0.12.0 — faster on both architectures, a faster --meth, and a large safety pass A broad optimization release that speeds up both Arm and x86 (unlike 0.11.0, which concentrated on Arm), plus a methy...

For those running the fgumi command line tools v0.7.0 makes sort faster, hardens CODEC consensus, and brings dedup metrics to Picard/dupblaster parity. Sort is up to 28% faster — and 2–3× faster th...

ALT: Ragnar Onurcem: Charismatic Leader

Rebuilding DivRef so CRISPR off-target searches can account for human variation

How Sassy enumerates every reasonable alignment without sacrificing runtime

0.8.0 — a verified drop-in for bwa-mem2, ~13% faster, and corrected methylation tags 1. --compat=bwa-mem2 — swap in bwa-mem3 and get the same BAM The big one. Run bwa-mem3 mem --compat=bwa-mem2 ......

Read-ahead / write-behind byte IO: threaded Reader/Writer that decouple a pipeline stage from the kernel pipe via a background thread and a byte ring buffer - tfenne/rawb-io

0.7.0 — methylation accuracy, a sharper --fast, and broad speedups This is primarily a methylation release. The bisulfite path was reworked to a chemistry-aware contract — TAPS support, a NEUTRAL -...

How Sassy enumerates every reasonable alignment without sacrificing runtime

Learn bioinformatics from your browser, no setup required. Everything runs in a sandbox, so you can experiment all you want.

Building translational strategies marries new methodologies with an unanswered clinical question, then works with the data and analyses needed to answer it When I think about what translational scienc...

Fulcrum-owned Rust HLA/KIR genotyper (strangler port of T1K) - fg-labs/unum

Added (reference) validate manifest schema/version at load, fail loud on an incompatible reference (#1003) (mosaic) parse predicted-wrapper and whole-entity-LHS =/ forms (#992) (protein) parse ins...

Nature Methods - EviAnn surpasses existing genome annotation methods by leveraging gene expression and protein sequence homology evidence to achieve higher accuracy and efficiency.

0.5.0 (2026-07-04) Features add opt-in --seed-order seed reordering (default off, byte-identical) (#186) (04749a1) add opt-in --smem-dedup (dedup identical SMEMs before chaining) (#187) (1384972) ...

Heng Li and Nils Homer revisit BWA-MEM with a faster mapper for short reads, accurate long reads, and bisulfite sequencing data.

salmon 2.2.1 The recommended 2.2.x release: it carries the full 2.2.0 feature set plus a security fix for a lz4_flex advisory pulled in by the new RAD compression. If you are on 2.2.0, upgrade. No ...

Blazingly fast, streaming duplicate detection for NGS data - fulcrumgenomics/dupblaster

ALT-aware mapping via post-extension liftover groups Draft for design feedback, opened against this fork's master. It adds optional ALT-contig awareness: given a .alt file, reads whose confiden...

Accelerated short-read alignment, derived from bwa-mem2

Rust and Python bindings for minibwa — Heng Li's lightweight bwa - fg-labs/minibwa-bindings

Fast SAM/BAM sorter. Contribute to fg-labs/mako development by creating an account on GitHub.

Fast, highly accurate, read-trimming for NGS data. - fulcrumgenomics/chelae

YouTube video by OMGenomics

Fast SAM/BAM sorter. Contribute to fg-labs/mako development by creating an account on GitHub.

Java JNI wrapper around libdeflate for faster DEFLATE/gzip/zip on the JVM - fulcrumgenomics/jlibdeflate

A New UMI Toolkit for Next-Gen Sequencing

Fast quality control tools for sequencing data, written in Rust.

GA4GH refget Sequences v2.0.0 and Sequence Collections v1.0.0 — server, client, and CLI tools in Rust - fulcrumgenomics/refget-rs

Tools for working with the outputs of kraken2. Contribute to fulcrumgenomics/k2tools development by creating an account on GitHub.

Fulcrum Genomics 10th Anniversary Series

Fulcrum Genomics 10th Anniversary Series