Reposted by Neel ShahDirk Trauner @dirktrauner.bsky.social · 14/09/2026The Department of Chemistry at the University of Pennsylvania invites applications for a tenure-track position at the rank of Assistant Professor in the broadly defined area of organic chemistry. I have the honor of chairing the search committee. apply.interfolio.com/192648 12914
Reposted by Neel ShahAndres Bendesky @bendeskylab.com · 11/09/2026We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 082105
Reposted by Neel ShahMike Giuliano @drmikeg83.bsky.social · 28/08/2026Come join us and our great students in Charleston! The CofC Dept. of Chemistry and Biochemistry is hiring a tenure-track assistant prof in organic chemistry. We STRONGLY encourage organic chemists across the discipline to apply! I'm happy to answer any questions #chemsky jobs.cofc.edu/postings/17937jobs.cofc.eduAssistant Professor of Chemistry and Biochemistry (organic)Tenure-Track Assistant Professor in Organic Chemistry. The Department of Chemistry and Biochemistry at the College of Charleston invites applications for a tenure-track faculty position beginning in F... 003
Reposted by Neel ShahMary Munson @marymunson4.bsky.social · 26/08/2026Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).umassmed.eduMunson Lab | Home | BMB | UMass Chan Medical SchoolThe Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me... 12744
Neel Shah @nshahlab.bsky.social · 25/08/2026Excited to share our lab's latest paper led by recent graduate Minhee Lee, PhD., out in its final form at ACS Chemical Biology! Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases pubs.acs.org/acbcct/artic...pubs.acs.orgSubstrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine KinasesAbstractProtein tyrosine kinases are important regulators of cell signaling, and aberrant kinase activity contributes to many human diseases, including can 040
Reposted by Neel ShahGeorge Burslem @gburslem.bsky.social · 24/08/2026It's been a great couple of weeks for publications from the lab! First up we have a generalizable induced proximity system for gain of function PTM editing exemplified by acetylation and led by @briehp.bsky.social pubs.acs.org/acbcct/artic...pubs.acs.orgGeneral Strategy for Controlling Functional Lysine Acetylation via Induced ProximityAbstractAssigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events 2142
Reposted by Neel ShahRuben Gonzalez @rubenlgonzalez.bsky.social · 23/08/2026The NSF is on track to award 30% fewer new research grants this year—the lowest number in four decades. Basic science is the foundation of future medicines, technologies, and prosperity. We must fund it. www.nature.com/articles/d41...nature.comExclusive: NSF set to issue lowest number of new grants in four decadesThe US science-funding agency is withholding $1 billion of its budget so that the money can go to a special White House project. 032
Reposted by Neel ShahRoland Dunbrack 🏳️🌈 @rolanddunbrack.bsky.social · 09/08/2026Our paper on the active form of human protein kinases is out in Biochemical Journal from @biochemsoc.bsky.social . Great experience with the journal, unlike another journal that begins with "Nat" and ends with "omms." doi.org/10.1042/BCJ2... Made the cover in August (paper came out in July)... 3387
Reposted by Neel ShahMike Giuliano @drmikeg83.bsky.social · 03/08/2026Hey Chemists, we’re hiring, come join us! See the original post below, happy to answer questions. Charleston is a beautiful place to live, and we have great facilities, students, and colleagues! #chemsky @chemjobber.bsky.social 054
Reposted by Neel ShahFantauzzo Lab @fantauzzolab.bsky.social · 09/07/2026This piece really resonated with me - so often I've wished I could go back and assure my younger self that things will (mostly) work out: www.science.org/content/arti...science.orgTo my younger self, the overwhelmed new professor: You will make itHow this scientist navigated the tough decisions and personal strain of starting a lab 071
Neel Shah @nshahlab.bsky.social · 09/07/2026Congrats to Dr. Andrew Johns, the 7th PhD from our lab! He gave a great talk describing his project on using photo-crosslinking to identify tyrosine phosphatase substrates. His work dropped on bioRxiv yesterday: bsky.app/profile/nsha... 071
Neel Shah @nshahlab.bsky.social · 07/07/2026Excited to share this new preprint, led by graduate student Andrew Johns! We used amber suppression to install photocrosslinkers in PTP1B to enable identification of new substrates. Our method detects localization- and stimulation-dependent changes in substrate scope. www.biorxiv.org/content/10.6...biorxiv.orgIn situ identification of substrates of the protein tyrosine phosphatase PTP1B using site-specific photo-crosslinkingProtein tyrosine phosphorylation is critical for cellular function, and aberrant phosphorylation is tied to a wide range of human diseases. Identifying the substrates of protein tyrosine phosphatases,... 0102
Neel Shah @nshahlab.bsky.social · 06/07/2026Wow, this looks awesome and will be a great resource to anyone studying protein-protein interactions, SLiMs, and cell signaling! Excited to dig into this. Congrats to everyone involved! 061
Reposted by Neel ShahCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 23/06/2026“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...inpreparation.substack.comOpinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is DiscriminationBy Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University 99025
Reposted by Neel ShahKarolin Luger @nucleosomepolice.bsky.social · 20/06/2026Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...nytimes.comOpinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack 110977
Neel Shah @nshahlab.bsky.social · 13/06/2026Congrats, Weeks lab! Very enabling platform and a cool study! 131
Neel Shah @nshahlab.bsky.social · 04/06/2026Happy to introduce PhD #6, aka Dr. Minhee Lee! He gave a fantastic talk today and did a great job defending his dissertation! 0120
Reposted by Neel ShahCaroline Lynn Kamerlin ☀️ @lynnkamerlin.bsky.social · 01/06/2026Are you interested in understanding protein dynamics and allostery in biomedically relevant "loopy" enzymes? We are looking for postdocs to join our group at GT for both applied and method development work. If you are interested, please email me your CV, cover letter, and details of 2-3 referees. 1118
Reposted by Neel ShahFASEB @faseborg.bsky.social · 30/05/2026⌛ Don’t miss the June 1 registration deadline for #ProteinPhosSRC! This conference brings together scientists from around the world to share new discoveries in protein phosphorylation, disease mechanisms, and therapeutic development. Register now! buff.ly/YxSgh5Y 021
Reposted by Neel ShahChrystal Starbird @drstarbird.bsky.social · 29/05/2026We are hiring! This is a joint Lab Assistant position with @phosphotig.bsky.social ‘s lab. If you are organized and creative, enjoy learning new things, and if working with two great teams of scientists sounds appealing, please apply! unc.peopleadmin.com/postings/319...unc.peopleadmin.comLaboratory AssistantThe Laboratory Assistant position is a joint-hire between the laboratories of Drs. Tigist Tamir and Chrystal Starbird in the Department of Biochemistry and Biophysics at UNC Chapel Hill. This is a sup... 086
Reposted by Neel ShahTina Perica @glukozica.bsky.social · 27/05/2026My department is open to hosting a Starting Grant lab. If you are eligible and want to do biochemistry broadly defined (we like everything, from biophysics to systems biology!) consider applying. My department is the best and Zurich is pretty good too! www.nature.com/naturecareer...nature.comAssistant professor for ERC Starting Grant in Biochemistry - Zurich (CH) job with University of Zurich (UZH) | 12859194Assistant professor for ERC Starting Grant in Biochemistry (non-tenure track) 21110
Neel Shah @nshahlab.bsky.social · 23/05/2026Happy to share this paper from our lab, with @jlmcfalinefigueroa.bsky.social’s group, out in its final form at Science Advances! Big congrats to lead authors Anne van Vlimmeren and Ross Giglio! www.science.org/doi/10.1126/...science.orgMultiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variantsRNA sequencing of cells expressing SHP2 disease mutants shows how changes to enzyme structure cause different cellular outcomes. 081
Reposted by Neel ShahIrving Institute for Cancer Dynamics @cancerdynamics.bsky.social · 22/05/2026New research from the @jlmcfalinefigueroa.bsky.social and @nshahlab.bsky.social groups, recently published in Science Advances, uncovers novel mechanisms by which SHP2 mutations disrupt cellular processes. This work may help pave the way toward future therapies for patients > bit.ly/4nGsVZm 054
Neel Shah @nshahlab.bsky.social · 14/05/2026Excited to share our lab's latest preprint, led by graduate student Minhee Lee, with contributions from former undergrad Zijing Wang and grad student Andrew Johns! We show that substrate specificity information coupled with AF3 models can be used to design selective tyrosine kinase inhibitors. 152
Reposted by Neel ShahChris Parker @chrisgparker.bsky.social · 05/05/2026Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!nature.comPosttranslational modifications remodel proteome-wide ligandability - Nature Chemical BiologyA chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor... 0289
Reposted by Neel ShahLorenz Lab @sonjalorenzlab.bsky.social · 04/05/2026Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...mpinat.mpg.dePhD student or Postdoc (f/m/d)- Understanding and manipulating ubiquitin ligase specificities -The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi... 01916
Reposted by Neel ShahAmy Weeks @amyweeks.bsky.social · 28/04/2026Excited that our paper on enzymatic bromination of peptides is now online at ACS Chemical Biology! Led by Haley Bridge, we showed that the flavin-dependent halogenase RebH and its variants can be used for late-stage chemoenzymatic diversification of bioactive peptides: pubs.acs.org/doi/10.1021/...pubs.acs.orgEnzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura CouplingFlavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li... 13614
Reposted by Neel ShahProtein Society @proteinsociety.bsky.social · 14/04/2026🏆 2026 Protein Society Award Winners Celebrating the scientists shaping the future of protein science 👏 🎤 Hear from this year’s award winners live at #PS40 in Boston this July 🔗 Learn more + register: proteinsociety.org/annual-symposium #TheProteinSociety 073
Reposted by Neel Shahjp flores (he/him) @jpflores.rbind.io · 18/03/2026Check out my new piece in @sciencepolitics.bsky.social ! “We’re Training Scientists for a World That No Longer Exists” sciencepolitics.org/2026/03/18/w...sciencepolitics.orgWe’re Training Scientists for a World That No Longer Exists - Science PoliticsScience can help address pressing challenges, but only if we train scientists to communicate in the places people actually form beliefs. 184
Reposted by Neel ShahJason Zhang Lab @ UCLA @jasonzhanglab.bsky.social · 11/03/2026The first publication while at UCLA! We developed and utilized generative AI protein design methods for targeting the disordered and highly charged C-terminus of RAS to generate RAS isoform specific binders/inhibitors: www.sciencedirect.com/science/arti...sciencedirect.comDe novo design of Ras isoform selective bindersThe four major isoforms encoded by RAS proto-oncogenes are differentially associated with cancer, but there are few isoform-specific binding reagents … 0103
Reposted by Neel ShahAlex Guseman @alexguseman.bsky.social · 06/03/2026I am REALLY excited to share this manuscript from my group now on bioarxiv. Here we used the OAA lectin scaffold to ask can lectins be evolved to have specific interactions for defined glycan structures . www.biorxiv.org/content/10.6...biorxiv.org 2189
Reposted by Neel ShahKathrin Lang @klanglab.bsky.social · 11/03/2026🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4cell.comA modular genetic code expansion approach to site-specific lysine acylationsA modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel... 25115
Reposted by Neel ShahKate Carroll @carrollchembiol.bsky.social · 02/03/2026Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6t.cohttps://doi.org/10.1038/s41589-026-02145-w 064
Reposted by Neel ShahIn Preparation @inprep.bsky.social · 02/03/2026substack.comStructural Biologist Tells Uber Driver AlphaFold Can’t Model DynamicsBOSTON—Approximately four minutes into a 12-minute ride from Kendall Square to Logan Airport, structural biologist Dr. 042
Reposted by Neel ShahJoan Gizzio @joanzone.bsky.social · 23/02/2026So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore 2135
Reposted by Neel ShahMiriam Posner @miriamposner.com · 22/02/2026BLEAK. Bleak. I’d been paying attention to Columbia selling out its governance to the Trump admin, not so much its stance on AI. www.columbiaspectator.com/opinion/2026... 35585188
Reposted by Neel ShahRoland Dunbrack 🏳️🌈 @rolanddunbrack.bsky.social · 22/02/2026Great work from post-doctoral fellow @joanzone.bsky.social: New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation. doi.org/10.64898/202... 1268
Reposted by Neel ShahNick Polizzi @nickpolizzi.bsky.social · 20/02/2026I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school. 11113
Reposted by Neel ShahLaura Dattaro @ldattaro.bsky.social · 16/02/2026Hi #chemsky! If you're navigating the NIH grant application process right now—or if you decided not to—I'd love to hear from you. Email: LDattaro@proton.me Signal: LDattaro.73 048
Reposted by Neel ShahAdmirable Women @admirablewomen.bsky.social · 26/01/2026Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM 326592
Reposted by Neel ShahBrent Stockwell @brentstockwell.bsky.social · 25/01/2026Here is reading for this snowy day: Congrats to Hanna Feinsod on publication of our perspective in Ferroptosis & Oxidative Stress on 3 major unanswered questions in #ferroptosis! www.sciexplor.com/articles/fos...sciexplor.comFundamental mechanism of ferroptosis: Three unanswered questionsFerroptosis, an iron-dependent form of regulated cell death (RCD) driven by lipid peroxidation, has been extensively studied since its conceptualization in 2012 and has been suggested as a therapeutic... 031
Neel Shah @nshahlab.bsky.social · 21/01/2026Congrats, @sharpe-lab.bsky.social, on a really great paper! Pervananadate is such a pervasive reagent in pY signaling studies - this work really made me think more deeply about its use! Also, tyrosine kinases and phosphatases, what’s not to love? I enjoyed writing about it! 040
Reposted by Neel ShahThe Rockefeller University @rockefeller.edu · 13/01/2026For decades, scientists have designed drugs to slow down or block enzymes, but Tarun Kapoor wondered if tackling some diseases requires the opposite approach. We spoke with Kapoor about why speeding up an enzyme is so difficult, and how his team is cracking this problem. See the full Q&A here:rockefeller.eduScientists have gotten good at blocking enzymes to treat disease. Now can they speed them up? - NewsEnzymes are the molecular machines that power life; they build and break down molecules, copy DNA, digest food, and drive virtually every chemical reaction in our cells. For decades, scientists have d... 074
Neel Shah @nshahlab.bsky.social · 07/01/2026My awesome colleagues at Barnard Chemistry are look to recruit an Early-Career Faculty fellow in computational chemistry. This is a 2-year residential teaching and research fellowship. Please share broadly! #chemjobs barnard.wd1.myworkdayjobs.com/en-US/Facult...barnard.wd1.myworkdayjobs.comBarnard Early-Career Faculty Fellow, ChemistryIf you are a current Barnard College employee, please use the internal career site to apply for this position. Job: Barnard Early-Career Faculty Fellow, Chemistry Barnard College seeks a full-time (ea... 033
Reposted by Neel ShahBalyn Zaro @balynzaro.bsky.social · 06/01/2026Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...biorxiv.orgNinhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive argininesCovalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a... 34721
Reposted by Neel ShahBiochemical Society @biochemsoc.bsky.social · 02/01/2026Unsure how to gain your first peer review opportunity, or keen to improve your feedback? Catch up on our latest ECR webinar and gain practical tips from Biochemical Society Editors-in-Chief on writing and submitting a high-quality review!🧪 ow.ly/5pWZ50XNBJs 0104
Reposted by Neel ShahNY-CURES @nycures.bsky.social · 24/11/2025📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTWc.orgSign the PetitionSupport a New York State Biomedical Institute for a Healthier, More Affordable Future 13938