iiinova — where your digital self keeps evolving

Human Neocortical Neurosolver @hnnsolver.bsky.social · 26/05/2026

🎉 𝗛𝗡𝗡 𝘃𝟬.𝟲.𝟭 𝗶𝘀 𝗵𝗲𝗿𝗲! 🎉 The new v0.6.1 version has many upgrades, including running optimization inside the GUI, a major visual refresh of the GUI, support for new optimization solvers (CMA-ES) and objective functions, easier installation, accessibility improvements, and others.

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 04/05/2026

Want to support HNN in a meaningful way? One of the most helpful things you can do is to fill out our brief, anonymous demographics survey! It helps us better understand our users and supports our grant reporting. forms.gle/qWn9DZ3QD3Ao...

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HNN Voluntary Demographic Information

Thank you for your interest in supporting HNN! Any demographic information we collect is anonymized and aggregated for reporting on the grants that fund the continued development of HNN. The informati...

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 27/04/2026

We will be at the SOBP conference this week! Come see our exciting lineup of posters on psychiatric translational applications of HNN and similar mechanistic models. Presented by @ntolley.bsky.social, @darcywaller.bsky.social , Stephanie R. Jones, David Zhou, and Pran Chanthrakumar.

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Reposted by Human Neocortical Neurosolver

Nicholas Tolley @ntolley.bsky.social · 17/04/2026

Happy to share a new preprint from the @hnnsolver.bsky.social team!🧠💻🎉 "Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver" 📝 www.biorxiv.org/content/10.6...

Biophysical modeling to develop and test mechanistic hypotheses underlying pharmacological EEG biomarkers.

Top: Modeling EEG biomarkers begins with picking a specific brain signal that is reliably different between patient populations. An example of a hypothetical EEG biomarker is an auditory event related potential (ERP) that is suppressed in post-treatment (red) relative to pre-treatment (blue). Middle: Biophysical modeling allows for testing mechanistic hypotheses that explain how EEG biomarkers emerge and change with drugs. Hypotheses about which drug mechanisms lead to distinct brain activity patterns must be constructed, and corresponding model parameters identified. Bottom: The default HNN model is used as a starting point to test hypotheses by either manually altering the values of the chosen model parameters, or using automated optimization and inference algorithms. Differences in parameter values pre-to post-treatment correspond to model-based predictions.

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Nicholas Tolley @ntolley.bsky.social · 18/03/2026

Happy to share a new preprint from my PhD thesis! “A novel framework for expanding RNNs with biophysical detail to solve cognitive tasks” 🧠💻 📝 www.biorxiv.org/content/10.6... @jonescompneurolab.bsky.social

Multipanel figure illustrating the key components of the paper: 1) biophysical reservoir computing where a network of biophysically detailed excitatory and inhibitory neurons are randomly connected, receive a brief input, and produce a sustained spiking pattern in response, 2) an illustration of the task the biophysical reservoir computer is trained on: a simplified working memory task where the network must produce distinct fixed point attractors in response to different inputs.

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 28/02/2026

🌟 New funding opportunity to collaborate with us! 🌟 Do you have a question about the neural origin of your human EEG or MEG data? We have a tool that can help, and there is a new NIH grant mechanism to support collaboration with our team. Learn more and get in touch: forms.gle/tGfXE7ooszWS...

forms.gle

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 07/01/2026

We are still accepting responses to this survey!

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 14/11/2025

📣 Help us improve HNN features and educational resources for you! 📣 If you have heard about HNN, interacted with the software, or used it for a research project, we'd love to hear from you in this <5 min survey! forms.gle/LB29PXMbEQak...

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HNN Dissemination Feedback

This short survey aims to gather information on current community usage of the Human Neocortical Neurosolver (HNN) software. Please fill out this survey if you have heard of HNN, attended a workshop...

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Reposted by Human Neocortical Neurosolver

Jones Comp Neuro Lab @jonescompneurolab.bsky.social · 14/11/2025

The Jones comp neuro lab is at #SfN25! Come check out our talks and posters to learn about our latest & greatest Science with HNN! All poster presentation times & locations can be found at jonescompneurolab.github.io/textbook/res...

jonescompneurolab.github.io

HNN Textbook

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 10/11/2025

Join us on Nov 13th at the Neuroscience Gateway (NSG) online workshop! We will do a 30-minute introduction & demo of HNN features on NSG. More details and registration: www.nsgportal.org/NSG_SFN2025_...

nsgportal.org

Organizers: Amit Majumdar, Subhashini Sivagnanam San Diego Supercomputer Center, University of California San Diego

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 09/09/2025

SFN is around the corner again! If you are presenting on any HNN related projects at SFN, please share your presentation info with the community! #SfN25 #neurosky forms.gle/Q8TDZgELXJyj...

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SFN Presentations using HNN

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 10/03/2025

Want a high-level overview of how HNN works? Check out this short comic by our lab manager Joyce (@kermieeart.bsky.social)! tinyurl.com/27xrksez #compneuro #sciart #comics

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 04/03/2025

We invite you to join us at our 2025 Spring Online Human Neocortical Neurosolver (HNN) Workshop! This workshop will be on Wednesday, April 9th from 9 AM - 3 PM (ET). Find out more and sign up 👉 tinyurl.com/hnn-workshop.... Seats are limited! #compneuro

tinyurl.com

HNN Pre-Workshop Information

Workshop Overview The Human Neocortical Neurosolver (HNN) is a user-friendly software tool for interpreting the cell and circuit level origin of human MEG and EEG signals. In this virtual event, we ...

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Human Neocortical Neurosolver @hnnsolver.bsky.social · 14/01/2025

The Human Neocortical Neurosolver is on Bluesky! HNN is a user-friendly computational tool to develop & test hypotheses about the neural circuits underlying EEG/MEG signals. Our aim is to make comp neuro accessible to a broad community. Follow for HNN science, workshops & development! 🧠 👩‍🔬 #compneuro

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