Reposted by Marc van OostrumStefano Giandomenico @sgiando.bsky.social · 19hCan a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5 1117
Reposted by Marc van OostrumUCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 29/04/2026🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027. www.ucl.ac.uk/news/2026/ap... 04514
Reposted by Marc van OostrumJeremiah Cohen @jeremiahycohen.bsky.social · 13/04/2026Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1biorxiv.org 7254120
Reposted by Marc van OostrumPicotti Lab @picottilab.bsky.social · 07/04/2026We are delighted to announce that Paola Picotti has been awarded the Otto Naegeli prize for biomedical research! otto-naegeli-preis.ch 23113
Reposted by Marc van OostrumMara Mueller @muellermara.bsky.social · 19/02/2026Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪 510036
Reposted by Marc van OostrumBiozentrum, University of Basel @biozentrum.unibas.ch · 02/12/2025Autismus - Neuronale Besonderheiten und neue Behandlungswege #EinblickeBiozentrum by @scheiffelelab.bsky.social December 16, 2025. Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird. ow.ly/Wkme50RbjZc 122
Reposted by Marc van OostrumSwiss Network for Dementia Research @handle.invalid · 10/11/2025Thank you to 250+ participants, our keynote speakers, and the Event Forum team for an inspiring Swiss Dementia Forum. 011
Reposted by Marc van OostrumJakob Meier-Credo @meiercredo.bsky.social · 19/09/2025Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1... 15514
Reposted by Marc van OostrumMax Planck Institute for Brain Research @mpibrain.bsky.social · 10/07/2025🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social #neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40Pbit.lyErin M. Schuman Wins 2026 Nakasone Award 1123
Reposted by Marc van OostrumMaria Leptin @marialep.bsky.social · 17/06/2025Congratulations! The new Advanced Grant winners are great news. But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future! 45013
Reposted by Marc van OostrumIlaria Piazza lab @iplab.bsky.social · 17/06/2025We are accepting applications for a PhD opportunity at @scilifelab.se this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity. A EU funded generous fellowship is offered with possibility of industry experience. Apply here:thewittysquare.euPhD project in METABOLIC REGULATION OF GENOME FUNCTION AND CELL IDENTITY – Ilaria Piazza Laboratory 065
Reposted by Marc van OostrumZeynep Okur @zeynepokur.bsky.social · 11/06/2025@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...sciencedirect.comMolecular programs specifying properties and plasticity of parvalbumin interneuron innervationParvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat… 1137
Reposted by Marc van OostrumJulia Kuhl @somedonkey.bsky.social · 23/05/2025"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt... This one is for all the #ChandelierNeuron fans out there #sciArt #sciComm #neuroscience #neuroskyence 0182
Reposted by Marc van OostrumProteomes MDPI @proteomesmdpi.bsky.social · 22/05/2025🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025! 🎉Congratulations to all other prize winners! 👏 Warm congratulations to the organizers on the successful completion of the event! #proteomes #proteomics 021
Reposted by Marc van OostrumJoris de Wit @synapse-lab.bsky.social · 20/05/2025Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism. authors.elsevier.com/a/1l7HS5Sx5g... Work from Ben Verpoort and colleagues, with special thanks to our collaborators. 3347
Reposted by Marc van OostrumZampieri Lab @zampierilab.bsky.social · 13/05/2025We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction. www.biorxiv.org/content/10.1...biorxiv.orgThe glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam... 175
Reposted by Marc van OostrumNature Biotechnology @natbiotech.nature.com · 02/05/2025A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PMgo.nature.comA tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature BiotechnologyProtein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource. 23510
Reposted by Marc van OostrumETH Zurich @ethz.ch · 12/05/2025Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...ethz.chUnderstanding which proteins work togetherTeamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing... 12310
Reposted by Marc van OostrumPedro Beltrao @pedrobeltrao.bsky.social · 02/05/2025Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...nature.comA tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature BiotechnologyProtein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource. 313451
Reposted by Marc van OostrumMara Mueller @muellermara.bsky.social · 28/04/2025New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4 11610
Marc van Oostrum @marcvoo.bsky.social · 28/04/202550% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social ! www.biorxiv.org/content/10.1...biorxiv.orgThe proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulatorProteostasis - the maintenance of proteins at proper concentrations, conformations, and subcellular locations - is essential for cellular function and is governed by tightly regulated protein synthesi... 020
Reposted by Marc van OostrumPedro Beltrao @pedrobeltrao.bsky.social · 18/04/2025On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things. 0195
Marc van Oostrum @marcvoo.bsky.social · 17/04/2025Exciting paper - lots of things to discover in the data and the approach! 000
Reposted by Marc van OostrumSwiss National Science Foundation (SNSF) @snsf.ch · 11/04/2025❗Serious consequences for the Swiss economy and society – the SNSF urges the abandonment of the proposed cuts to research funding in "Relief Package 27," as they threaten the country's innovative capacity and competitiveness. ➡️buff.lyThe SNSF urges against cutsIn its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent. 02315
Reposted by Marc van OostrumSchweizerischer Nationalfonds - Fonds National Suisse @snf-fns.ch · 11/04/2025❗Gravierende Folgen für die Schweizer Wirtschaft und Gesellschaft: Der SNF fordert den Verzicht auf die im «Entlastungspaket 27» vorgesehenen Kürzungen bei der Forschungsförderung. Diese würden die Innovationskraft und Wettbewerbsfähigkeit des Landes gefährden. ➡️https://buff.ly/eorZPvlsnf.ch 173
Reposted by Marc van OostrumJoris de Wit @synapse-lab.bsky.social · 08/04/2025Postdoc opportunity in the heart of Europe! Check out the flyer below. Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits. 02118
Reposted by Marc van OostrumHovy Wong @hovywong.bsky.social · 04/02/2025My lab at CUHK (QS: 36th) is hiring! We are looking for motivated Research Assistants, PhD students (urgent🚨) and Postdocs who love solving problems. To understand the mysterious brain, we use a range of fun techniques. Please spread the word and get in touch if you are interested! 154
Reposted by Marc van OostrumJesperOlsenLab @jesperolsenlab.bsky.social · 31/03/2025🚀 Excited to share our latest article in #singlecell proteomics published in Cell! We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution! www.cell.com/cell/fulltex...eur02.safelinks.protection.outlook.comGlobal analysis of protein turnover dynamics in single cellsThe SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies. 24612
Reposted by Marc van OostrumBiozentrum, University of Basel @biozentrum.unibas.ch · 07/03/2025Flow Cytometry Operator/Specialist at the FACS Core Facility (FCF) of the Biozentrum, University of Basel (60-80%) www.biozentrum.unibas.ch/open-positio... @biozentrum @unibas.ch #Biozentrum #Basel #research #science #joboffer #hiring #cytometry #operator 018
Reposted by Marc van OostrumCarmen Sandi @carmensandi10.bsky.social · 05/03/2025Discover and follow the announcement of the Brain Prize 2025 winners today, March 5th, here: brainprize.orgbrainprize.orgThe Brain PrizeThe Brain Prize is the world’s largest prize for brain research that is awarded each year by the Lundbeck Foundation. 073
Marc van Oostrum @marcvoo.bsky.social · 03/03/2025Impressive & insightful study! Reminds me of this nice figure from Aebersold & @mannlab.bsky.social 2016 021
Marc van Oostrum @marcvoo.bsky.social · 21/02/2025Synapse-astrocyte proximities differ across synapse types! Exciting insights into synaptic diversity from the Helmstaedter lab at @mpibrain.bsky.social 000
Reposted by Marc van OostrumZampieri Lab @zampierilab.bsky.social · 28/01/2025We are very excited to share that the recent research from our lab has been published in Nature Biotechnology! Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research! www.nature.com/articles/s41...nature.comA human metabolic map of pharmacological perturbations reveals drug modes of action - Nature BiotechnologyMapping the metabolic effects of drugs helps define their mode of action. 1187
Reposted by Marc van OostrumFan Liu @fan-liu.bsky.social · 20/01/2025We have #postdoc openings in proteomics and structural+computational+cell biology. We offer cutting-edge infrastructure and an interdisciplinary engaging environment. Check out our ongoing research and recent papers at www.theliulab.com Interested? Message me here or at www.theliulab.com/contacttheliulab.comThe Liu LabThe Liu lab develops cross-linking and mass spectrometry methods to study protein structures and interactions in health and disease. 01512
Reposted by Marc van OostrumMax Planck Institute for Brain Research @mpibrain.bsky.social · 21/01/2025Congratulations to @mpibrain.bsky.social director Gilles Laurent for being awarded the 2025 Louis-Jeantet prize for Medicine! The @louisjeantetfdn.bsky.social recognizes Laurent's pioneering work on the operations of #neurons and dynamics of neuronal networks. More infos 👉 bit.ly/4hqk6iebrain.mpg.deGilles Laurent is awarded the Louis-Jeantet Prize for Medicine in 2025The 2025 Louis-Jeantet Prizes are awarded to Gilles Laurent, director at the Max Planck Institute for Brain Research in Frankfurt and to Veit Hornung, professor at the Ludwig Maximilian University of ... 16118
Marc van Oostrum @marcvoo.bsky.social · 25/12/2024Increased resolution for the discovery of newly synthesized cell-type specific proteomes in vivo! 071
Reposted by Marc van OostrumBiozentrum, University of Basel @biozentrum.unibas.ch · 23/12/2024Laboratory technician (50-100%) in synapse-type specific proteome studies www.biozentrum.unibas.ch/open-positio... @unibas.ch #Biozentrum #Basel #research #science #joboffer #scientific 032
Reposted by Marc van OostrumAnna Schroeder @annaschroeder.bsky.social · 16/12/2024Schroeder Lab website is now live! 🔥 Check it out 🤩 to learn about who we are, what we do to study how the brain gives rise to internal states that drive adaptive behavior 🧠, and how you can join the team 👇 🧪 Spread the word! www.annaschroederlab.comannaschroederlab.comSchroeder LabThe Schroeder Lab at the Ludwig Maximilian University of Munich explores how neural circuits transform internal drives such as hunger, emotion, and curiosity into action. 35011
Marc van Oostrum @marcvoo.bsky.social · 06/12/2024🎅 Excited to share our review in @natrevneurosci.bsky.social with @erin-schuman.bsky.social: “Understanding the Molecular Diversity of Synapses”🧠 Classification, importance of systems approaches, sources of diversity, and more! rdcu.be/d2xxF @snsf-ch.bsky.social @maxplanck.de @biozentrum.bsky.socialrdcu.beUnderstanding the molecular diversity of synapsesNature Reviews Neuroscience - The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular... 04414