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Nicole Treichel

@treichelnicole.bsky.social
46 followers 56 following 9 posts

Post doctoral researcher in the Clavel Lab at the RWTH University Hospital

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Reposted by Nicole Treichel
Joel Selkrig @jselkrig.bsky.social · 29/09/2026
How do gut bacteria cope with both proteolytic stress and phage attack? 🧵👇 Our latest preprint is live! Ulcerative colitis (UC) creates a distinct gut environment: protease activity rises, the virome shifts, and phages expand. #Microbiome #Bacteriophages #IBD www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Nicole Treichel
Thomas Clavel @tclavel.bsky.social · 25/06/2026
Excellent work by our one and only #CharliePauvert. We use it in all our high-throughput anaerobic cultivation projects. More to come... 💫
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Reposted by Nicole Treichel
Healthcare in Europe (DE) @health-europe-de.bsky.social · 24/04/2026
Das #Mikrobiom im #Darm hat großen Einfluss auf die #Gesundheit – doch wie zuverlässig lässt es sich bestimmen? Ein Team um @tclavel.bsky.social und @treichelnicole.bsky.social von der @rwth.bsky.social zeigt in einer neuen Studie, dass #Metagenomsequenzierung nicht immer das ganze Bild zeigt.
healthcare-in-europe.com
Studie: Mikrobiom-Analysen zeigen nicht immer das ganze Bild
Forscherinnen und Forscher der RWTH Aachen haben eine wichtige Methode zur Charakterisierung des Darmmikrobioms systematisch auf Potenzial und Grenzen geprüft. Ihre Ergebnisse ermöglichen Forschenden ...
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Reposted by Nicole Treichel
Thomas Clavel @tclavel.bsky.social · 21/04/2026
Strain diversity influences microbiome functions, and can be assessed with metagenome-assembled genomes (MAGs). But many MAGs are inaccurate! Benchmarking of shotgun sequencing by ⭐ @treichelnicole.bsky.social ⭐ with @nfdi4microbiota.bsky.social , in @natmicrobiol.nature.com 👉 rdcu.be/feAWc
rdcu.be
Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis
Nature Microbiology - A comparison of sequencing of complex mock communities performed at multiple depths and analysed using different methods establishes minimum standards that can ensure the...
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Segata Lab @cibiocm.bsky.social · 21/01/2026
🥁 NEW Our study on infant gut microbiome and #straintransmission is now published in @nature.com: doi.org/10.1038/s415... 1/10
doi.org
Baby-to-baby strain transmission shapes the developing gut microbiome - Nature
A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...
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Nicole Treichel @treichelnicole.bsky.social · 14/01/2026
I am happy to announce that the updated version of our manuscript "Benchmarking of shotgun sequencing depth highlights limitations of strain-level analysis and shallow metagenomics" is available on bioRxiv now. 🎉 www.biorxiv.org/content/10.1...
biorxiv.org
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Sebastian Schmidt @tsbschm.bsky.social · 23/09/2025
Fecal filtrate is less effective than donor stool (FMT) for the treatment of C. difficile recurrence. Now shown in a multicentre trial, out today in @lancetgastrohep.bsky.social . Congratulations to Dina Kao @ualberta.bsky.social & team! Gift link: authors.elsevier.com/c/1lphg8nByr...
authors.elsevier.com
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Thomas Clavel @tclavel.bsky.social · 18/09/2025
Interested in the design of defined microbial communities for fundamental research and applications? Hope this work & tool will help you 👇 As always @tcahitch.bsky.social has been a driving factor ⭐⭐⭐! github.com/ClavelLab/Mi...; academic.oup.com/ismej/advanc...
academic.oup.com
Validate User
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Segata Lab @cibiocm.bsky.social · 19/05/2025
There is still time to apply for #PhD studentships with us! Thanks for spreading the word. #phdchat #phdlife #academiclife
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Reposted by Nicole Treichel
Segata Lab @cibiocm.bsky.social · 16/05/2025
🥁 NEW: Commentary in @cellcellpress.bsky.social! by @msabrysarhan.bsky.social Giacomo Antonello @whansi.bsky.social @cengoni.bsky.social @dmascalzoni.bsky.social @leviwaldron1.bsky.social Nicola Segata, Christian Fuchsberger www.cell.com/cell/fulltex... 1/4
cell.com
Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...
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DECISION Horizon2020 @decision4liver.bsky.social · 09/05/2025
Next at the DECISION Networking Session at #EASL2025, Theresa Wirtz (UKA) presents scRNA-seq data showing a monocyte subset linked to ACLF risk. Fascinating translational science in action! @brunslab.bsky.social ky.social @easlnews.bsky.social ky.social #scRNAseq #ACLF
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Thomas Clavel @tclavel.bsky.social · 06/05/2025
Very happy that HiBC is out: rdcu.be/ekSCO 🔥 @natcomms.nature.com Excellent team spirit, and, as always, great driving factor by @tcahitch.bsky.social ⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀
rdcu.be
HiBC: a publicly available collection of bacterial strains isolated from the human gut
Nature Communications - Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All...
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EMBL Events @events.embl.org · 06/05/2025
📣 Explore cutting-edge breakthroughs in #microbiome research, from methodological innovations to integrative approaches and personalised therapeutics. Join #EESMicrobiome 🦠🔍 📅 16 – 19 Sep 2025 📍 EMBL Heidelberg and Virtual 📥 Submit your abstract by 24 June ➡️ s.embl.org/ees25-08-bl
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Thomas Clavel @tclavel.bsky.social · 29/04/2025
Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social
rdcu.be
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research
Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
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Tom Hitch @tcahitch.bsky.social · 04/04/2025
Ever wondered if we are correctly predicting proteins from metagenomes? If so, we are happy to present our new work improving the prediction of proteins from the human gut microbiome: www.nature.com/articles/s41...! We corrected how each taxon's proteins are predicted and found WAY more proteins!
nature.com
Lineage-specific microbial protein prediction enables large-scale exploration of protein ecology within the human gut - Nature Communications
Microbes within the gut vary in how they encode genes, both in terms of the genetic codes and gene structures, which are often unexplored in metagenomic analysis. Here, the authors develop a lineage-s...
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Joel Selkrig @jselkrig.bsky.social · 12/03/2025
📣 Conference Announcement! Till Strowig, @lisamaierlab.bsky.social and I have organized a stellar lineup of speakers from different corners of the Microbiome field for the 17th SeeOn Conference in picturesque Bavaria. Open to all! Abstracts due April 6th. Spread the news! www.dghm.org/seeon/
dghm.org
Seeon - Deutsche Gesellschaft für Hygiene und Mikrobiologie
Microbiota, Probiotics and Host    → Flyer 17th Seeon Conference Registration (click here for registration) The steering committee of the “Microbiota, Probiotics and Host”- group warmly invites you t...
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Reposted by Nicole Treichel
Tom Hitch @tcahitch.bsky.social · 28/03/2025
If you generate, or use MAGs, you should really read the work we have done benchmarking their limitations. Using complex mock communities (70 species), we assessed how deeply you need to sequence to accurately conduct common metaG analyses. Webwere shocked to see even HQ MAGs are often chimeric!
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