Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

Myelin-reactive B cells entering the central nervous system capture cognate antigen from the parenchyma. Without T cell help, they rapidly die; however, Epstein-Barr virus LMP1 enables them to bypass ...

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activati...

The JASMINE study met the primary endpoint and key secondary and exploratory endpoints, including those indicating the potential of nipocalimab for steroid sparing SLE is one of the most prevalent and...

Natural Sciences Podcast · Updated Semimonthly · A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

CD21 initiates extrafollicular differentiation of autoantibody-secreting cells in an SLE model driven by TLR7 signaling.

Plasma cells (PC) contribute to the pathogenesis of autoimmune diseases by secreting autoantibodies. Strategies to target pathogenic PCs are thus required. Here, the authors profile different PC subse...

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

snoRNA Snord3-mediated epigenetic activation of ESM1 is a potential therapeutic target in rheumatoid arthritis.

This Review discusses latest advances in the field of cutaneous lupus, including the improved understanding of disease pathogenesis and emerging targeted therapies.

ExTH17 cells drive IL-17–independent chronic SKG arthritis in mice through up-regulation of CD44 and S1PR4 and cross-talk with FLS.

The dynamics of antigen-specific Tfh responses during extended germinal center reactions are not well characterized. Marina-Zárate et al. show that vaccine-specific Tfh cells in the lymph node undergo...

Fc receptor blockade by nipocalimab 15 mg/kg significantly improved clinical disease activity versus placebo and was safe and well tolerated in participants with moderate-to-severe, active Sjögren's d...

Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by dysfunction of exocrine glands, particularly the salivary and lacrimal glan…

Biallelic loss-of-function mutations in PLD4, as identified in five patients with SLE, lead to Toll-like receptor-driven hyperactivation of type I interferon, immune cell expansion and autoimmunity.

In a phase III placebo-controlled trial, the addition of telitacicept to standard therapy led to increased clinical response rates for people with systemic lupus erythematosus.

Nobel laureate makes regulatory T cells that last longer in the body, boosting clinical hopes

Single-cell transcriptomic analysis of blood CD4+ T cells from children with systemic lupus erythematosus (SLE) reveals an unexpected diversity of helper and regulatory cells that could underlie disea...

TIGIT, a coinhibitory receptor that suppresses excessive immune responses, also promotes tissue regeneration by functioning as a co-stimulatory receptor in regulatory T cells via the TIGIT–TCR–BLIMP1–...

Caielli and colleagues performed single-cell RNA sequencing on blood CD4⁺ T cells from pediatric patients with systemic lupus erythematosus and healthy donors, identifying naive, memory, Treg, prolife...

Rapidly progressive glomerulonephritis refers to a group of severe autoimmune kidney diseases. Using high-resolution spatial transcriptomics, we identified a common pathway of disease progression and ...

The objective of this study was to update the 2019 European Alliance of Associations for Rheumatology (EULAR)/ European Renal Association/European Dia…

Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with systemic lupus erythematosus, but the next stage of development must address key pi...

Regulatory T cells, which help to dampen inflammation, are being used in clinical trials against ailments such as rheumatoid arthritis.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.