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Neel Shah

@nshahlab.bsky.social
751 followers 596 following 90 posts

Associate Professor at Columbia Chemistry. PI of a chemical biology lab full of awesome people. Internal conflicts: Chemist or biologist? Kinase or phosphatase? Lab website: shahlab.wixsite.com/home ORCiD: 0000-0002-1186-0626

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Reposted by Neel Shah
Dirk Trauner @dirktrauner.bsky.social · 14/09/2026
The Department of Chemistry at the University of Pennsylvania invites applications for a tenure-track position at the rank of Assistant Professor in the broadly defined area of organic chemistry. I have the honor of chairing the search committee. apply.interfolio.com/192648
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Andres Bendesky @bendeskylab.com · 11/09/2026
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Mike Giuliano @drmikeg83.bsky.social · 28/08/2026
Come join us and our great students in Charleston! The CofC Dept. of Chemistry and Biochemistry is hiring a tenure-track assistant prof in organic chemistry. We STRONGLY encourage organic chemists across the discipline to apply! I'm happy to answer any questions #chemsky jobs.cofc.edu/postings/17937
jobs.cofc.edu
Assistant Professor of Chemistry and Biochemistry (organic)
Tenure-Track Assistant Professor in Organic Chemistry. The Department of Chemistry and Biochemistry at the College of Charleston invites applications for a tenure-track faculty position beginning in F...
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Mary Munson @marymunson4.bsky.social · 26/08/2026
Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).
umassmed.edu
Munson Lab | Home | BMB | UMass Chan Medical School
The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...
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Neel Shah @nshahlab.bsky.social · 25/08/2026
Excited to share our lab's latest paper led by recent graduate Minhee Lee, PhD., out in its final form at ACS Chemical Biology! Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases pubs.acs.org/acbcct/artic...
pubs.acs.org
Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases
AbstractProtein tyrosine kinases are important regulators of cell signaling, and aberrant kinase activity contributes to many human diseases, including can
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Reposted by Neel Shah
George Burslem @gburslem.bsky.social · 24/08/2026
It's been a great couple of weeks for publications from the lab! First up we have a generalizable induced proximity system for gain of function PTM editing exemplified by acetylation and led by @briehp.bsky.social pubs.acs.org/acbcct/artic...
pubs.acs.org
General Strategy for Controlling Functional Lysine Acetylation via Induced Proximity
AbstractAssigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events
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Ruben Gonzalez @rubenlgonzalez.bsky.social · 23/08/2026
The NSF is on track to award 30% fewer new research grants this year—the lowest number in four decades. Basic science is the foundation of future medicines, technologies, and prosperity. We must fund it. www.nature.com/articles/d41...
nature.com
Exclusive: NSF set to issue lowest number of new grants in four decades
The US science-funding agency is withholding $1 billion of its budget so that the money can go to a special White House project.
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 09/08/2026
Our paper on the active form of human protein kinases is out in Biochemical Journal from @biochemsoc.bsky.social . Great experience with the journal, unlike another journal that begins with "Nat" and ends with "omms." doi.org/10.1042/BCJ2... Made the cover in August (paper came out in July)...
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Mike Giuliano @drmikeg83.bsky.social · 03/08/2026
Hey Chemists, we’re hiring, come join us! See the original post below, happy to answer questions. Charleston is a beautiful place to live, and we have great facilities, students, and colleagues! #chemsky @chemjobber.bsky.social
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Fantauzzo Lab @fantauzzolab.bsky.social · 09/07/2026
This piece really resonated with me - so often I've wished I could go back and assure my younger self that things will (mostly) work out: www.science.org/content/arti...
science.org
To my younger self, the overwhelmed new professor: You will make it
How this scientist navigated the tough decisions and personal strain of starting a lab
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Neel Shah @nshahlab.bsky.social · 09/07/2026
Congrats to Dr. Andrew Johns, the 7th PhD from our lab! He gave a great talk describing his project on using photo-crosslinking to identify tyrosine phosphatase substrates. His work dropped on bioRxiv yesterday: bsky.app/profile/nsha...
Andrew Johns giving his thesis defense presentation.Andrew and Neel celebrating Andrew's thesis defense.
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Neel Shah @nshahlab.bsky.social · 07/07/2026
Excited to share this new preprint, led by graduate student Andrew Johns! We used amber suppression to install photocrosslinkers in PTP1B to enable identification of new substrates. Our method detects localization- and stimulation-dependent changes in substrate scope. www.biorxiv.org/content/10.6...
biorxiv.org
In situ identification of substrates of the protein tyrosine phosphatase PTP1B using site-specific photo-crosslinking
Protein tyrosine phosphorylation is critical for cellular function, and aberrant phosphorylation is tied to a wide range of human diseases. Identifying the substrates of protein tyrosine phosphatases,...
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Neel Shah @nshahlab.bsky.social · 06/07/2026
Wow, this looks awesome and will be a great resource to anyone studying protein-protein interactions, SLiMs, and cell signaling! Excited to dig into this. Congrats to everyone involved!
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 23/06/2026
“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...
inpreparation.substack.com
Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination
By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University
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Karolin Luger @nucleosomepolice.bsky.social · 20/06/2026
Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...
nytimes.com
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
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Neel Shah @nshahlab.bsky.social · 14/06/2026
I love New York.
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Neel Shah @nshahlab.bsky.social · 13/06/2026
Congrats, Weeks lab! Very enabling platform and a cool study!
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Neel Shah @nshahlab.bsky.social · 07/06/2026
New crew, new photo, still awesome to work with!
Photo of Shah Lab members:
back row (left to right): Minhee, Andrew, Zach, Paramesh, Neel, Devon
front row (left to right): Zach, Annalise, Katherine, Yethmie, Loren, Mackenzie
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Neel Shah @nshahlab.bsky.social · 04/06/2026
Happy to introduce PhD #6, aka Dr. Minhee Lee! He gave a fantastic talk today and did a great job defending his dissertation!
Picture of Neel and Minhee in front of congratulations sign at Minhee’s PhD defense party.Picture of Minhee giving his PhD defense talk.
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Caroline Lynn Kamerlin ☀️ @lynnkamerlin.bsky.social · 01/06/2026
Are you interested in understanding protein dynamics and allostery in biomedically relevant "loopy" enzymes? We are looking for postdocs to join our group at GT for both applied and method development work. If you are interested, please email me your CV, cover letter, and details of 2-3 referees.
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FASEB @faseborg.bsky.social · 30/05/2026
⌛ Don’t miss the June 1 registration deadline for #ProteinPhosSRC! This conference brings together scientists from around the world to share new discoveries in protein phosphorylation, disease mechanisms, and therapeutic development. Register now! buff.ly/YxSgh5Y
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Chrystal Starbird @drstarbird.bsky.social · 29/05/2026
We are hiring! This is a joint Lab Assistant position with @phosphotig.bsky.social ‘s lab. If you are organized and creative, enjoy learning new things, and if working with two great teams of scientists sounds appealing, please apply! unc.peopleadmin.com/postings/319...
unc.peopleadmin.com
Laboratory Assistant
The Laboratory Assistant position is a joint-hire between the laboratories of Drs. Tigist Tamir and Chrystal Starbird in the Department of Biochemistry and Biophysics at UNC Chapel Hill. This is a sup...
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Tina Perica @glukozica.bsky.social · 27/05/2026
My department is open to hosting a Starting Grant lab. If you are eligible and want to do biochemistry broadly defined (we like everything, from biophysics to systems biology!) consider applying. My department is the best and Zurich is pretty good too! www.nature.com/naturecareer...
nature.com
Assistant professor for ERC Starting Grant in Biochemistry - Zurich (CH) job with University of Zurich (UZH) | 12859194
Assistant professor for ERC Starting Grant in Biochemistry (non-tenure track)
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Neel Shah @nshahlab.bsky.social · 23/05/2026
Happy to share this paper from our lab, with @jlmcfalinefigueroa.bsky.social’s group, out in its final form at Science Advances! Big congrats to lead authors Anne van Vlimmeren and Ross Giglio! www.science.org/doi/10.1126/...
science.org
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants
RNA sequencing of cells expressing SHP2 disease mutants shows how changes to enzyme structure cause different cellular outcomes.
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Irving Institute for Cancer Dynamics @cancerdynamics.bsky.social · 22/05/2026
New research from the @jlmcfalinefigueroa.bsky.social and @nshahlab.bsky.social groups, recently published in Science Advances, uncovers novel mechanisms by which SHP2 mutations disrupt cellular processes. This work may help pave the way toward future therapies for patients > bit.ly/4nGsVZm
Figure depicting the research of the McFaline-Figueroa and Shah groups on SHP2 mutations. They generated an array of cells and examined how they responded to growth factor stimulation as a function of SHP2 mutations.
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Neel Shah @nshahlab.bsky.social · 14/05/2026
Excited to share our lab's latest preprint, led by graduate student Minhee Lee, with contributions from former undergrad Zijing Wang and grad student Andrew Johns! We show that substrate specificity information coupled with AF3 models can be used to design selective tyrosine kinase inhibitors.
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Chris Parker @chrisgparker.bsky.social · 05/05/2026
Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!
nature.com
Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology
A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...
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Lorenz Lab @sonjalorenzlab.bsky.social · 04/05/2026
Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...
mpinat.mpg.de
PhD student or Postdoc (f/m/d)- Understanding and manipulating ubiquitin ligase specificities -
The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...
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Amy Weeks @amyweeks.bsky.social · 28/04/2026
Excited that our paper on enzymatic bromination of peptides is now online at ACS Chemical Biology! Led by Haley Bridge, we showed that the flavin-dependent halogenase RebH and its variants can be used for late-stage chemoenzymatic diversification of bioactive peptides: pubs.acs.org/doi/10.1021/...
pubs.acs.org
Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling
Flavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li...
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Protein Society @proteinsociety.bsky.social · 14/04/2026
🏆 2026 Protein Society Award Winners Celebrating the scientists shaping the future of protein science 👏 🎤 Hear from this year’s award winners live at #PS40 in Boston this July 🔗 Learn more + register: proteinsociety.org/annual-symposium #TheProteinSociety
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jp flores (he/him) @jpflores.rbind.io · 18/03/2026
Check out my new piece in @sciencepolitics.bsky.social ! “We’re Training Scientists for a World That No Longer Exists” sciencepolitics.org/2026/03/18/w...
sciencepolitics.org
We’re Training Scientists for a World That No Longer Exists - Science Politics
Science can help address pressing challenges, but only if we train scientists to communicate in the places people actually form beliefs.
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Jason Zhang Lab @ UCLA @jasonzhanglab.bsky.social · 11/03/2026
The first publication while at UCLA! We developed and utilized generative AI protein design methods for targeting the disordered and highly charged C-terminus of RAS to generate RAS isoform specific binders/inhibitors: www.sciencedirect.com/science/arti...
sciencedirect.com
De novo design of Ras isoform selective binders
The four major isoforms encoded by RAS proto-oncogenes are differentially associated with cancer, but there are few isoform-specific binding reagents …
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Alex Guseman @alexguseman.bsky.social · 06/03/2026
I am REALLY excited to share this manuscript from my group now on bioarxiv. Here we used the OAA lectin scaffold to ask can lectins be evolved to have specific interactions for defined glycan structures . www.biorxiv.org/content/10.6...
biorxiv.org
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Kathrin Lang @klanglab.bsky.social · 11/03/2026
🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4
cell.com
A modular genetic code expansion approach to site-specific lysine acylations
A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...
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Kate Carroll @carrollchembiol.bsky.social · 02/03/2026
Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6
t.co
https://doi.org/10.1038/s41589-026-02145-w
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In Preparation @inprep.bsky.social · 02/03/2026
substack.com
Structural Biologist Tells Uber Driver AlphaFold Can’t Model Dynamics
BOSTON—Approximately four minutes into a 12-minute ride from Kendall Square to Logan Airport, structural biologist Dr.
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Joan Gizzio @joanzone.bsky.social · 23/02/2026
So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore
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Miriam Posner @miriamposner.com · 22/02/2026
BLEAK. Bleak. I’d been paying attention to Columbia selling out its governance to the Trump admin, not so much its stance on AI. www.columbiaspectator.com/opinion/2026...
Last month, University of Wisconsin-Madison Chancellor Jennifer Mnookin approved a proposal to establish a College of Computing and Artificial Intelligence funded by private corporations and philanthropy.
Mnookin said the move was a response to the inevitable creep of artificial intelligence into all disciplines of academia. Rather than reject AI, she envisioned a university that capitalized on this change by making artificial intelligence a "hub" connecting the humanities to computer science.On the first day of my economics elective this spring, my professor said we would be expected to use NotebookLM to pass his class. He had lengthened the coding assignments so that they would be doable only with the help of AI. The reading assignments were longer, too: ten 40-page papers per week, which he asked us to feed into AI for a summary rather than read ourselves. When it came to lectures, he told us to simply upload the slides to AI and ask it to teach us whatever he failed to explain properly in class.
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 22/02/2026
Great work from post-doctoral fellow @joanzone.bsky.social: New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation. doi.org/10.64898/202...
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Nick Polizzi @nickpolizzi.bsky.social · 20/02/2026
I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.
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Laura Dattaro @ldattaro.bsky.social · 16/02/2026
Hi #chemsky! If you're navigating the NIH grant application process right now—or if you decided not to—I'd love to hear from you. Email: LDattaro@proton.me Signal: LDattaro.73
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Admirable Women @admirablewomen.bsky.social · 26/01/2026
Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM
Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.
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Brent Stockwell @brentstockwell.bsky.social · 25/01/2026
Here is reading for this snowy day: Congrats to Hanna Feinsod on publication of our perspective in Ferroptosis & Oxidative Stress on 3 major unanswered questions in #ferroptosis! www.sciexplor.com/articles/fos...
sciexplor.com
Fundamental mechanism of ferroptosis: Three unanswered questions
Ferroptosis, an iron-dependent form of regulated cell death (RCD) driven by lipid peroxidation, has been extensively studied since its conceptualization in 2012 and has been suggested as a therapeutic...
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Neel Shah @nshahlab.bsky.social · 21/01/2026
Congrats, @sharpe-lab.bsky.social, on a really great paper! Pervananadate is such a pervasive reagent in pY signaling studies - this work really made me think more deeply about its use! Also, tyrosine kinases and phosphatases, what’s not to love? I enjoyed writing about it!
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Neel Shah @nshahlab.bsky.social · 14/01/2026
Congrats!!
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The Rockefeller University @rockefeller.edu · 13/01/2026
For decades, scientists have designed drugs to slow down or block enzymes, but Tarun Kapoor wondered if tackling some diseases requires the opposite approach. We spoke with Kapoor about why speeding up an enzyme is so difficult, and how his team is cracking this problem. See the full Q&A here:
rockefeller.edu
Scientists have gotten good at blocking enzymes to treat disease. Now can they speed them up? - News
Enzymes are the molecular machines that power life; they build and break down molecules, copy DNA, digest food, and drive virtually every chemical reaction in our cells. For decades, scientists have d...
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Neel Shah @nshahlab.bsky.social · 07/01/2026
My awesome colleagues at Barnard Chemistry are look to recruit an Early-Career Faculty fellow in computational chemistry. This is a 2-year residential teaching and research fellowship. Please share broadly! #chemjobs barnard.wd1.myworkdayjobs.com/en-US/Facult...
barnard.wd1.myworkdayjobs.com
Barnard Early-Career Faculty Fellow, Chemistry
If you are a current Barnard College employee, please use the internal career site to apply for this position. Job: Barnard Early-Career Faculty Fellow, Chemistry Barnard College seeks a full-time (ea...
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Balyn Zaro @balynzaro.bsky.social · 06/01/2026
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...
biorxiv.org
Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
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Biochemical Society @biochemsoc.bsky.social · 02/01/2026
Unsure how to gain your first peer review opportunity, or keen to improve your feedback? Catch up on our latest ECR webinar and gain practical tips from Biochemical Society Editors-in-Chief on writing and submitting a high-quality review!🧪 ow.ly/5pWZ50XNBJs
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NY-CURES @nycures.bsky.social · 24/11/2025
📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
c.org
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
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