Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in...

The state had a script for slogans, petitions, op-eds – the standard grammar of Indian dissent, which it had learned to out-shout, outspend or simply wait out over ten years in power. It had no script...

It has long been known as the arbiter of reward in the brain, but recent findings could upend this classic theory of dopamine function.

Consolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor...

Universities have existed for more than a thousand years — and for almost all of that time, they weren’t centers of research. What changed in 19th century Germany?

Molecules implicated in host defense can, independent of their roles as immune mediators, regulate sleep. In mammals, cytokines such as Tumor Necrosis Factor α (TNF α) and Interleukin 1β (IL1 β) promo...

Rapid Eye Movement (REM) sleep degrades with age, and more severely in Alzheimer's disease (AD). REM sleep comprises about twenty percent of adult sleep, alternates between phasic and tonic periods, a...

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Summary: The inaugural EMBO workshop on the neuroscience of sleep brought together a global sleep research community to discuss recent advances across species, scales and systems. The meeting explored...

Using longitudinal survey and neuroimaging data from more than 11,000 adolescents in the United States, a machine learning model shows promising performance in identifying individuals at greater risk ...

Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with...

Two parasitoid wasp venom proteins induce imaginal disc degradation of its host fly Drosophila larva, ensuring parasitism success.

Maguire, mastermind of the famous London taxi-driver study, broadened the field and championed the importance of spatial representations in memory.

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

Sleep science is at an exciting juncture. The realization that sleep is near universal among animals has revolutionized the field. The ubiquity of sleep extends to the discovery of different sleep st…

How are positive and negative experiences integrated during learning? Here, Molina-García, Colinas-Fischer, et al. find that the neuropeptide PDF-1 encodes both experiences by being released from and ...

Artificial intelligence and human expertise meet to generate a map of all the connections in the fly brain. The resource is already being used by experimentalists and theoreticians to further our unde...