Ahead of World Sexual Health Day on 4 September, guest editor Maxime Levasseur asks: where does sexuality fit within psychology?

Cellular development unfolds across both space and time, with lineage history influencing cellular identity and tissue organization. In this issue of Cell Stem Cell, Jia et al. combine CRISPR lineage recording with spatial transcriptomics to reconstruct the clonal relationships and spatial organization of cells during mouse development and cancer progression.

A large number of genes have been associated with risk of developing autism spectrum disorder (ASD). In this Review, State and colleagues examine the genetics and genomics of ASD and discuss findings ...

Immune dysregulation contributes to the pathophysiology of schizophrenia (SZ) and bipolar disorder (BD), but specific immune alterations remain unclea…

DNA origami enables the programmable self-assembly of nucleic acids into precisely defined nanostructures, yet the influence of primary base sequence on folding reliability remains incompletely understood. In particular, off-target interactions between scaffold and staple strands may introduce kinetic traps and reduce assembly yield, even when the intended Watson-Crick complementarity is preserved. Here we show that scaffold sequence strongly affects DNA origami assembly through the prevalence of off-target binding reactions implicit in the chosen base sequence. We developed a multi-objective computational framework that scores candidate scaffold sequences according to four classes of off-target interactions and selects variants predicted to minimise these effects for a given origami design. Using this approach, we identified both favourable and unfavourable scaffold regions from biological and synthetic sequences and tested them experimentally across 2D and 3D DNA origami structures.

We developed Purified components Optimized for Flexible protein expression using in vitro-produced translation factors, an automated platform that entirely decouples translational machinery production from living cells. By synthesizing and assembling components in vitro via robotic liquid handling, this modular system provides a scalable, cost-effective environment for high-throughput biofoundry workflows and the discovery of next-generation biomaterials.

The COVID vaccine was linked to a new side effect for older adults.

We sold out of the first print run! Please expect a short delay for reprinting. These packets of zines are a fundraiser for the Prairieland Defendants! Each packet comes...

Bitmine Immersion Technologies has announced that its ETH holdings have reached 5.62 million tokens, totaling an impressive $10.4 billion with various investments.

Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ∼40-50% of cases[1][1],[2][2]. However, current therapies fail ...

Discover how proper roof maintenance can safeguard your home and elevate its market value through expert advice from Matt Edwards in HelloNation's latest article.

Enterohemorrhagic Escherichia coli (EHEC) is a well-known foodborne pathogen that causes not only severe hemorrhagic diarrhea but also life-threatening complications such as hemolytic uremic syndrome…

Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...

Cancer stem cells (CSCs) shape immunosuppressive tumor microenvironments through diverse mechanisms. In this issue of Cancer Cell, Fan et al. demonstrate that CSC-derived extracellular vesicles promote regulatory T cell expansion and facilitate immune evasion. The mechanistic details reveal a therapeutic vulnerability that enhances responses to checkpoint blockade.

Nature Metabolism, Published online: 08 June 2026; doi:10.1038/s42255-026-01539-3To understand which neurons respond to and mediate the action of the amylin receptor agonist cagrilintide, the authors generated a spatially resolved transcriptomics atlas of the caudal brainstem in mice, rats and macaques. Follow-up work in rats identified brainstem Calcr/Prlh neurons as mediators of the long-term effects of cagrilintide.

Nature Microbiology, Published online: 15 June 2026; doi:10.1038/s41564-026-02389-1Purine bias is critical for gene expression in bacteria, preventing premature transcription in species that exhibit runaway transcription.

Dijkstra et al. show that our brain distinguishes imagination from reality by monitoring how strongly the fusiform gyrus is activated. When imagined and real images produce similar activity, people ca...

We, the undersigned organizations and individuals, are deeply alarmed by the rapid militarization of artificial intelligence (AI) technologies. AI systems embedded into military kill chains are accele...

The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of ...

A DNA-logic artificial cell wall that encapsulates cells, shielding them from freezing damage. Beyond physical protection, it instructs cells to activate internal repair and growth pathways after thawing. This bioinspired strategy enables effective, dimethyl sulfoxide-free preservation of living cells, enhancing their recovery for therapeutic applications.

FILM is a mid-infrared photothermal microscopy variant that involves optical boxcar demodulation-based illumination, denoising and spectral deconvolution. Its relatively gentle nature allows imaging o...

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibitin...

The divers, including a marine scientist and her daughter, were part of a research trip and were exploring an underwater cave system when they failed to resurface.

A device for simultaneous photometry and electrophysiology allows recordings in freely moving mice without restriction or inhibition of movement or entanglement of the fiber and cables.

What the creator of MSG and the world’s biggest toilet-maker have in common

This Review presents the formation of large extracellular vesicle (L-EV) subsets, highlighting that their contents and physiological relevance, for example, in intercellular communication, are driven ...

A total of 112 gigawatts of batteries were deployed around the world in 2025 — 10 times the amount added just four years prior.