iiinova — where your digital self keeps evolving

Reposted by Michael Hanna

shawnferguson.bsky.social @shawnferguson.bsky.social · 22/04/2026

How do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes doi.org/10.1083/jcb....

doi.org

A pressure relief valve for lysosomes

Nassar and Ferguson discuss work from Kim et al. showing that TMEM63A protects lysosomes from rupture by acting as a pressure relief valve when membrane te

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Reposted by Michael Hanna

Vanni Lab at UNIFR, Switzerland @labvanni.bsky.social · 07/08/2025

Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social‬. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...

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Michael Hanna @mike-hanna.bsky.social · 07/11/2025

Fantastic new work revealing mechanisms of pro-apoptotic signaling as a result of lysosomal dysfunction and subsequent DNA damage.

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Reposted by Michael Hanna

Hely Rodriguez @helyrodriguez.bsky.social · 04/11/2025

In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.

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Michael Hanna @mike-hanna.bsky.social · 22/10/2025

The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊 You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽 Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...

psu.wd1.myworkdayjobs.com

Research Technologist

APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...

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Reposted by Michael Hanna

Yale Neuroscience @yaleneuro.bsky.social · 20/10/2025

Recent @yale.edu research led by ‪‪@adwolfe.bsky.social‬‬, Milind Singh & @dacolon.bsky.social reveals neurons' ability to store glycogen as a backup fuel ⛽️, keeping the brain running under stress — a process called “glycogen-dependent glycolytic plasticity” (GDGP).

news.yale.edu

Neurons use built-in ‘backup batteries’ that fuel the brain under stress

A new Yale study reveals that neurons store their own sugar reserves that kick in to keep the brain functioning during metabolic stress.

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Reposted by Michael Hanna

Luis Bonet-Ponce @lysoluis.bsky.social · 14/10/2025

🚨 We’re hiring a postdoc! 🚨 Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab! Reach out directly: luis.bonetponce@osumc.edu Learn more: bonetponcelab.com Let’s chat!

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Reposted by Michael Hanna

The Hanna lab @hanna-lab.bsky.social · 07/10/2025

The Hanna lab has a website! 🖥️ Come check it out to see what we’ll be up to 😁 sites.psu.edu/hannalab

sites.psu.edu

The Hanna Lab – Penn State Univeristy | Department of Biochemistry & Molecular Biology

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Reposted by Michael Hanna

Luis Bonet-Ponce @lysoluis.bsky.social · 24/09/2025

Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!

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Reposted by Michael Hanna

Journal of Cell Biology @jcb.org · 03/09/2025

@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...

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Reposted by Michael Hanna

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/08/2025

👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion! Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben! Check out the manual: bit.ly/46DuL6R

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Reposted by Michael Hanna

Jeff Jones, PhD @jrjones.bsky.social · 28/07/2025

Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊 #Neuro #Aging #Alzheimers #UF ufresearch.bsky.social‬

https://ufresearch.bsky.social‬

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Reposted by Michael Hanna

Melanie McReynolds @drohsopretty.bsky.social · 30/07/2025

In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator. Forever grateful to past and present members of my lab for helping me accomplish this dream.

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Reposted by Michael Hanna

Andrés Guillén Samander @aguillensamander.bsky.social · 26/07/2025

One for the Apicomplexa peeps: ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites. Happy+proud to share and keen to hear thoughts!

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Michael Hanna @mike-hanna.bsky.social · 24/06/2025

Check out this great new preprint by Sam Block et al. from @mvhlab.bsky.social @korylab.bsky.social uncovering how a range of neutral amino acids are transported in mitochondria www.biorxiv.org/content/10.1...

biorxiv.org

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Michael Hanna @mike-hanna.bsky.social · 28/05/2025

A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social

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