background and it says
“To the woke who are labeled…
Aggressive: keep on being assertive
Bossy:keep on leading
Difficult: keep telling the truth
Too much: keep taking up space
Complicated: keep asking difficult questions”

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Reposted by Jonathan Keats, PhD 🇨🇦

Dan Immergluck @danimmergluck.bsky.social · 08/04/2026

Brutal.

A WHOLE CIVILIZATION
WILL DIE TONIGHT
My son needs lunch, and I have to put his backpack together, but a whole civilization will die tonight, so I'm wondering if they've closed their schools.
Like, a snow day, maybe, except instead of snow it's
"keep your children home so if you die, you die together" — instead of "well open back up once the plows have cleared" it's
"we don't know if we'll be here tomorrow, hold your babies tight."
It's just "talk" I'm told, which I've been told before.
"It's how the president makes his deals." But I've never heard anyone talk about other human beings this way, and I'm not certain I can look my son in the eyes if we all agree to stomach it one more time.
A civilization will die tonight, but as I zip up his backpack and kiss him off to school I think: if this is what we call leadership then I'm not entirely sure ours isn't already dead.
@michaelfdubois
Mukad A QuBoy
@michacifdubois

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Reposted by Jonathan Keats, PhD 🇨🇦

glastomichelle.bsky.social @glastomichelle.bsky.social · 08/04/2026

Crystal clear sunrise today. Photo taken this morning on Glastonbury Tor.

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Reposted by Jonathan Keats, PhD 🇨🇦

Posit @posit.co · 08/04/2026

We are thrilled to announce that Positron Server is now available for academic use via JupyterHub! This gives students a robust #RStats & #Python data science IDE without needing a local install or new infrastructure. Learn more: positron.posit.co/blog/posts/2...

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Reposted by Jonathan Keats, PhD 🇨🇦

Crystal Lewis @cghlewis.bsky.social · 03/04/2026

I recently shared a blog post written by Britt DeVries on how she used ChatGPT to create REDCap data dictionaries. I was so inspired by her post that I wrote my own on my experience using Claude to create a data dictionary draft. cghlewis.com/blog/claude_...

cghlewis.com

Creating data dictionary drafts using Claude | Crystal Lewis

This post walks through an example of the documentation and prompts you can provide to Claude Sonnet 4.6 to get a working draft of a data dictionary for a data collection form.

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 29/03/2026

“Brothers and sisters, this is our God: Jesus, King of Peace, who rejects war, whom no one can use to justify war,” Leo said. “He does not listen to the prayers of those who wage war, but rejects them, saying: ‘Even though you make many prayers, I will not listen: your hands are full of blood.’”

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 23/03/2026

LongcalID, This sounds promising, bringing variant calling of most types in a single process, now if we could just add copy number, but at least this brings together phased SNV/INDEL calling with SV calling and maybe some somatic mosaic detection. @lh3lh3.bsky.social www.biorxiv.org/content/10.6...

biorxiv.org

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 23/03/2026

General statistics question, does a wide body jet always load faster on the right or left aisle, going towards the tail of the plane? My flight tonight had a long line on the right side and no line on the left, but apparently a completely full flight

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 23/03/2026

After nearly 20 years of work we are bring advanced genetic testing to the clinic, with a deep whole genome sequencing test that returns results to physicians in under 3 days, seeing it change some treatment plans is easily the highlight of my career

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Reposted by Jonathan Keats, PhD 🇨🇦

richardndl.bsky.social @richardndl.bsky.social · 21/03/2026

Communication about Multiple Myeloma is extremely difficult. Terms that are either extremely complex or vaguely dumbed down. I decided to start from the beginning and read "Hematology for Beginners" by Richard J. Brooks. It is aimed at a high school audience. Very helpful. #Myeloma

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Reposted by Jonathan Keats, PhD 🇨🇦

Fulcrum Genomics @fulcrumgenomics.com · 20/03/2026

HGVS parsing sounds straightforward until you run it at scale across real clinical variants. We just released ferro-hgvs, a Rust-based parser/normalizer that processes millions of variants per second & handles many tricky edge cases other tools struggle with. 🔗 hgvs.acgt.bio Details in blog post👇

hgvs.acgt.bio

HGVS Normalizer - Powered by ferro-hgvs

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Reposted by Jonathan Keats, PhD 🇨🇦

Wolfram Höps @wolfram-hops.bsky.social · 06/03/2026

🔄 Inversions predispose to recurrent deletions and duplications in chromsome 15q13.3. 🔁 Using de-novo assemblies of 10 patient-parent trios, we investigated how recurrent copy-number variants (CNVs) in the 15q13.3 locus arise. www.biorxiv.org/content/10.6... A brief tour (1/17)

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 05/03/2026

My future rig, first R2 I’ve seen in the wild #Rivian @rivianofficial.bsky.social can’t wait for a real production version. I must want one paid to charge just to take a peak

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Reposted by Jonathan Keats, PhD 🇨🇦

James Ferguson @psy-fer.bsky.social · 01/03/2026

Introducing kuva: A scientific plotting library in rust, along with cli binary with the option to plot directly into the terminal. Feel free to drop me some feedback as an issue on the repo github.com/Psy-Fer/kuva crates.io/crates/kuva/...

github.com

GitHub - Psy-Fer/kuva: A scientific plotting library in Rust

A scientific plotting library in Rust. Contribute to Psy-Fer/kuva development by creating an account on GitHub.

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 22/02/2026

Argh, overtime, come on 🇨🇦 just need one past the goalie, US goalie is keeping them in the game

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 14/02/2026

@rahulbanerjeemd.bsky.social seeing in the airport, so have not read it, first question is if this is the rare hyper mutated myeloma cases. But nice to see people try checkpoint inhibitors again, lots of anecdotal reports of good responses

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Reposted by Jonathan Keats, PhD 🇨🇦

Davis Vaughan @davisvaughan.bsky.social · 04/02/2026

dplyr 1.2.0 is out now and we are SO excited! - `filter_out()` for dropping rows - `recode_values()`, `replace_values()`, and `replace_when()` that join `case_when()` as a complete family of recoding/replacing tools These are huge quality of life wins for #rstats! tidyverse.org/blog/2026/02...

tidyverse.org

dplyr 1.2.0

dplyr 1.2.0 fills in some important gaps in dplyr's API: we've added a new complement to `filter()` focused on dropping rows, and we've expanded the `case_when()` family with three new recoding and re...

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 04/02/2026

Good concept, but very dangerous to use before details are published. I’m very skeptical of myeloma MRD by flow on the blood samples and clinically dangerous to assume results are comparable to BM Euroflow NGF or adaptive BM NGS

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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 24/01/2026

Fantastic work from a world class group @ucalgary.bsky.social led by Nizar Bahlis and up and coming rock star Holly Lee who are leading the world in understanding how #myeloma patients become resistant to immunotherapies

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