Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg has shown promising results in early-phase trials; the efficacy of the ...

If you're trying to build muscle, getting enough protein is a must. But does it matter if that protein comes from meat or plants? A new study overturns assumptions.

This study uses data from the US nationwide electronic health record–based Epic Cosmos Dataset to examine prescriptions for semaglutide and tirzepatide, focusing on differences across race, ethnicity,...

In a randomized, crossover clinical trial in healthy young adults with varying weights, sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motiva...

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

This study compares the cost-effectiveness of 4 antiobesity medications (naltrexone-bupropion, phentermine-topiramate, semaglutide, or tirzepatide) with lifestyle modification vs lifestyle modificatio...

Jennifer A. Ligibel, MD, from the Dana-Farber Cancer Institute and Harvard Medical School, Boston, explains how obesity influences the risk of developing cancer and how it influences the prognosis of existing cancer.

lued dietary substrate. Recent findings SCFAs act systemically through stimulation of G protein receptors (GPRs) and inhibition of histone deacetylases (HDACs). SCFAs cause appetite suppression, re...

This secondary analysis of a target trial emulation of a comparative effectiveness study uses claims data to estimate the risk of incident thyroid cancer in adults with type 2 diabetes starting treatm...

Neuroscience; Microbiome

Semaglutide reduces albuminuria and the risk of kidney disease progression in patients with type 2 diabetes and chronic kidney disease (CKD). We conducted a randomized placebo-controlled double-blind ...

An atlas of the associations between the use of GLP-1 receptor agonists (GLP-1RAs) and 175 health outcomes reports the effectiveness and risks of GLP-1RAs compared with other antihyperglycemic medicat...

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

How did he get those photos? Doug Mills, senior photographer in Washington for The New York Times, tells the stories behind six of his most memorable pictures from the presidency of Joe Biden.

This cross-sectional study examines US trends in adult obesity prevalence from 2013 to 2023.

The use of incretin analogues has emerged in recent years as an effective approach to achieve both enhanced insulin secretion and weight loss in type 2 diabetes (T2D) patients. Agonists which bind and...

With the growing popularity of plant-based meat analogs (PBMAs), an investigation of their effects on health is warranted in an Asian population.This …

Abstract. While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeu

If you are short on time and space, here is a cheap, effective way to get stronger.

Our tech columnist visits a doctor assisted by AI. He finds potential and worrisome questions about whether it’s accurate, biased or always useful in health care.

Concerns persist regarding the cognitive safety of achieving very low levels of low-density lipoprotein (LDL) cholesterol. Although short-term studies are reassuring, the long-term cognitive effect...