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Muriel Derrien

@murielderrien.bsky.social
671 followers 502 following 24 posts

Scientist Human Gut microbiome @MIB_WUR 🇳🇱 - @DanoneResearch 🇨🇵 - now @RaesLab 🇧🇪 (@VIB_microbes @KU_Leuven). Opinions are my own.

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Reposted by Muriel Derrien
Waggoner Lab @labwaggoner.bsky.social · 30/09/2026
Microbiome signatures linked to cancer and treatment adverse events in a real-world cohort @cellcellpress.bsky.social @mayoclinic.org www.cell.com/cell/fulltex...
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Reposted by Muriel Derrien
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 30/09/2026
Genome-resolved ecology and evolution of the microbiome enabled by quantitative long-read metagenomics www.biorxiv.org/content/10.64898/20…
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Microbiome Virtual International Forum @microbiomevif.bsky.social · 29/09/2026
💫 #MVIF Season 6 💫 Feel free to join the keynotes by presenting your work! Abstract submission is open: www.microbiome-vif.org/en-US #MVIF is proudly supported by #illumina and @corundumsb.bsky.social and our non-commercial co-organizing partners Seerave Foundation and @sph.cuny.edu
MVIF Season 6
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Nature Communications @natcomms.nature.com · 24/09/2026
#Microbiome Human gut microbiome composition and microbial genomes vary strongly across 5 industrialized countries. Diet-microbiome links are partly shared but largely population-specific. The Human Diets and Microbiome Initiative (THDMI) #nutrition #PrecisionNutrition
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Five-country analysis of geographic and dietary drivers of gut microbiome composition and genomic variation - Nature Communications
In this study, authors show that human gut microbiome composition and microbial genomes vary strongly across five industrialized countries, with diet microbiome links that are partly shared but largely population-specific.
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David Bikard @dbikard.bsky.social · 21/09/2026
New paper from the lab, out in Nature Microbiology. We ran CRISPRi screens to ask what genes E. coli needs in order to live in a gut and what this can tell us about the gut environment itself. doi.org/10.1038/s41564-026-02471-8
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Ákos T Kovács @evolvedbiofilm.bsky.social · 19/09/2026
From resistance genes to resistance states and enzymatic context-dependence in antimicrobial resistance @cp-trendsmicrobiol.bsky.social by @frankaarestrup.bsky.social Saria Otani, Anne Meyer, and Thomas Bjarnsholt www.cell.com/trends/micro...
cell.com
From resistance genes to resistance states and enzymatic context-dependence in antimicrobial resistance
Antimicrobial resistance is often inferred from resistance genes and susceptibility phenotypes measured under standardized conditions. We argue that for many resistance genes, resistance is better vie...
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Reposted by Muriel Derrien
Waggoner Lab @labwaggoner.bsky.social · 18/09/2026
Dietary pectin remodels commensal bacterial surfaces to promote IgA-mediated protection from intestinal inflammation @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...
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Reposted by Muriel Derrien
Nature Microbiology @natmicrobiol.nature.com · 17/09/2026
Out Now! In vivo CRISPRi screens reveal Escherichia coli functional adaptations in the mouse gut #MicroSky
go.nature.com
In vivo CRISPRi screens reveal Escherichia coli functional adaptations in the mouse gut
Nature Microbiology, Published online: 17 September 2026; doi:10.1038/s41564-026-02471-8In vivo silencing of genes in E. coli strains using CRISPRi reveals specific genetic factors and metabolic adaptations that influence colonization in the mouse gut under variable physiological conditions.
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Reposted by Muriel Derrien
Trends in Microbiology @cp-trendsmicrobiol.bsky.social · 17/09/2026
Micronutrients, the gut microbiota, and infection susceptibility in infants
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Micronutrients, the gut microbiota, and infection susceptibility in infants
Micronutrient deficiencies are common during infancy, particularly in settings with a high burden of infectious diseases. At the same time, the developing infant gut microbiota is a key determinant of susceptibility to infection from both resident pathobionts and incoming enteric pathogens. Recent human and experimental studies suggest that micronutrients regulate this developing microbial ecosystem in a highly context-dependent manner, with effects varying according to developmental stage, nutritional status, intestinal location, and environmental exposure. In this review, we synthesise current evidence linking micronutrient-microbiota interactions to microbial competition and metabolism, epithelial barrier integrity, and mucosal immunity, and discuss how these interactions may shape susceptibility to enteric and invasive bacterial infections during infancy.
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Reposted by Muriel Derrien
Alan Walker @faecalmatters.bsky.social · 17/09/2026
Formal announcement of the 15th installment of the International Gut Microbiology Symposium series, running from June 1st to 3rd 2027: www.abdn.ac.uk/events/confe... We will look forward to welcoming old friends and new to Aberdeen next summer.
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Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · 14/09/2026
Just out! @kiranrpatil.bsky.social @lisamaierlab.bsky.social and I wrote about how compounds not considered antibiotics (pharmaceutical, dietary, industrial, agricultural) can still impact the #microbiome 🦠 and human #health nature.com/articles/s41575-026-01258-w @natrevgastrohep.nature.com
Diagram of how non-antibiotic chemicals (from food, drugs, industry, and farming) interact with gut bacteria. Left side lists each source with an example compound and its structure: carboxymethyl cellulose from diet, metformin from pharmaceuticals, perfluorooctanoic acid from industry, chlorpyrifos from agriculture. In the center, arrows connect host and microbiome in both directions, labeled "Pharmacoecology" and "Pharmacomicrobiomics." The right side shows six effects on bacteria: bioaccumulation, direct killing, growth inhibition, horizontal gene transfer, cross-sensitization, and cross-protection. Boxes along the bottom flag the variables that shape these outcomes: exposure timing and dose, host diet and physiology, and the microbiome's existing structure.
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Alex Crits-Christoph @acritschristoph.bsky.social · 06/09/2026
Transferable genetic toolsets for nonmodel gut Clostridia enable in vivo reversible control of metabolite production www.nature.com/articles/s41... A nice update to the Jin et al. 2022 paper from Chun-Jun Guo: now with many promoters for gut clostridiales, screened from native metatranscriptomes:
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Reposted by Muriel Derrien
Chassaing Laboratory @chassainglab.bsky.social · 31/08/2026
The deadline is coming for our international microbiome-focused symposium !!! Registration is FREE, and we are welcoming abstract submissions for posters and short presentations. Deadline : Sept 30th. research.pasteur.fr/en/event/int...
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Thomas Clavel @tclavel.bsky.social · 26/08/2026
Drawing on the team’s knowledge acquired over the years, we share our thoughts here on how to enhance microbiome research with FAIR collections of microbial strains: 🔥 www.nature.com/articles/s41... @nfdi4microbiota.bsky.social, @spp2474.bsky.social, @dsmz.bsky.social, @natmicrobiol.nature.com.
nature.com
A roadmap to create FAIR collections of microbial strains - Nature Microbiology
Here the authors propose guidance on the process of establishing a state-of-the-art collection of microorganisms, including project planning, strain deposition and the naming of new taxa.
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Reposted by Muriel Derrien
Alvaro Sanchez @asanchezlab.bsky.social · 21/08/2026
New preprint from the lab: The Latent Simplicity of Microbial Ecological Interactions www.biorxiv.org/content/10.6... We're excited about this one. We find that high-order microbial interactions often obey simple linear laws making microbial communities far more predictable than one might expect
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Microbiome Virtual International Forum @microbiomevif.bsky.social · 20/08/2026
Join Seerave & #MVIF Symposium: cassyni.com/s/mvif-oncob... and #MeetTheSpeakers Jen Wargo explores how gut & tumor microbes shape immunity, cancer biology & response to immunotherapy, and why fiber-fermenting bacteria + adequate dietary fiber are linked to better outcomes with checkpoint blockade.
cassyni.com
Microbiome Modifiers and Cancer Immunotherapy - Seerave & MVIF Symposium
## Seerave & MVIF Symposium: The Microbiome in Cancer Immunotherapy ## The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors, yet it remains one of the most underr...
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Prof. Ruth Ley FRS @microbiome.bsky.social · 19/08/2026
A great review by the great @staceyheaver.bsky.social - all about bacterial lipids and their interactions with the host 🧪🧫🦠
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Microbiome Virtual International Forum @microbiomevif.bsky.social · 19/08/2026
Seerave & #MVIF event cassyni.com/s/mvif-oncob... & #MeetTheSpeakers Rinse Weersma @weersmalab.bsky.social tackles a widely overlooked issue: Proton Pump Inhibitors, often prescribed without strong evidence & are increasingly linked to "oralization" of the gut microbiome. Join us to hear more!
cassyni.com
Microbiome Modifiers and Cancer Immunotherapy - Seerave & MVIF Symposium
## Seerave & MVIF Symposium: The Microbiome in Cancer Immunotherapy ## The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors, yet it remains one of the most underr...
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Reposted by Muriel Derrien
Microbiome Virtual International Forum @microbiomevif.bsky.social · 19/08/2026
. Seerave Foundation & #MVIF Symposium: cassyni.com/s/mvif-oncob... & #MeetTheSpeakers Bertrand Routy reviews PPIs, SSRIs, benzodiazepines, OTC drugs, probiotics: how do they shape the microbiome, and what does that mean for clinical outcomes? Join us!
cassyni.com
Microbiome Modifiers and Cancer Immunotherapy - Seerave & MVIF Symposium
## Seerave & MVIF Symposium: The Microbiome in Cancer Immunotherapy ## The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors, yet it remains one of the most underr...
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Reposted by Muriel Derrien
Microbiome Virtual International Forum @microbiomevif.bsky.social · 17/08/2026
Join Seerave & #MVIF Symposium cassyni.com/s/mvif-oncob... and #MeetTheSpeakers Laurence Zitvogel (Institut Gustave Roussy 🇫🇷) will talk about how gut dysbiosis contributes to cancer immunotherapy resistance, reviewing microbial signatures and stool/blood biomarkers and more!
cassyni.com
Microbiome Modifiers and Cancer Immunotherapy - Seerave & MVIF Symposium
## Seerave & MVIF Symposium: The Microbiome in Cancer Immunotherapy ## The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors, yet it remains one of the most underr...
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Reposted by Muriel Derrien
Microbiome @microbiomej.bsky.social · 17/08/2026
In #Microbiome Microbially derived glutathione from Eubacterium rectale alleviates oxidative stress and promotes intestinal epithelial recovery🦠 Read more➡️ doi.org/rjc8 #Microbes
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Trishla Sinha @trishlasinha.bsky.social · 13/08/2026
1/12 After years of work, we are incredibly excited to share our study, published yesterday in @nature.com : “Maternal influences on gut microbiome and health” 🎉🦠 www.nature.com/articles/s41... A thread on what we found 🧵👇
nature.com
Maternal influences on infant gut microbiome and health - Nature
The maternal gut microbiome is a predictor of infant eczema.
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Reposted by Muriel Derrien
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 09/08/2026
ICYMI: New online! Multidisciplinary Delphi consensus statement on minimal standards for clinical metadata and end points in microbiome studies
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Multidisciplinary Delphi consensus statement on minimal standards for clinical metadata and end points in microbiome studies
Nature Reviews Gastroenterology & Hepatology, Published online: 03 August 2026; doi:10.1038/s41575-026-01229-1In this Consensus Statement, an international panel of experts provides recommendations to harmonize metadata, sampling, analysis and end points in gut microbiome-based clinical research.
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Mateus lab @mateuslab.com · 08/08/2026
Bolor's paper is now out! Read the final story here: www.nature.com/articles/s41... See below 👇 for the main highlights
nature.com
Systematic profiling of growth interactions in human gut microbiome species - Nature Communications
Here, Buyanbadrakh et al. systematically map growth interactions among gut bacteria, revealing predominantly inhibitory effects, and identifying extracellular vesicles and pH modulation as mechanisms ...
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APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 07/08/2026
Standards help compare microbiome studies. @natrevgastrohep.nature.com sets out 15 recommendations from a Delphi process on metadata, samples and end points. Nine APC researchers at APC contributed through HMA. buff.ly/JM7a2XD @springernature.com #Microbiome @colinhillucc.bsky.social
Harmonization of clinical microbiome studies shown as a central microbial illustration linked to four key areas — anthropometric and bioclinical metadata, sample collection and processing, pre-analytical standards, and clinical end points — each depicted with a simple icon.
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Sara Mitri @saramitri.bsky.social · 04/08/2026
@massimoamicone.bsky.social giving a fantastic talk on evolutionary rescue in simple microbial communities at MEEHubs 2026 @meehubs.bsky.social #meehubs2026
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Bahtiyar Yilmaz @bahtiyil.bsky.social · 03/08/2026
A stool transplant delivers billions of microbes into a sick gut. Almost none move in for good. We followed donor-recipient pairs from whole communities down to single nucleotides, and found the gut runs a ruthless strain-level filter. Out now in Cell Reports 🧵 www.cell.com/cell-reports...
cell.com
Strain-level ecological filtering governs microbial colonization of the human gut
Baertschi et al. demonstrate that microbiota transplantation functions as a selective ecological filter. Although donor species frequently appear, only specific lineages achieve stable strain integrat...
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Nature Microbiology @natmicrobiol.nature.com · 29/07/2026
Out Now! Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice #MicroSky
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Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice
Nature Microbiology, Published online: 29 July 2026; doi:10.1038/s41564-026-02434-zLipidomics and proteomics in mice colonized with variable gut microbiota reveal an important role of gut microbes in restricting lipid uptake via triggering Myd88 signalling and the degradation of phosphatidylcholine in bile.
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Ákos T Kovács @evolvedbiofilm.bsky.social · 28/07/2026
See our review of bacteria-fungi interaction by Yixu Wang together with @jiyuxie.bsky.social from Zhihui Xu group (NAU) and Yicen Lin (Kunming) in Curr Opin Microbiol www.sciencedirect.com/science/arti... Microbiome Ecology at Institute of Biology Leiden / @leidenscience.bsky.social
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Climate, Ecology, War & More: Dr. Glen Barry BigEarthData.ai @bigearthdata.ai · 28/07/2026
Designing fiber-gut microbiome interactions with active learning ->Nature | More info at BigEarthData.ai | #SoilHealth #Microbiome
nature.com
Designing fiber-gut microbiome interactions with active learning
Agus, A., Clément, K. & Sokol, H. Gut microbiota-derived metabolites as central regulators in metabolic disorders. Gut 70, 1174–1182 (2021). Rinninella, E. et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms 7, 14 (2019). Das, B. & Nair, G. B. Homeostasis and dysbiosis of the gut microbiome in health and disease. J. Biosci. 44, 117 (2019). Schult, D. et al. Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19. Gut Microbes 14, 2031840 (2022). He, Y. et al. Effects of dietary fiber on human health. Food Sci. Hum. Wellness 11, 1–10 (2022). Tanes, C. et al. Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe 29, 394–407 (2021). Cantu-Jungles, T. M. & Hamaker, B. R. New view on dietary fiber selection for predictable shifts in gut microbiota. mBio 11, e02179-19 (2020). Oliver, A. et al. High-fiber, whole-food dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids. mSystems 6, 10–1128 (2021). Koh, A., De Vadder, F., Kovatcheva-Datchary, P. & Bäckhed, F. From dietary fiber to host physiology: short-chain fatty acids as...
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Ran Blekhman @blekhman.bsky.social · 26/07/2026
Everyone says AI will accelerate science. I don't think it will -- at least not in biology, and at least not soon. New post where I explain why, and how the productivity paradox can be resolved: blekhman.substack.com/p/why-ai-wil...
blekhman.substack.com
Why AI will not speed up science (yet)
You can see AI everywhere except in the productivity statistics
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 23/07/2026
Dear microbiome enthusiasts: I'm excited to be moving my lab to New York University this fall (& the NYU Institute for Engineering Health); with joint-appointment @isbscience.org I'm hiring a postdoc @ NYU to look at diet-driven evolution in the gut: apply.interfolio.com/189980 Please share! 🦠🤓
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Nature Microbiology @natmicrobiol.nature.com · 17/07/2026
Out Now! Predictable shifts in microbial species composition lead to community-wide robustness to environmental stress #MicroSky
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Predictable shifts in microbial species composition lead to community-wide robustness to environmental stress
Nature Microbiology, Published online: 17 July 2026; doi:10.1038/s41564-026-02422-3Environmental stress shifts microbial composition towards species with high growth rates, providing community-wide protection.
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Guillaume Méric @gmeric.bsky.social · 21/07/2026
New reading list for July, before the summer break! ☀️ Some studies that caught my eye in the field of microbiome research, population health, microbial genomics, ecology, evolution and other topics. Comments my own. Hope this will be useful to some of you! mericlab.com/blog/2026-07/
mericlab.com
Reading list: Intestinal nutrition, microbiome GWAS, GLP-1 & AI stuff
Some new articles in the reading list. I’ll probably do a little break for those during the summer holidays. Have a good one! (a) Microbiome and population health Genomic landscape of the human vagina...
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APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 20/07/2026
Where gut–brain research happens shapes what we know. A new paper in 𝐍𝐚𝐭𝐮𝐫𝐞 𝐌𝐞𝐧𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡 warns that relying mainly on high-income countries can distort mental health science and miss how environments shape the gut–brain axis. buff.ly/Obpj1Gm #Microbiome #MentalHealth
Where we study the gut-brain axis shapes what we know — UCC-branded cover for a Nature Mental Health perspective showing linked icons of a globe, an intestine, and a brain, a citation line, and four author headshots along the bottom.Most microbiome–gut–brain research is concentrated in high‑income countries: a world map shows dark orange shading across North America, Western Europe, China and Australia and pale blue/gray across much of Africa, parts of South America and Asia; headline and UCC logo present.Graphic titled "What could this bias change?" listing three impacts: distorting our understanding; missing natural experiments in lower-income countries; and narrowing what we can learn from environments and lifestyles.Poster titled "Why wider representation matters" with subtext "Research across more populations can strengthen scientific rigour and global relevance," above a world map linked by many connected user icons and the UCC logo.
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Microbiome Virtual International Forum @microbiomevif.bsky.social · 16/07/2026
The next season of #MVIF begins in September, but the archive remains open. We highlight #MVIF 47 and Mohammad Salimi's prize-winning presentation on mining putative peptides sourced from the human gut. Available now: www.youtube.com/watch?v=_BCZ...
youtube.com
Mohammad Salimi - Gut microbes may yield safe anticancer agents, aiding natural tumor. | MVIF45 S05
YouTube video by Microbiome Virtual International Forum
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Nature Portfolio @natureportfolio.nature.com · 16/07/2026
Heritage diets are disappearing as food systems homogenize. A Comment article in Nature Medicine discusses the World Diet Initiative, which offers a framework to document heritage diets and investigate their health effects before they are lost. go.nature.com/3Tj8F4U 🍎📃 🏺 🧪
This is figure 1, which shows the narrowing window to study vanishing dietary diversity.
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Will Shoemaker @shoestrapped.bsky.social · 09/07/2026
Great to see this important study published. For some time I've pointed to the preprint version when students ask about co-evolution between humans and their microbiota. "Limited codiversification of the gut microbiota within humans"
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Cameron Thrash @jcamthrash.bsky.social · 29/06/2026
Epistatic interactions inform rational design of synthetic microbial communities for bioremediation www.nature.com/articles/s41... #jcampubs
nature.com
Epistatic interactions inform rational design of synthetic microbial communities for bioremediation - Nature Microbiology
By taking into account the impacts of species presence, absence and potential interactions, synthetic soil microbial consortia are designed to degrade the toxic environmental contaminant bisphenol-A.
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Typas Lab @typaslab.bsky.social · 29/06/2026
How can we harness the vast functional diversity of microbes on our planet? Join us at EMBL Heidelberg from 8–10 December 2026 to hear about ongoing efforts to decode gene function and organisation in human gut microbes, and to present your own research. www.embl.org/about/info/c...
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Chassaing Laboratory @chassainglab.bsky.social · 25/06/2026
Dear #Microbiota lovers, please consider joining us for the international symposium marking the official launch of the @pasteur.fr Integrative Microbiome Program (IM2P), Nov30 / Dec1 2026, Institut Pasteur Paris !!! A exceptional panel of speakers in a vibrant environment!
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Paul Rainey @paulbrainey.bsky.social · 26/06/2026
I really value: the dynamics of community assembly on 2 contrasting C sources. Daily sampling of communities derived from compost & maintained over 8 wks. No difference in diversity maintained on simple or complex C. AmaZinG. 🙏 all enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com
Diverse Microbial Communities Assemble on Both Recalcitrant and Labile Carbon Sources
Taxonomically and functionally distinct communities assemble on cellulose and its monomer, glucose. Although single carbon sources were provided, high and comparable diversity was maintained in both ...
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Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 25/06/2026
Universal microbiome signature for CRC Large gut microbiome meta-analysis of colorectal cancer uncovers CRC microbiome signatures universal across ages & sequencing methods & modifiable by dietary interventions, ie fiber. www.cell.com/cell-host-mi...
cell.com
Meta-analysis reveals microbiome signatures for colorectal cancer that are universal across age groups and sequencing methods
Pekel, Karcher, et al. present the largest gut microbiome meta-analysis of colorectal cancer to date, integrating 6,779 amplicon and shotgun sequencing profiles. They establish a robust microbiome sig...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 24/06/2026
Voices of microbiome researchers in an artificial intelligence era @natmicrobiol.nature.com @atinsharma.bsky.social @natureportfolio.nature.com www.nature.com/articles/s41...
nature.com
Voices of microbiome researchers in an artificial intelligence era - Nature Microbiology
Nature Microbiology asked members of the Global Grants for Gut Health Colloquium about the impact artificial intelligence is having on their microbiome research.
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Cameron Thrash @jcamthrash.bsky.social · 22/06/2026
Precision culturomics enabled by unlabeled single-cell morphology and Raman spectra www.nature.com/articles/s41... #jcampubs
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Mizrahi Lab @mizrahilab.bsky.social · 18/06/2026
One mutation. 23 species. Total community reshuffle. A 4-yr synthetic bacterial community experiment shows a single species evolving antibiotic resistance was enough to flip the entire community's state. Great work all!! @teppo-h.bsky.social www.pnas.org/doi/10.1073/...
pnas.org
Evolution induced state shifts in a long-term microbial community experiment | PNAS
Biological communities are complex, dynamic systems that underpin ecosystem functionality, yet their long-term dynamics and predictability remain p...
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Segata Lab @cibiocm.bsky.social · 18/06/2026
🎉 Exciting news from our lab! cFMDv1.3.2 is now live. This release marks a significant expansion of cFMD: 📊 681 newly integrated food metagenomes from 22 public datasets 18,180 total MAGs across 4,125 metagenomes 54 countries (now including 🇲🇦) 100+ food-related studies 1/3
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 14/06/2026
Microbial inoculation accelerates post-fire soil recovery in a mixed conifer forest www.biorxiv.org/content/10.64898/20…
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Nature Medicine @natmed.nature.com · 05/06/2026
A phase 1b clinical trial compared fecal #microbiome transplant or a 15-strain live biotherapeutic product derived from the same donor & found similar efficacy & engraftment between treatments.
dlvr.it
15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial - Nature Medicine
A randomized, single-blind, parallel-group, phase 1b clinical trial compared fecal microbiota transplant or a 15-strain live biotherapeutic product (MTC01) derived from the same donor and found similar efficacy and engraftment between treatments.
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Nature Microbiology @natmicrobiol.nature.com · 02/06/2026
Out Now! Engineered Bacteroides thetaiotaomicron sense gut inflammation and deliver therapeutic molecules to alleviate colitis in mice #MicroSky
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Engineered Bacteroides thetaiotaomicron sense gut inflammation and deliver therapeutic molecules to alleviate colitis in mice
Nature Microbiology, Published online: 01 June 2026; doi:10.1038/s41564-026-02378-4Engineered Bacteroides thetaiotaomicron, Btbots, use a genetic AND circuit to sense nitric oxide and deoxycholic acid as inflammatory signal in the gut to release therapeutic molecules, TFF3 and IL-35, that alleviate colitis in mice.
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