Reposted by Krishna MelnatturYichen Luo 骆奕辰 @camellyc.bsky.social · 03/08/20261/8 Breathing seems automatic. But it's a finely tuned motor behavior that has to be controlled. In this preprint, I map the circuits that match a fly's respiration to the metabolic demands of flight and mitigate the risk of dehydration. 🧵🪰 www.biorxiv.org/content/10.6... 411943
Reposted by Krishna MelnatturJohannes Felsenberg @felsenberg.bsky.social · 31/07/2026Finally out in @natneuro.nature.com! A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work! www.nature.com/articles/s41...nature.comCreating true and false memories from forgotten information in Drosophila - Nature NeuroscienceForgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in... 1214154
Krishna Melnattur @melnattur.bsky.social · 02/08/2026Come mothers and fathers throughout the land Don’t criticize what you can’t understand Your sons and your daughters are beyond your command Your old road is rapidly aging Get out of the new one if you can’t lend a hand For the times they are a changing m.thewire.in/article/poli...m.thewire.inIn Defence of the Profanity of Protesters - The WireThe state had a script for slogans, petitions, op-eds – the standard grammar of Indian dissent, which it had learned to out-shout, outspend or simply wait out over ten years in power. It had no script... 020
Krishna Melnattur @melnattur.bsky.social · 10/07/2026Sometimes authors have been a bit ornery about it though like ‘I’m not sure if I’m allowed to / if it’s legal to do this’… 100
Reposted by Krishna MelnatturMukund Thattai @thattai.bsky.social · 09/05/2026The origin story of eukaryotes has more plot twists than a Hollywood blockbuster! 🧵 Read more in my new review: doi.org/10.1146/annu.... Only in the 1960s were the terms "prokaryote" and "eukaryote" formalized! As originally defined, eukaryotes had complex architectures, prokaryotes did not. 78431
Reposted by Krishna MelnatturDeepa Rajan, PhD @deeparajan.bsky.social · 23/04/2026How can a single cell learn without a brain? We explore this in my paper with @wallaceucsf.bsky.social! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny! 426789
Reposted by Krishna MelnatturCarolina Rezaval @crezaval.bsky.social · 29/03/2026www.nature.com/articles/d41...nature.comDopamine takes a hit: how neuroscience is rethinking the ‘feel-good’ chemicalIt has long been known as the arbiter of reward in the brain, but recent findings could upend this classic theory of dopamine function. 081
Reposted by Krishna MelnatturKatrin Vogt @katrinvogt.bsky.social · 02/02/2026The first paper from the lab is now out in Science Advances: Multimodal social context modulates larval behavior in Drosophila www.science.org/doi/10.1126/... We find that fly larvae keep their distance to conspecifics in the absence of food, enjoy reading! @cbehav.bsky.social @uni-konstanz.de 68637
Krishna Melnattur @melnattur.bsky.social · 26/10/20252 legs, 4 legs 🤷 6 legs - now we're talking! 110
Reposted by Krishna MelnatturScott Waddell @scottishwaddell.bsky.social · 23/10/2025@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out. www.biorxiv.org/content/10.1...biorxiv.orgVisceral signaling of post-ingestive malaise directs memory updating in DrosophilaConsolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor... 14217
Reposted by Krishna MelnatturArthur Charpentier @freakonometrics.bsky.social · 22/10/2025"Universities have existed for more than a thousand years — and for almost all of that time, they weren’t centers of research. What changed in 19th century Germany?" asteriskmag.substack.com/p/the-origin...asteriskmag.substack.comThe Origin of the Research UniversityUniversities have existed for more than a thousand years — and for almost all of that time, they weren’t centers of research. What changed in 19th century Germany? 03013
Krishna Melnattur @melnattur.bsky.social · 07/10/2025Just seeing this, looks terrific even to my currently jet-lagged brain, congrats Abhilasha! 010
Krishna Melnattur @melnattur.bsky.social · 02/10/2025Thanks, Caro! I see you’re going to be at CSHL next week. Will be there too, look fwd! 010
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Thanks Mark! The mutants have been super helpful, thanks so much ! Re: axenic, yeah a student in Paul Shaw's lab at WashU had tried this experiment some years back when I was there, and didn't see anything for sleep then (in wild type flies). 020
Krishna Melnattur @melnattur.bsky.social · 01/10/2025More in the preprint – do check it out! Would love feedback. Didn’t think we would be doing classical neurogenetics tbh, but here we are! These genes are cool, lots to mine here (fini) 120
Krishna Melnattur @melnattur.bsky.social · 01/10/2025This expt I really like. We used @kayserlab.bsky.social’s sleep restriction protocol to enhance sleep behaviorally and saw improvements in memory! This comes straight from human psychology – cognitive behavioral therapy for insomnia (CBTI) amazing that it works in the fly! (12/n) 130
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Finally, we asked if the memory defects of some AMP mutants could be reversed by enhancing sleep. We find that enhancing sleep of Bomanin mutants using the GABA agonist Gaboxadol robustly increased sleep and improved memory (11/n) 110
Krishna Melnattur @melnattur.bsky.social · 01/10/2025So these ‘immune effectors’ seem to act in glia to modulate sleep and memory. Indeed expression profiling suggests that glial might express many AMPs – cool! (10/n) 120
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Group C are doubly mutant for the anti-fungal peptides Metchnikowin (mtk) and Drosomycin (Drs). We knocked down Mtk and Drs in different tissues and saw that glial knockdown mimicked the deletion mutants. (9/n). 110
Krishna Melnattur @melnattur.bsky.social · 01/10/2025The Group C mutants seem to be able to carry out (some) sleep functions sans much sleep. Very cool! But how do they do it? We first thought maybe the microbiome is messed up, so we eliminated the microbiome. And saw.. .. crickets (8/n) 110
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Sleep in strongly associated with learning and memory. We find that most AMP mutants are impaired in learning and memory using @alexckeene.bsky.social’s gustatory assay. Counter-intuitively Group C mutants that sleep the least uniquely retained normal learning and memory (7/n) 120
Krishna Melnattur @melnattur.bsky.social · 01/10/2025We next evaluated sleep functions. As per the synaptic homeostasis hypothesis, extended waking upscales synapses. The Group C mutants that slept the least surprisingly showed lower synapse abundance (6/n) 120
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Evaluating baseline sleep is ok, but sleep is also known to be plastic to environmental changes and ecological changes. We find that specific AMPs are required for context dep changes e.g. socialization and rocking induced sleep (5/n) 110
Krishna Melnattur @melnattur.bsky.social · 01/10/2025We next evaluated sleep homeostasis reasoning that low sleep might be a result of inability to generate needed sleep. Most mutants were unaffected, Group C mutants that sleep the least uniquely showed an exaggerated rebound. (4/n) 120
Krishna Melnattur @melnattur.bsky.social · 01/10/2025AMP mutants sleep less, with a longer latency i.e. they take longer to fall asleep. Sleep regulation by AMPs might be common (3/n) 110
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Sleep and immunity are linked. But just how deeply is unclear. Here we obtained mutants in different antimicrobial peptides (AMPs), effectors of fly innate immunity, and characterized their roles in sleep and plasticity (2/n) 110
Krishna Melnattur @melnattur.bsky.social · 01/10/2025Happy to share our lab’s first preprint! ‘Mutations in antimicrobial peptides differently affect sleep and plasticity’. Led by @rahulkumar211.bsky.social, with help from many in the lab. In collaboration with @evoimmunoimroze A thread 1/n www.biorxiv.org/content/10.1...biorxiv.orgMutations in antimicrobial peptides differently affect sleep and plasticityMolecules implicated in host defense can, independent of their roles as immune mediators, regulate sleep. In mammals, cytokines such as Tumor Necrosis Factor α (TNF α) and Interleukin 1β (IL1 β) promo... 3184
Reposted by Krishna MelnatturAndré Nadler @nadlerlab.bsky.social · 21/08/2025Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41... 31346130
Reposted by Krishna MelnatturOmer Sharon @omersharon.bsky.social · 23/08/2025Fresh results now in bioRxiv! 🎉 We know about the function of NREM sleep for overnight memory consolidation. But what about REM sleep? We found that in aging, slow delta waves can intrude phasic REM periods, and this, is associated with worse overnight consolidation 🧠 (1/5) doi.org/10.1101/2025...doi.orgREM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in AgingRapid Eye Movement (REM) sleep degrades with age, and more severely in Alzheimer's disease (AD). REM sleep comprises about twenty percent of adult sleep, alternates between phasic and tonic periods, a... 12513
Reposted by Krishna MelnatturAbhilasha Joshi, PhD @rhythmicspikes.bsky.social · 25/08/2025We are still accepting applications for the #postdoc opportunity in the lab 🕵♀️ 🧠 More details 👇 Postdoctoral position: lnkd.in/g4TkRxpM Research directions: lnkd.in/eV2iMKGf Our team and philosophy: lnkd.in/eh3nnNgq ⏬lnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn 21311
Reposted by Krishna MelnatturIda Momennejad @neuroai.bsky.social · 18/08/2025"The aim of science is not to open the door to infinite wisdom but to set a limit to infinite error.” - Bertolt Brecht The Life of Galileo 0252
Reposted by Krishna MelnatturPiali Sengupta @senguptalab.bsky.social · 15/08/2025More new science from the lab! Led by @nathancsharris.bsky.social (now at GA State) and PD Priya Dutta. We describe how experience tunes the ratios of functional receptors in a single sensory neuron via coordinating transcriptional and post-transcriptional mechanisms to drive response plasticity. 44720
Krishna Melnattur @melnattur.bsky.social · 01/08/2025Thanks for making it out, Anya! We loved hosting, it was a fun meeting! 000
Krishna Melnattur @melnattur.bsky.social · 30/07/2025This effort to write up the Meeting Review was led entirely by PhD students! Couldn’t be happier for you all! Hope you all go on to great things! @rahulkumar211.bsky.social @ritikamukherji.bsky.social Kamakshi Singh @embo.org @biologists.bsky.social 020
Krishna Melnattur @melnattur.bsky.social · 30/07/2025Happy to share a wonderful Meeting Review of our @sleepneuroscience.bsky.social meeting in March! #EMBONeuroSleep shorturl.at/bFxPlshorturl.atReflections on the EMBO Workshop: Neuroscience of Sleep 2025Summary: The inaugural EMBO workshop on the neuroscience of sleep brought together a global sleep research community to discuss recent advances across species, scales and systems. The meeting explored... 161
Reposted by Krishna MelnatturAndrew Coogan @cooganlab.bsky.social · 15/06/2025Sleep disturbance as the strongest predictor of subsequent psychiatric disorders in young people (greater than family history and adverse childhood experiences). Sleep disturbance is modifiable, a key node for intervention. www.nature.com/articles/s41...nature.comPrediction of mental health risk in adolescents - Nature MedicineUsing longitudinal survey and neuroimaging data from more than 11,000 adolescents in the United States, a machine learning model shows promising performance in identifying individuals at greater risk ... 085
Krishna Melnattur @melnattur.bsky.social · 29/05/2025Agree 100%. A lot of students think of science as a hit parade, and don’t like sweating the small stuff. But the small stuff matters 010
Krishna Melnattur @melnattur.bsky.social · 21/04/2025Interesting read from the Seelig labnature.comDynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila - Nature NeuroscienceAnimals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with... 041
Krishna Melnattur @melnattur.bsky.social · 17/03/2025Thoughtful discussions, and an all round whale of a time! Lovely to celebrate 25 years of sleep in flies with our fields founders - Paul Shaw and Amita Sehgal. Thanks to everybody that made it out 021
Krishna Melnattur @melnattur.bsky.social · 17/03/2025And, it's a wrap! 3 wonderful days after a year in planning for the EMBO Workshop Neuroscience of Sleep @sleepneuroscience.bsky.social . 141
Reposted by Krishna MelnatturHorst Obenhaus @octoscience.bsky.social · 16/03/2025Amazing time indeed. Thank you so much, everybody, and @melnattur.bsky.social particularly! 🐙 183
Reposted by Krishna MelnatturAlice French @aliceisnotfren1.bsky.social · 14/03/2025Had a really amazing time @sleepneuroscience.bsky.social at Neuroscience of sleep conference in Delhi. Thought provoking science and fabulous company. Thankyou @melnattur.bsky.social and other organisers. 153
Krishna Melnattur @melnattur.bsky.social · 14/03/2025Thanks for coming Alice, and bringing your crew! It was fun hanging out! Hope to meet again soon! 010
Reposted by Krishna MelnatturNeuroscience of Sleep @sleepneuroscience.bsky.social · 09/03/2025🎉🛍️ Exciting news! The EMBO workshop- Neuroscience of Sleep 2025 kit is here. It includes a T-shirt, tote bag, notebook, and pencil. We hope all the attendees are ready to dive into the latest in sleep research 🧠💤. Get ready to learn, connect, and take notes in style! ✨ #EMBOneuroSleep 023