iiinova — where your digital self keeps evolving

Jason Zhang Lab @ UCLA @jasonzhanglab.bsky.social · 12/06/2026

It was great to host Amgen for a joint meeting between the Zhang lab and @yamadahunter.bsky.social lab!

Jason Zhang Lab @ UCLA @jasonzhanglab.bsky.social · 30/04/2026

Excited to announce another publication (review) on de novo protein design! We cover the status quo, challenges, and future directions of protein design. Read here: www.nature.com/articles/s41...

nature.com

The past, present and future of de novo protein design - Nature

A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.

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Reposted by Jason Zhang Lab @ UCLA

Jason Zhang 🏳️‍🌈🇺🇸 @jasonzxzhang.bsky.social · 04/04/2026

Two of our senior scientists haven’t tried in-n-out so we went as a lab!

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Jason Zhang Lab @ UCLA @jasonzhanglab.bsky.social · 11/03/2026

The first publication while at UCLA! We developed and utilized generative AI protein design methods for targeting the disordered and highly charged C-terminus of RAS to generate RAS isoform specific binders/inhibitors: www.sciencedirect.com/science/arti...

sciencedirect.com

De novo design of Ras isoform selective binders

The four major isoforms encoded by RAS proto-oncogenes are differentially associated with cancer, but there are few isoform-specific binding reagents …

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