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Pat Madden

@patmadden.bsky.social
164 followers 397 following 4 posts

Postdoc in the Crotty Lab at LJI studying HIV vaccines and B cell immunology

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Reposted by Pat Madden
Apoorva Mandavilli @apoorvanyt.bsky.social · 07/10/2026
The future of four large research networks that test vaccines and treatments for HIV, TB and emerging infectious diseases is in limbo after weeks of delays from the Trump administration in launching the process to renew their funding. 🎁 🔗 www.nytimes.com/2026/10/07/h...
nytimes.com
Trump Administration Delays Threaten Funding for HIV Research (Gift Article)
The networks also develop treatments and preventions for other infectious diseases and were instrumental in testing the Covid vaccine.
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La Jolla Institute for Immunology (LJI) @lji.org · 22/09/2026
We’re thrilled to celebrate four LJI researchers named 2026 Scilit Top Cited Scholars: Alessandro Sette, Dr. Biol. Sci., Shane Crotty, Ph.D., Daniela Weiskopf, Ph.D., and Bjoern Peters, Ph.D.! #Immunology #SanDiego #ImmuneSystem #Health #Medicine
Collage with portraits of four scientists: Alex Sette, Shane Crotty, Daniela Weiskopf, and Bjoern Peters. Text reads: FOUR LJI scientists named 2026 Scilit Top Cited Scholars
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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 28/07/2026
Upwards of 200,00 people may have lost their jobs today; or will in the upcoming days. There is a palpable sense of fear among the Haitian community right now. They need your support.
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David Grimm @david-grimm.bsky.social · 14/07/2026
A lack of financial support from the NIH may have doomed a plan to convert the Oregon National Primate Research Center--one of the largest monkey facilities in the country--into a sanctuary where no research is done. My latest for @science.org
science.org
Plan to turn major monkey research facility into sanctuary may be dead
Lack of federal funds may have forced Oregon university to drop idea of converting national primate center into science-free refuge
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Atul Gawande @agawande.bsky.social · 13/07/2026
More signs of resurging HIV after USAID’s closure. African Neonatal Network reported at IMNCH (a global health conference): HIV+ pregnant women ↑50% & those not on antiretrovirals ↑>300%, year-on-year, across 22 hospitals in 5 nations. @vtoxfordnetwork.bsky.social
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Greg Folkers @gregfolkers.bsky.social · 10/07/2026
Lancet: Ending HIV: a reality check bit.ly/4vRGVTj
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Nick Kristof @nickkristof.bsky.social · 01/07/2026
Elon Musk says that no one died because of his demolition of USAID, and that "Kristof is lying through his teeth." So here I invite him to join me on a visit to Africa to see for himself: www.nytimes.com/2026/07/01/o...
nytimes.com
Opinion | U.S.A.I.D. Cuts Killed People. That’s the Truth.
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Pat Madden @patmadden.bsky.social · 01/07/2026
Our exciting new HIV vaccine paper was published in Nature today. Thanks to Shane for the amazing opportunity to lead this study!
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The Bulwark @thebulwark.com · 19/06/2026
How did people hear of the end of slavery? The testimonies from five men and women from four different states recount how they heard and responded to the news of their freedom.
lnk.thebulwark.com
Juneteenth: ‘The Day of Freedom Came’
First-person accounts of emancipation.
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La Jolla Institute for Immunology (LJI) @lji.org · 02/06/2026
New investigation by @settelab.bsky.social and @albagrifoni.bsky.social shows how T cells target conserved epitopes on #measles and Nipah viruses. Findings could guide development of vaccines against broad paramyxovirus family: www.lji.org/news-events/... #health #medicine #immunology
lji.org
T cells may be key to stopping measles virus—and its deadly relatives
LJI researchers discover that 'cross-reactive' T cells can recognize measles and the highly lethal Nipah virus
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La Jolla Institute for Immunology (LJI) @lji.org · 01/06/2026
New T cell research shows how we could develop #hantavirus vaccines and therapies: bit.ly/4fkseTs Key findings from @settelab.bsky.social, @albagrifoni.bsky.social and @iedb.bsky.social #health #medicine #VaccineResearch #Andeshantavirus
bit.ly
How our immune cells combat Andes hantavirus
LJI scientists lead pandemic preparedness as they develop strategies for stopping rodent-borne viruses
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Melody Schreiber @melodyschreiber.com · 24/05/2026
PEPFAR is enormously popular -- and now voters are seeing what happens when we abandon health systems around the world. My latest: www.theguardian.com/us-news/2026...
theguardian.com
US voters support HIV/Aids relief – will Trump’s cuts backfire in the midterms?
Global Pepfar program has long had Republican leadership and bipartisan support, but initiative is under fire
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Dr. Tom Frieden @drtomfrieden.bsky.social · 26/05/2026
In a matter of days, the U.S. State Dept. plans to fundamentally weaken PEPFAR—a 25-year bipartisan success—which would affect 8 million HIV patients and dismantle the same labs, teams of epidemiologists, and rapid-response systems we rely on to respond to diseases such as the Ebola outbreak in DRC.
statnews.com
8 former CDC directors: Reform PEPFAR, don’t dismantle it
A State Department plan scheduled to be implemented June 1 would strip the U.S. of decades of disease defense, write eight former CDC directors.
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Chris Murphy @chrismurphyct.bsky.social · 21/05/2026
Here's how the corruption works: Thursday: RJ Reynolds donates $5M to Trump Saturday: Trump invites RJR execs to Mar a Lago; execs ask to loosen regs on flavored vapes; Trump calls up RFK Jr. and tells him to change it Friday: FDA changes the policy
nytimes.com
Trump Administration Live Updates: President’s Ballroom and New Fund Face Test in Congress
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Philip Bump @pbump.com · 30/04/2026
In Dec 2021, Nicole Saphier — a Fox contributor now tapped as Trump's surgeon general nominee — argued that "it is time to move forward and allow this mild infection to circulate so we can continue to build that hybrid immunity." 250,000 Americans died of covid in 2022.
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La Jolla Institute for Immunology (LJI) @lji.org · 30/04/2026
There's a hidden army of immune cells in your nasal passages — and we can train them to fight the flu! 💪 Check out our new #FluMist study from LJI Professor & CSO Shane Crotty (@profshanecrotty.bsky.social): bit.ly/3QQiKoH #Health #Medicine #Biology #VaccineResearch #SanDiego
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Michael Hobbes @michaelhobbes.bsky.social · 30/04/2026
The indictment is absolute soup. Lab leakers have completely given up on proving their main contention and are now just flailing around looking for any rule violation or procedural misstep that makes it look like a cover-up happened. www.justice.gov/opa/pr/forme...
According to the indictment, Morens, Co-Conspirator 1, Co-Conspirator 2, and others conspired during the COVID-19 pandemic to defraud and commit several offenses against the United States after NIH terminated Co-Conspirator 1’s grant. NIH terminated the grant, Understanding the Risk of Bat Coronavirus Emergence (bat coronavirus grant), based on allegations that COVID-19 emerged from the Wuhan Institute of Virology (WIV) in Wuhan, China. NIAID awarded the grant to Company #1 and Co-Conspirator 1, who made a subaward to the WIV.

Following the termination, Morens and Co-Conspirator 2 pledged to help Co-Conspirator 1 restore the termination of the bat coronavirus grant and counter the narrative that COVID-19 leaked from a lab. In anticipation that their communications would be requested through a FOIA Request, Morens, Co-Conspirator 1, and Co-Conspirator 2 agreed in writing to intentionally hide from public view their communications by corresponding using Morens’s personal Gmail account, rather than his official NIH email account.
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Science Magazine @science.org · 29/04/2026
A clinical study shows how the intranasal FluMist vaccine can elicit potent antiflu immunity at mucosal sites, researchers tie persistent T cells in the liver to clinical cure of chronic hepatitis B, and more this week in #ScienceTranslationalMedicine. scim.ag/4t5ZqRH
This illustration demonstrates a healthy retina (left panel) with retinal ganglion cells (RGCs) highlighted in blue and other retinal cells colored green, orange, and pink.
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Prof. Shane Crotty @profshanecrotty.bsky.social · 14/04/2026
My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy! @lji.org @cp-immunity.bsky.social authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Oni Blackstock, MD MHS @oniblackstock.bsky.social · 10/04/2026
Today, April 10, is National Youth HIV & AIDS Awareness Day (#NYHAAD), a day to educate and urge policymakers and the public regarding the impact of HIV and AIDS on young people. Visit iamhivpossible.org to find an HIV testing or PrEP site. #IAmHIVPossible
Graphic reading “National Youth HIV & AIDS Awareness Day” with a red awareness ribbon integrated into the text, and “April 10” highlighted below. The design features bold white lettering over a black background with layered, curved shapes in red, purple, blue, and green.
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Melissa Barber @mbarber.bsky.social · 30/03/2026
Today, MSF is going public with something we've been fighting behind closed doors for months: Gilead will not sell us their new HIV drug, lenacapavir. The sticking point isn't even price, they just refuse to sell. Open letter linked + explainer 🧵1/ www.doctorswithoutborders.org/latest/gilea...
doctorswithoutborders.org
Gilead refuses to sell groundbreaking HIV prevention drug to MSF
Blocking humanitarian organizations from accessing a medical breakthrough puts vulnerable people across the world in danger.
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Immunity @cp-immunity.bsky.social · 26/03/2026
Online now: Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies
dlvr.it
Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies
Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al. investigate influenza-specific antibodies to obtain a deeper understanding of how inherited differences influence the response. Their results highlight population vulnerabilities that could be mitigated in the design of globally protective vaccines.
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MinnMax @minnmax.com · 23/01/2026
In solidarity with today's ICE OUT OF MINNESOTA blackout, MinnMax is donating $1 to the Immigrant Law Center of Minnesota for every share of this Bluesky post for the next hour.
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Mr. Dan Zak @mrdanzak.com · 15/01/2026
Stunning photos from Minneapolis, including this one by John Locher for the Associated Press. www.theatlantic.com/photography/...
A family member reacts after a federal immigration officer used a battering ram to break down a door before making an arrest on January 11, 2026, in Minneapolis.
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Gregg Gonsalves @gregggonsalves.bsky.social · 05/01/2026
Children will die with RFK Jr.'s new vaccine recommendations. We're NOT doing the "experts disagree" game. The US vaccine schedule was painstakingly constructed through a deep & thorough process by experts with unquestionable expertise. This is policy by fiat. It is pre-meditated murder. 1/
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Popular Science @popsci.com · 18/12/2025
The name "Popular Science" doesn't mean we shift our coverage depending on public opinion. It means we cover relevant subjects that are rigorously researched, reliable, and grounded in reality. And trans lives are grounded in reality. We see y'all. No matter what. www.popsci.com/science/tran...
popsci.com
First-of-a-kind study shows encouraging data for trans kids who socially transition
Ninety-four percent of participants in a new study stood firm in their trans identity after five years, and "detransitioning" is rare.
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Positively Aware @posaware.bsky.social · 11/12/2025
The real promise of lenacapavir for PrEP goes beyond the drug itself, by offering more choice, more flexibility and a better chance that everyone can find an HIV prevention option that fits their life, writes @johnmeadejr.bsky.social. www.positivelyaware.com/from-promise-to-programs
positivelyaware.com
From promise to programs—How to ensure PrEP science is translated into global impact
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Pam Herd @pamherd.bsky.social · 16/12/2025
“The president doesn’t know and never will,” she told me. “He doesn’t know the details of these smallish agencies.” -Susie Wiles on the destruction of USAID, which has led to 600,000 deaths, including ~400,000 children, in the last year alone. www.vanityfair.com/news/story/t...
vanityfair.com
Susie Wiles Talks About The First Year of Trump’s Second Term (Part 1 of 2)
In the first half of ‘Vanity Fair’’s interview with Susie Wiles, the chief of staff discusses Elon Musk’s DOGE disaster, the FBI’s “incredible job” investigating January 6, and how Trump once berated ...
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Adam Schwarz @adamjschwarz.bsky.social · 02/12/2025
RFK Jr: "Two weeks ago we ended, under your leadership, a twenty year war on women". Three out of five men in this shot have been accused of sexual misconduct, harassment or abusive behaviour towards women. A fourth signed into law a near-total abortion ban in his state as governor.
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IDSA @idsainfo.bsky.social · 01/12/2025
This #WorldAIDSDay, help us call on Congress to fully fund federal HIV programs: idsociety.quorum.us/campaign/148...
idsociety.quorum.us
We cannot go back: Act now to save HIV funding
Urge your members of Congress to fully fund federal HIV programs as they negotiate final funding levels for the FY 2026 LHHS spending bill.
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HIVMA @hivma.bsky.social · 01/12/2025
Fear and uncertainty hang over much of the HIV community this #WorldAIDSDay as we reflect on lives lost, progress made and current efforts to unravel our country’s HIV response. Action must follow our reflection this year. Our statement: bit.ly/4ot4mOi
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Apoorva Mandavilli @apoorvanyt.bsky.social · 26/11/2025
SCOOP: The Trump administration has instructed employees and grantees not to use U.S. funds to commemorate World AIDS Day — because the observance was started by the World Health Organization. www.nytimes.com/2025/11/26/h...
nytimes.com
Trump Administration Cancels U.S. Observance of World AIDS Day
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Gregg Gonsalves @gregggonsalves.bsky.social · 24/11/2025
As someone who has worked in HIV for 35+ years, I can tell you Carl is a consummate scientific leader. We’ve been lucky to have him at head of DAIDS. The only thing that wins here is the virus.
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Jeremy Berg @jeremymberg.bsky.social · 24/11/2025
Unfortunately, I can confirm that this is true. I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems. Huge unnecessary loss of leadership and expertise.
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Jeremy Berg @jeremymberg.bsky.social · 21/11/2025
Absolutely. Even if he weren't a damaged creep, his approach to scientific evidence is completely disqualifying. We know the answer; We just don't have the science yet There is no study that says that it is not true. Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
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Carl Quintanilla @carlquintanilla.bsky.social · 21/11/2025
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Ana Marie Cox @anamariecox.com · 14/11/2025
From this minister's op-ed: "People wanting to experience God are more likely to meet the Divine trying to shut down the Broadview, Illinois, ICE facility than we ever were in church...God does not live in our houses of worship, but...with those who are bearing the brunt of cruelty in this moment."
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Ester Marina-Zárate @estermz.bsky.social · 12/11/2025
Happy to share our latest work! This study would not have been possible without the amazing Crotty Lab team, our collaborators at the Scripps CHAVD HIV vaccine consortia, and crucial support from NIH funding. Grateful to be part of this effort!
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60 Minutes @60minutes.bsky.social · 10/11/2025
“We are doing a service for the United States because they’ve identified needs that need to be met,” says Harvard bioengineer Don Ingber, defending federal grants and contracts to universities for scientific and medical research. cbsn.ws/4hRoEiJ
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Gregg Gonsalves @gregggonsalves.bsky.social · 02/11/2025
Some charts for those who don't know the extent of the US public (and private) investment in research (particularly in biomedical research) compared to other countries and institutions. The destruction of the US' scientific institutions has global implications.
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Waggoner Lab @labwaggoner.bsky.social · 17/10/2025
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu www.science.org/doi/10.1126/...
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Asia Russell @asia-ilse.bsky.social · 14/10/2025
Me in Vox.com on the need for ambitious global roll out of the revolutionary HIV prevention injection lenacapavir--and how Vought's theft of PEPFAR funding & State's Jeremy Lewin's weak approach and ideological bent will sabotage the effort--unless we fight back: www.vox.com/future-perfe... >>
vox.com
The only thing standing between humanity and the end of HIV
Even Trump is fast-tracking this innovative new drug. What could go wrong?
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Asia Russell @asia-ilse.bsky.social · 14/10/2025
🚨BREAKING:🚨 AIDS activists arrested occupying Senator Collins' DC office, demanding she stop GIVING IN to Russ Vought's illegal & deadly withholding of global HIV funding. See: healthgap.org/press/aids-a... Simultaneously, bodybags delivered to her Portland office by Maine activists 👇
healthgap.org
AIDS Activists Arrested at Sen. Collins’ Office, Demanding She Reverse Chokehold on Appropriated PEPFAR Funds for Lifesaving HIV Prevention and Treatment
Press StatementFor Immediate Release: October 14 2025Contact: Asia Russell, Health GAP:  (267) 475 2645 | asia@healthgap.orgElizabeth Koke, Housing Works: (646) 342 9350 | e.koke@housingworks.orgMarie...
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Prof. Shane Crotty @profshanecrotty.bsky.social · 21/07/2025
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations www.biorxiv.org/content/10.1...
biorxiv.org
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
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50501: The People’s Movement ❌👑 @50501movement.bsky.social · 02/07/2025
These are the weak points. You know what to do. First thing tomorrow, use 5calls.org and raise hell.
Call these U.S. Representatives and tell them to vote NO on the “Big Beautiful Bill”:

AZ-06, Juan Ciscomani
CA-22, David Valadao
CA-40, Young Kim
CA-41, Ken Calvert
CO-08, Gabe Evans
FL-07, Cory Mills
FL-13, Anna Paulina Luna
FL-27, Maria Elvira Salazar
IA-01, Mariannette Miller-Meeks
IA-02, Ashley Hinson
IA-03, Zach Nunn
MI-07, Tom Barrett
MO-02, Ann Wagner
NJ-07, Tom Kean Jr.
NY-17, Mike Lawler
OH-07, Max Miller
OH-10, Mike Turner
OH-15, Mike Carey
PA-01, Brian Fitzpatrick
PA-07, Ryan Mackenzie
PA-08, Rob Bresnahan
PA-10, Scott Perry
TN-05, Andy Ogles
TX-15, Monica De La Cruz
VA-01, Rob Wittman
VA-02, Jen Kiggans
WI-01, Bryan Steil
WI-03, Derrick Van Orden
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Aaron Rupar @atrupar.com · 25/06/2025
MERKLEY: How do you feel about being responsible for hundreds of thousands of kids dying because of your sudden interruption in these key programs? VOUGHT: I reject the assertion MERKLEY: I find your response both ignorant & callous. Few Americans have had a more devastating & disastrous impact
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Aaron Rupar @atrupar.com · 25/06/2025
Chris Murphy: "Trump & the Republicans are trying to engineer the most massive transfer of wealth from the poor & middle class to the wealthy in history of the country...that's super unpopular. So how do you pass it? You can only pass it if you also destroy democracy & the means of accountability"
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