Reposted by Nicholas TolleyAhmad Beyh @ahmadbeyh.bsky.social · 24/08/2026We trained 3 RNN classes on a working memory task. (1) Vanilla RNNs were only task-optimized. (2) Masked RNNs had brain-like input/output constraints. (3) bioRNNs were further constrained such that their connections were shaped by the brain’s Euclidean geometry. (2/8) 163
Reposted by Nicholas TolleyThomas Serre @thomasserre.bsky.social · 13/08/2026We're recruiting postdoc fellows in computational neuroscience for Brown's NIH T32 Training Program — brain & cognitive modeling from biophysics to AI, with connections to mental health & psychiatry. US citizens/PRs. Review begins Sept 1. @carneyinstitute @browncopsy apply.interfolio.com/190111 01412
Reposted by Nicholas TolleyMehdi Senoussi @cogsenoussi.bsky.social · 31/07/2026📢 PhD opening in comp. cog. neuro. in Toulouse: thalamo-frontal model of cognitive control. Modelling/EEG experience is welcome but not required. Application deadline: 8 Sept. 2026 Details: sdrive.cnrs.fr/s/eDrkeXfjdW... #CognitiveScience #Neuroscience #EEG #neuroskyence #compneurosky 02527
Reposted by Nicholas TolleybioRxiv Neuroscience @biorxiv-neursci.bsky.social · 16/06/2026Spectral decompositions of neural voltage recordings are susceptible to model misspecifications that cause meaningful estimation error www.biorxiv.org/content/10.64898/20… 033
Reposted by Nicholas TolleyBrad Postle @bradpostle.bsky.social · 12/06/2026Postdoc position available at postlab.psych.wisc.edu. Pls send cv to postle@wisc.edupostlab.psych.wisc.eduPO-STL-ABOur interests in human memory and cognition encompass the cognitive and neural basis of working memory, attention, control, and consciousness.News Madison Symposium on Memory & Control. On 30 May 202... 15571
Reposted by Nicholas TolleybioRxiv Neuroscience @biorxiv-neursci.bsky.social · 09/06/2026HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neuro-cognitive Modeling www.biorxiv.org/content/10.64898/20… 0178
Reposted by Nicholas TolleyProf Rick Adams @drrickadams.bsky.social · 18/05/2026📢PhD job alert! A exciting PhD project that involves using MEG and biophysical modelling to try to predict effects of a glutamatergic treatment for psychosis... plus you can develop your own side project. Join our great team! www.ucl.ac.uk/work-at-ucl/...ucl.ac.ukUCL – University College LondonUCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021). 12728
Reposted by Nicholas TolleyDurstewitzLab @durstewitzlab.bsky.social · 10/05/2026In a #ICML2026 position paper we argue a dynamical systems perspective is needed to drive time series models forward: arxiv.org/abs/2602.16864 For TS, we need to move away from transformers that do not respect a system’s dynamical structure, esp. if out-of-domain generalization & insight is sought. 05213
Reposted by Nicholas TolleyAperture Neuro @apertureohbm.bsky.social · 08/05/2026Donoghue et al. introduce the Human Single-Neuron Pipeline, an open source processing pipeline for collecting and analyzing human single-neuron data: doi.org/10.52294/001... @ohbmossig.bsky.social @ohbmofficial.bsky.social #OpenDatasets #SpecialIssues 085
Nicholas Tolley @ntolley.bsky.social · 05/05/2026Super glad to have our team's work on clinical applications of neural simulations highlighted in this article! Trying to bring academic work to the real-world has been a great experience and I'm quite excited to continue these efforts with @dvwz.bsky.social and @jonescompneurolab.bsky.social 0102
Reposted by Nicholas TolleybioRxiv Neuroscience @biorxiv-neursci.bsky.social · 01/05/2026Layer-specific wide-field calcium imaging of neocortical activity www.biorxiv.org/content/10.64898/20… 031
Reposted by Nicholas TolleyBiological Psychiatry @biologicalpsych.bsky.social · 01/05/2026In people at high risk for psychosis, reduced excitability of pyramidal cells predicts who will later convert to develop psychosis, suggesting this may be a root cause of schizophrenia rather than a consequence of the illness.biologicalpsychiatryjournal.comBiophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndromeReduced mismatch negativity (MMN) and P300 event-related potential (ERP) components are widely replicated in schizophrenia and are also observed in individuals at clinical high risk for psychosis… 031
Reposted by Nicholas TolleyImaging Neuroscience @imagingneurosci.bsky.social · 01/05/2026New paper in Imaging Neuroscience by Lindsey Power, Sylvain Baillet, et al: A neuroscientist’s guide to neural burst detection doi.org/10.1162/IMAG... 0269
Reposted by Nicholas TolleyDebbie Yee @debyee.bsky.social · 29/04/2026Headed to #SOBP2026? Come visit our posters on stress and mental effort! F325: Investigating the Role of Serotonin in Stressor Controllability and Mental Effort Allocation (me!) S297: Learning and Generalization of Stressor Controllability for Mental Effort allocation (Tony El Nemer) 075
Nicholas Tolley @ntolley.bsky.social · 27/04/2026Really excited for this conference! We’ve all been digging deep into different ways to use EEG to better understand and treat psychiatric diseases If you’re at SOBP definitely stop by our posters if you want to chat biophysical mechanisms, biomarkers, and deep learning approaches to EEG analysis 021
Reposted by Nicholas TolleyJan R. Wessel @janw.bsky.social · 24/04/2026New work, now out in PLoS Biology. Using intracranial recordings & EEG, we find that the human STN rapidly engages / releases motor inhibition depending on task context, does so in tight accord w/ frontal cortex, and shows little to no lateralization while doing so. journals.plos.org/plosbiology/...journals.plos.orgA cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental contextHow does the human brain stop movements under realistic conditions? Using intracranial recordings and multi-variate EEG decoding, this study shows that a fronto-basal ganglia circuit featuring the sub... 03419
Reposted by Nicholas TolleyAnn Huang @annhuang42.bsky.social · 23/04/2026[ #ICLR2026 ] How do we know if two systems are performing the same computation when they are constantly driven by different external inputs? 🧠🤖 I’ll be presenting our novel method InputDSA tomorrow April 23 (2:15pm-4:45pm EDT in Pavilion 3 P3-#1614)📍 Come swing by our poster! I’d love to chat! 0248
Reposted by Nicholas TolleybioRxiv Neuroscience @biorxiv-neursci.bsky.social · 13/04/2026Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver www.biorxiv.org/content/10.64898/20… 022
Nicholas Tolley @ntolley.bsky.social · 17/04/2026Happy to share a new preprint from the @hnnsolver.bsky.social team!🧠💻🎉 "Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver" 📝 www.biorxiv.org/content/10.6... 12311
Reposted by Nicholas TolleyAthena Akrami @athenaakrami.bsky.social · 13/04/2026New preprint! 🧠 How do RNNs learn abstract rules from sequences, independent of specific stimuli? By Vezha Boboeva, with Alberto Pezzotta & George Dimitriadis "From sequences to schemas: low-rank recurrent dynamics underlie abstract relational representations" www.biorxiv.org/content/10.6... 111136
Reposted by Nicholas TolleyCMC Unit @cmc-unit.bsky.social · 07/04/2026Thrilled to see the second paper of the lab out 🤩 Check it out if you need a method to infer causality from neural data, even when the signal is short! Paper: joss.theoj.org/papers/10.21... Code: github.com/CMC-lab/Tran...joss.theoj.orgTranCIT: Transient Causal Interaction ToolboxNouri et al., (2025). TranCIT: Transient Causal Interaction Toolbox. Journal of Open Source Software, 10(116), 9302, https://doi.org/10.21105/joss.09302 0126
Reposted by Nicholas TolleyRudebeck Lab @rudebecklab.bsky.social · 04/04/2026Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...nature.comDataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey - Scientific DataScientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey 210534
Reposted by Nicholas TolleyJames McAllister @jajmca.bsky.social · 02/04/2026Really excited to share a new preprint! 𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻𝘀 𝘀𝘁𝗮𝘆 𝗿𝗼𝗯𝘂𝘀𝘁 & 𝗲𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝘄𝗵𝗶𝗹𝗲 𝗯𝗲𝗶𝗻𝗴 𝗶𝗻𝗰𝗿𝗲𝗱𝗶𝗯𝗹𝘆 𝘀𝗽𝗮𝗿𝘀𝗲? We explore how! www.biorxiv.org/content/10.6... We built Connectome-based Neural Networks (CoNNs) using Drosophila wiring (larva&adult) & compared with random networks with same sparsity. 15213
Reposted by Nicholas TolleyKonrad Kording @kordinglab.bsky.social · 31/03/2026Preprint out arguing that we should build the techology to translate (compile) molecularly annotated connectomes into dynamics. I think this is incredibly important. arxiv.org/abs/2603.25713 45016
Reposted by Nicholas TolleyTodd Morrill @toddmorrill.bsky.social · 17/03/2026This work started when Christian Pehle, @tonyzador.bsky.social, and I found that training sequentially (consuming/producing one spike at a time) in JAX was prohibitively slow. You certainly can consume multiple spikes in parallel—TLDR; just use an associative scan—but... 2/N 142
Reposted by Nicholas TolleyJohn Tuthill @tuthill.bsky.social · 24/03/2026🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6... 10412151
Reposted by Nicholas TolleyNastya Krouglova @anastasiakrouglova.bsky.social · 22/03/2026Our paper “Multifidelity Simulation-based Inference for Computationally Expensive Simulators” has been accepted at ICLR 2026! 🥳 We hope this can be a practical solution for anyone analysing and doing inference on computationally expensive simulators. Paper: openreview.net/pdf?id=bj0dc... 15311
Reposted by Nicholas TolleyJoel I Berger @joelberger.bsky.social · 21/03/2026We have a new preprint examining single neuron responses in humans undergoing TMS (www.biorxiv.org/content/10.6...). The excellent Charlie Dickey led the way, and I had the privilege to co-supervise this work with @coreykeller.bsky.social and @aaronboes.bsky.social 🧵 (1/7) 🧠🟦 🧠💻 2278
Reposted by Nicholas TolleybioRxiv Neuroscience @biorxiv-neursci.bsky.social · 21/03/2026A Spatially Structured Spiking Network Model of Beta Traveling Waves and Their Attenuation in Motor Cortex www.biorxiv.org/content/10.64898/20… 042
Reposted by Nicholas TolleyAndrew Lampinen @lampinen.bsky.social · 17/03/2026Pleased to share that our paper "Representation Biases: Variance is Not Always a Good Proxy for Importance" is now out as Theory/New Concepts paper in eNeuro! www.eneuro.org/content/13/3... 1/eneuro.orgRepresentation Biases: Variance Is Not Always a Good Proxy for ImportanceA central approach in neuroscience is to analyze neural representations as a means to understand a system's function, through the use of methods like principal component analysis, regression, and repr... 17229
Nicholas Tolley @ntolley.bsky.social · 18/03/2026Happy to share a new preprint from my PhD thesis! “A novel framework for expanding RNNs with biophysical detail to solve cognitive tasks” 🧠💻 📝 www.biorxiv.org/content/10.6... @jonescompneurolab.bsky.social 15618
Reposted by Nicholas TolleybioRxiv Neuroscience @biorxiv-neursci.bsky.social · 17/03/2026Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function www.biorxiv.org/content/10.64898/20… 061
Reposted by Nicholas TolleyDecision, Action, and Neural Computation (DANC) lab @danclab.bsky.social · 09/03/2026We've been saying for a while now that beta bursts might be functionally heterogeneous. Check out @quentinmoreau.bsky.social's paper where we show that different types of bursts have different relationships to behavior in a sensorimotor adaptation task 👇👇👇 1148
Reposted by Nicholas TolleyDANDI Archive @dandiarchive.org · 27/02/2026Mission: record hippocampal place cells in zero gravity Crew: 3 rats with electrode arrays Vehicle: Space Shuttle Columbia Status: data now publicly available on DANDI, 28 years later The ratstronauts' mission is finally complete. 🐀🚀 h/t NASA about.dandiarchive.org/blog/2026/02... 26123
Reposted by Nicholas TolleyNatalie Schaworonkow @nschawor.bsky.social · 20/02/2026underappreciated concept 🙂 for more dipoles: neighboring dipoles have different orientations & can have different stimulus preferences. so even though topographies look similar, subtle differences remain. maybe that's why it is possible to decode information from relatively few sensors? 1208
Reposted by Nicholas TolleyAlina Studenova @studenova.bsky.social · 20/02/2026The angle of the dipole obviously matters. If active dipoles in two conditions are slightly misaligned, a difference can be observed. However, this difference is not driven by differences in amplitudes, but only by differences in orientations. Here, I simulated such a scenario. #brainmovies 0185
Reposted by Nicholas TolleyTian Wang @tianw0318.bsky.social · 05/02/2026Excited to share our new findings: distinct neural dynamics in prefrontal and premotor cortex during flexible decision making, preprinted on biorxiv. www.biorxiv.org/content/10.6...biorxiv.org 1217
Reposted by Nicholas TolleyWilliam Ngiam | 严祥全 @williamngiam.github.io · 01/12/2025Do you have an open working memory dataset and want it to be findable and reused? You can now add it to the Open WM Data Hub: williamngiam.github.io/OpenWMData! The collection of datasets tagged with useful metadata is steadily growing thanks to a small team of volunteers!williamngiam.github.ioOpenWMDataA collection of publicly available working memory datasets 36540
Reposted by Nicholas TolleyEugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 01/12/2025Unit tests in research code feel like something that's slowing you down until they wind up saving you six months of suffering 4749
Reposted by Nicholas TolleyGaute Einevoll @gauteeinevoll.bsky.social · 24/11/2025PhD position in computational neuroscience/brain physics to work with us on biophysical modeling of electric and magnetic brain signals at University of Oslo as part of the Marie Curie EU project @neuronanotechdn.bsky.social. Application deadline: December 9th. www.jobbnorge.no/en/available...jobbnorge.noPhD Research Fellow in computational neuroscience/brain physics (290338) | University of OsloJob title: PhD Research Fellow in computational neuroscience/brain physics (290338), Employer: University of Oslo, Deadline: Tuesday, December 9, 2025 0107
Reposted by Nicholas TolleyAnn Huang @annhuang42.bsky.social · 24/11/2025📍Excited to share that our paper was selected as a Spotlight at #NeurIPS2025! arxiv.org/pdf/2410.03972 It started from a question I kept running into: When do RNNs trained on the same task converge/diverge in their solutions? 🧵⬇️ 510927
Reposted by Nicholas TolleyJones Comp Neuro Lab @jonescompneurolab.bsky.social · 14/11/2025The Jones comp neuro lab is at #SfN25! Come check out our talks and posters to learn about our latest & greatest Science with HNN! All poster presentation times & locations can be found at jonescompneurolab.github.io/textbook/res...jonescompneurolab.github.ioHNN Textbook 184
Reposted by Nicholas Tolleyhardmaru @hardmaru.bsky.social · 05/11/2025Excited to release our new work: Petri Dish Neural Cellular Automata! pub.sakana.ai/pdnca We investigate how multi-agent NCAs can develop into artificial life 🦠 exhibiting complex, emergent behaviors like cyclic dynamics, territorial defense, and spontaneous cooperation. 13310
Reposted by Nicholas TolleySimone Papa @simonepapa.bsky.social · 01/11/2025No tricks, just brains in 3D 🧠🧟♂️ This cleared human brain slice (~10×7×0.3 cm) was imaged at 0.17 µm/pixel on the 3Di HOTLS lightsheet microscope. Sharp, transparent, undead-level perfection (Alpenglow Biosciences). #3Dtissueimaging #LightSheet #Halloween 051
Reposted by Nicholas TolleyAlina Studenova @studenova.bsky.social · 30/10/2025Today at #PracticalMEEG2025 Nick @willenjoy.bsky.social and I will be conducting a tutorial on how to simulate EEG/MEG data with our toolbox meegsim. If you happen to be around, come to our virtual booth; we will tell scary stories.👻 031
Reposted by Nicholas TolleyDurstewitzLab @durstewitzlab.bsky.social · 28/10/2025Revised version of our #NeurIPS2025 paper with full code base in Julia & Python now online, see arxiv.org/abs/2505.13192arxiv.orgTrue Zero-Shot Inference of Dynamical Systems Preserving Long-Term StatisticsComplex, temporally evolving phenomena, from climate to brain activity, are governed by dynamical systems (DS). DS reconstruction (DSR) seeks to infer generative surrogate models of these from observe... 0267
Reposted by Nicholas Tolleybrain rhythms lab @haegenslab.bsky.social · 23/10/2025Check out our latest work led by @joeyzhou.bsky.social on alpha oscillatory networks in PLOS Biology! ➡️ journals.plos.org/plosbiology/... Do ongoing alpha activity fluctuations influence perceptual sensitivity or criterion?journals.plos.orgDistinct alpha networks modulate different aspects of perceptual decision-makingFluctuations in alpha-band neural oscillations influence whether we perceive faint stimuli, but how these oscillations relate to different perceptual processes is not clear. This study shows that alph... 13015
Reposted by Nicholas TolleyDecision, Action, and Neural Computation (DANC) lab @danclab.bsky.social · 18/09/2025🚨Postdoc job offer🚨 Are you interested in beta bursts? Want to help drive methods for laminar inference with MEG? Now hiring a postdoc: run head-cast MEG experiments, help build our laMEG toolbox, and collaborate across Lyon–Marseille–Strasbourg. emploi.cnrs.fr/Offres/CDD/U... Please repost! 🧠📈emploi.cnrs.fr Portail Emploi CNRS - Offre d'emploi - Post-doctorate - Beta bursts & laminar MEG (M/F) 12111
Reposted by Nicholas TolleyPessoaBrain @pessoabrain.bsky.social · 21/10/2025Is the the neuroimaging community (broadly conceived) submitting to 𝗡𝗲𝘂𝗿𝗼𝗶𝗺𝗮𝗴𝗲 again????? Not to be publication police but the shift had seemed major 1-2 years ago. Looking at the editorial board it seems to have serious scientists once more. Curious about thoughts of the community. 7249