Reposted by Nikhil MilindSasha Gusev @sashagusevposts.bsky.social · 8hA searchable mapping between NIH study sections and program officers that doesn't suck. (Claude one-shot) sashagusev.github.io/po-study-sec... 22411
Reposted by Nikhil MilindGenetics Society of America @genetics-gsa.bsky.social · 29/09/2026The September issue of #GENETICS features work from @jonj-udd.bsky.social, @jeffspence.github.io, & Co which determines how genes associated with human recessive disorders fit the predictions of the classic theory of mutation–selection balance. 🔗 buff.ly/v8FpWWA 0115
Reposted by Nikhil MilindKacy Gordon @kacylynn.bsky.social · 28/09/2026JOB ALERT: UNC Bio is hiring 2 tenure track assistant profs doing molecular, cell, and dev bio. The search is intentionally broad, so please share widely and spread the word! Find more information and apply here: unc.peopleadmin.com/postings/325... Application review begins Nov 1. 04787
Reposted by Nikhil MilindMark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu 3150138
Reposted by Nikhil MilindAnita Devineni @anitadevineni.bsky.social · 29/09/2026The Emory Biology department is hiring a tenure-track ecologist at any rank. Deadline is Nov 1, link below! As I've said many times before, I couldn't ask for a more supportive department. Our faculty colleagues, dept chair, and admin staff are truly awesome ❤️ apply.interfolio.com/191783 2115142
Reposted by Nikhil MilindMaitreya Dunham @maitreya.bsky.social · 24/09/2026Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly. 110498
Reposted by Nikhil MilindYun S. Song @yun-s-song.bsky.social · 23/09/2026Please help spread the word! We are recruiting multiple Postdoctoral Fellows as part of the recently launched Bakar Computational Biomedicine Initiative (BCBI) at UC Berkeley and UCSF. BCBI website: bcbi.berkeley.edu Apply by Nov 1, 2026: berkeley.infoready4.com#freeformComp... (1/n)bcbi.berkeley.eduBakar Computational Biomedicine Initiative | Bakar Computational Biomedicine Initiative 12834
Reposted by Nikhil MilindMoi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 21/09/2026 📣 We are looking for a PhD student in 2027! Interested in studying rapid evolutionary dynamics of species in changing climates? Apply to the MOI LAB by Nov 19! Flyer below & tinyurl.com/flyerphdmoilab @ucberkeleyofficial.bsky.social @innovativegenomics.bsky.social @hhmi-science.bsky.socialtinyurl.com2027_PhD_RapidEvolutionGenomicsEcology-MoiLab_Berkeley-HHMIPhD positions: Rapid evolutionary genomics in plants Moi Exposito-Alonso Lab — www.moilab.science Assistant Professor, Freeman Hrabowski Scholar HHMI · Department of Integrative Biology · Innovative G... 03447
Reposted by Nikhil MilindRoshni Patel @roshnipatel.bsky.social · 14/09/2026These are of course very old questions with tremendous recent progress; we focus mostly on the recent progress and what it offers for the next era of studying human genetics in biobanks. Excited this preprint is out and we'd of course love to hear any thoughts! 12410
Reposted by Nikhil MilindJeff Spence @jeffspence.github.io · 14/09/2026@roshnipatel.bsky.social and I wrote about using biobanks to learn about evolution, and how those findings shape interpretations of association studies. We focused on estimating evolutionary constraint and relating relating selection on variants to selection on traits and include open questions. 15325
Reposted by Nikhil MilindarXiv q-bio.PE Populations and Evolution @qbiope-bot.bsky.social · 14/09/2026Jeffrey P. Spence, Roshni A. Patel: Insights into human evolution from large genetic biobanks arxiv.org/abs/2609.12297 arxiv.org/pdf/2609.12297 arxiv.org/html/2609.12297 078
Reposted by Nikhil MilindArbel Harpak @arbelharpak.bsky.social · 11/09/2026The Stengl-Wyer Postdoctoral Scholars Program is a great launch pad for early independence. Supports 3y of research at UT Austin. Inquiries to faculty sponsors welcome! Apply by 12/7/26 biodiversity.utexas.edu/about-center/endowments-biodiversity/stengl-wyer-endowment/stengl-wyer-scholars-programbiodiversity.utexas.eduStengl-Wyer Scholars ProgramStengl-Wyer Postdoctoral Scholars Program in Biodiversity at the University of Texas at Austin 012
Reposted by Nikhil Milindloic-yengo.bsky.social @loic-yengo.bsky.social · 11/09/2026I’m currently recruiting an experienced postdoc to join our team in Brisbane for at least two years, working on some cutting-edge problems in statistical genomics and genetic epidemiology. Link: uq.wd3.myworkdayjobs.com/en-GB/uqcare...uq.wd3.myworkdayjobs.comPostdoctoral Research Fellow/Research Fellow in Statistical GenomicsInstitute for Molecular Bioscience Full-time fixed-term position for up to 2.5 years Base salary will be in the range $106,293.57 - $113,659.72 + 17% super (Academic Level A) or $119,462.94 - $141,545... 11213
Reposted by Nikhil MilindMolly Przeworski @mollyprz.bsky.social · 11/09/2026Job opportunity at Columbia U., in "any combination of field, experimental, computational, or theoretical approaches to study fundamental questions in evolutionary biology". 03531
Reposted by Nikhil MilindAndres Bendesky @bendeskylab.com · 11/09/2026We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 082105
Reposted by Nikhil MilindGraham Coop @gcbias.bsky.social · 10/09/2026I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding 2119183
Reposted by Nikhil MilindYun S. Song @yun-s-song.bsky.social · 09/09/2026We are thrilled to share that our GPN-Star manuscript is now published and freely available: doi.org/10.1038/s415... (1/n)doi.orgPredicting genome-wide functional constraints with GPN-Star - NatureGPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species... 112246
Reposted by Nikhil MilindJonathan Pritchard @jkpritch.bsky.social · 09/08/2026Must-know numbers in human genetics -- As many of you know, I'm writing a free online textbook in human genetics. In this blog post I cover a key skill for genome scientists from that book: how to use mental math to figure out key genome properties. jkpritchard.substack.com/p/on-fermi-p...jkpritchard.substack.comOn Fermi Problems in Human Geneticsand some very useful numbers about human genomes to get you started! 918570
Reposted by Nikhil MilindEmma Dann @emmamarydann.bsky.social · 28/08/2026Our work on systematic perturb-seq of primary human T cells is now out in Cell 🎉 www.cell.com/cell/fulltex... It's been a privilege to work with @ronghuizhu.bsky.social between @jkpritch.bsky.social @marsonlab.bsky.social labs, with a dream-team of co-authors ❤️ Highlights in preprint thread👇cell.comGenome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traitsA dynamic atlas of gene regulation was generated by perturbing every expressed gene across 22 million primary human CD4+ T cells under resting conditions and following re-stimulation. The resulting ma... 14620
Reposted by Nikhil MilindJonathan Pritchard @jkpritch.bsky.social · 29/08/2026Genome-scale perturb-seq in human T cells. Our fantastic postdocs @ronghuizhu.bsky.social and @emmamarydann.bsky.social have done great work here to show the power and opportunities of perturb-seq in primary cells. This is part of a wonderful long-term collaboration with @marsonlab.bsky.social 1278
Reposted by Nikhil MilindMichelle Facette @mfacette.bsky.social · 28/08/2026UMass Amherst Dept of Biology is hiring a TT faculty member in Evolutionary Biology! careers.umass.edu/jobs/assista... We have a diverse and wonderful dept - please consider joining us!careers.umass.eduAssistant Professor - Evolutionary Biology - Amherst, Massachusetts, United StatesTitle: Assistant Professor - Evolutionary Biology Executive Area: Academic Affairs College/School/MBU: College of Natural Sciences Department: Biology Work Location: Amherst Schedule: Full Time Work A... 065103
Reposted by Nikhil MilindAaron Quinlan (he/him) @aaronquinlan.bsky.social · 28/08/2026I am delighted to announce that The Department of Human Genetics at the University of Utah is continuing a multi-year recruiting initiative for multiple tenure-track faculty positions at the rank of Assistant Professor. Please share and consider applying! utah.peopleadmin.com/postings/208... 183101
Reposted by Nikhil MilindMarc Robinson-Rechavi @marcrr.bsky.social · 20/08/2026Not my vote but great choice 😎 www.theguardian.com/environment/...theguardian.comWinner of Invertebrate of the Year 2026 crowned – and it is the size of a grain of riceThe leaf sheep, a neon green solar-powered slug, has inspired at least one Pokémon character and triumphs in global ballot 011
Reposted by Nikhil MilindGuillaume Holley @guillaumeolesan.bsky.social · 20/08/2026I am delighted to present with @hannespetur.bsky.social our new study on the Icelandic pangenome reference HPRC-ICE. This work goes all the way from pangenome construction to disease association! (1/7) www.nature.com/articles/s41...nature.comAn Icelandic pangenome reference - NatureNewly developed methods enable construction of Icelandic haplotypes and mapping of population-scale short reads to a pangenome by reducing reference bias and improving discovery in low-mappability reg... 13216
Reposted by Nikhil MilindGraham Coop @gcbias.bsky.social · 12/08/2026Excited for @gabrielesgarlata.bsky.social’s new preprint on the Genome-Wide Effect of Drift and Selection over a Single Generation 1/n www.biorxiv.org/content/10.6...biorxiv.orgThe Genome-Wide Effect of Drift and Selection over a Single GenerationThe relative importance of genetic drift versus selection to evolutionary change has long been debated. This debate has mainly focused over long-time-scales (e.g. hundreds of thousands of generations)... 211562
Reposted by Nikhil MilindMoi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 14/08/2026Congratulations to @dortizba.bsky.social on a new collaborative Tansley Review in @newphyt.bsky.social! Predictive evolutionary genomics: principles, validation, and practice doi.org/10.1111/nph.... 0106
Reposted by Nikhil MilindJonathan Pritchard @jkpritch.bsky.social · 09/08/2026So, I've started a substack. I'll be writing about biology, but my first posts are about applying statistical methods to one of my hobbies: track fandom. In the first posts I describe the Pareto trade-off between a fast overall speed and finishing speed: jkpritchard.substack.com/p/greatest-1...jkpritchard.substack.comGreatest 1500m races? Fast times vs fast finishes, and the Pareto Frontier.A statistical analysis of how overall race speed relates to finishing speed. 2617
Reposted by Nikhil MilindMark Phillips @maphillips.bsky.social · 15/07/2026Oregon State University's Department of Integrative Biology is currently hiring up to three tenure-track faculty members, with an emphasis on organismal biology. Note: Previous links are no longer active due to a change in our hiring system. oregonstate.wd501.myworkdayjobs.com/OSU_Careers_...oregonstate.wd501.myworkdayjobs.comAssistant ProfessorDepartment: Special Instructions to Applicants: To ensure full consideration, applications must be received by 10/1/26. Applications will continue to be accepted after the full consideration date, unt... 176107
Reposted by Nikhil Milindadelaide tovar @adel-aide.bsky.social · 11/07/2026Delighted to share that I’ll be sticking around at Michigan to start my lab in the Department of Human Genetics! Starting in May 2027, the Tovar lab will use functional genomics to study transcription factor biology and regulatory network dynamics in complex disease. Stay tuned for more details… 12446
Reposted by Nikhil MilindTuuli Lappalainen @tuuliel.bsky.social · 10/07/2026We're recruiting! An open functional genomics postdoc position at @scilifelab-ngi.bsky.social / my lab / Robert Månsson lab. Top notch environment for technology and applications development in lovely Stockholm. Please spread the word or apply if interested: www.kth.se/lediga-jobb/...kth.seKTH | Postdoc in genomicsKTH jobs is where you search for jobs at www.kth.se. 01321
Reposted by Nikhil MilindJonathan Pritchard @jkpritch.bsky.social · 09/07/2026It was a lot of fun working with @nikhilmilind.dev and @jeffspence.github.io on this paper about how gene dosage relates to traits (and resolving a nice paradox along the way). Thanks Craig Smail for a great Preview article! 0276
Reposted by Nikhil MilindDr. Stepfanie Aguillón 😷 @s-m-aguillon.bsky.social · 08/07/2026Interested in joining a growing lab in LA? We’re hiring a postdoc!! Please spread the word to folks in your network and feel free to get in touch with any questions recruit.apo.ucla.edu/JPF11142 182100
Reposted by Nikhil MilindJeff Spence @jeffspence.github.io · 08/07/2026Craig Smail wrote up a really nice Preview of @nikhilmilind.dev's paper where we try to explain why large effect variants tend to affect traits in the same direction on average, which we think about in terms of the non-linearity of gene dosage response curves. www.cell.com/cell-genomic...cell.comGene dosage differences and non-linear impacts on complex traitsLarge differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by ... 2347
Reposted by Nikhil MilindJohn Doench @johndoench.bsky.social · 06/07/2026New preprint from the group, comparing CRISPRko and CRISPRi via a Perturb-seq readout: www.biorxiv.org/content/10.6...biorxiv.orgDirect comparison of CRISPR knockout and interference with Perturb-seqCRISPR knockout (CRISPRko) and CRISPR interference (CRISPRi) are two workhorse technologies for loss-of-function studies, yet direct comparisons between the two are scant relative to their widespread ... 14117
Reposted by Nikhil MilindGene Shackman @gsociology.bsky.social · 02/07/2026Here is a request to find an organization, university, etc, to host Epi Info, a free to use data and statistics package, widely used in epidemiology and public health. #statistics #epiinfo #dataanalysis #statisticalsoftware 033
Reposted by Nikhil MilindMegan Dennis @mydennis.bsky.social · 26/06/2026Our previously preprinted study "Influence of cis-regulatory elements on expression divergence in human segmental duplications" is now published in @genomeresearch.bsky.social! Please check it out: genome.cshlp.org/content/earl...genome.cshlp.org 12110
Reposted by Nikhil MilindJeff Spence @jeffspence.github.io · 22/06/2026Excited to see @jonj-udd.bsky.social's fantastic work out @genetics-gsa.bsky.social. Selection in _heterozygotes_ is the primary force shaping allele frequencies of loss-of-function mutations in humans, even in genes only associated with purely recessive diseases. 🧪🧬 doi.org/10.1093/gene...doi.orgAllele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in HeterozygotesAbstract. The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model pred 26643
Nikhil Milind @nikhilmilind.dev · 22/06/2026Super interesting work by @jonj-udd.bsky.social and @jeffspence.github.io is now out in Genetics! 0124
Reposted by Nikhil MilindJeff Spence @jeffspence.github.io · 22/06/2026This paper also continues my streak of having the best experiences at #GENETICS (@genetics-gsa.bsky.social). Timely and incredibly thoughtful and thorough reviews. Thanks to @jnovembre.bsky.social and Nick Barton for handling our paper and the reviewers for helping us make our paper better. 181
Reposted by Nikhil MilindDr. Carly Kenkel @drcarl.bsky.social · 16/06/2026Aspiring Eco-Evo PhD students - check out the Simons Graduate Fellowships! it's a full ride!! 🧪https://www.simonsfoundation.org/grant/simons-graduate-fellowships-in-ecology-and-evolution/simonsfoundation.orgSimons Graduate Fellowships in Ecology and EvolutionThe purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo... 11729
Reposted by Nikhil MilindTorsten Günther @trstngnthr.bsky.social · 16/06/2026I am recruiting a PhD student (fully funded, 4yrs) to analyze modern 🧬 and ancient 🦴 genomic data from humans and domestic animals 🐑 Please share, I am happy to chat at #ICP2026 or #SMBE2026 this summer www.uu.se/en/about-uu/...uu.sePhD student position in Population Genomics - Uppsala UniversityPhD student position in Population Genomics , Department of Organismal Biology, Uppsala University 183106
Reposted by Nikhil MilindEuropean Society of Human Genetics @eshg.bsky.social · 16/06/2026🏆 Congratulations to Tuuli Lappalainen, ESHG Award Lecturer 2026! In her Award Lecture, Professor Lappalainen will discuss the next steps in interpreting these effects and the tools that will help researchers uncover the molecular mechanisms underlying genetic variation. #Genetics #eshg2026 04210
Reposted by Nikhil MilindSophie Jean Walton @sophiejwalton.bsky.social · 10/06/2026Excited to be at #PEQG26! I have a poster tonight on measuring selection on intraspecies variation in large microbial communities (415W), would love to hear what folks think! 1216
Reposted by Nikhil MilindYun Deng @yundeng.bsky.social · 09/06/2026#PEQG26 folks! I will be presenting my postdoc project with @jkpritch.bsky.social and @jeffspence.github.io about inferring population structure dynamics over time with tensor decomposition on ARG. The talk will be at the James Crow Talk session on Wednesday. Look forward to seeing everyone there! 24713
Reposted by Nikhil MilindHank Greely @hankgreely.bsky.social · 09/06/2026@nature.com on Egli's human embryos base editing. www.nature.com/articles/d41... Quotes me on worries about risky efforts. Egli says that would be premature; yes, that's my point. I also agree w/Fyodor Urnov's that preimplantation testing is (almost always) a better solution even if this proves safenature.comPrecise genome editing of human embryos triggers praise and alarmThe ‘base editing’ technique that researchers used is far from ready for the clinic, but critics worry that it will spur a rush to commercialize the approach. 133
Reposted by Nikhil MilindJoanna Masel @joannamasel.bsky.social · 03/06/2026Our new paper doi.org/10.1098/rspb... on long-term genetic threats to small populations finds that "mutational meltdown" (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass.bsky.social @uliseshmc.bsky.social @jeremyjberg.bsky.social 1/5doi.orgExtinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulationAbstract. Habitat loss contributes to extinction risk in multiple ways. Genetically, small populations can face an ‘extinction vortex’—a positive feedback 313256
Reposted by Nikhil MilindJonathan Pritchard @jkpritch.bsky.social · 01/06/2026Combined Optical Pooled Screens and Perturb-seq! Great new work by Romain Lopez & Taka Kudo. This is one of a series of papers from our lab (here, with Aviv Regev) using perturbations to interpret human genetics; a key revelation for me is how transferable the mouse perturbs are to human genetics. 0266
Reposted by Nikhil MilindRomain Lopez @biologicalml.org · 01/06/2026🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities. www.biorxiv.org/content/10.6... 1279