ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-like states and markedly enhances antiviral and antitumour immunity.

Analyses of population cohorts found that young adults exhibited earlier systemic and organ-specific aging, which was associated with increased risk of early-onset cancer compared with older adults born decades earlier.

Nature Reviews Immunology, Published online: 23 April 2026; doi:10.1038/s41577-026-01291-5What is unique about the immune system of people who live to extreme old age? Here the authors describe that centenarians may achieve such longevity through several mechanisms, including limiting the pathological effects of inflammageing and immunosenescence, preservation of immune surveillance, sustained gut microbial diversity and maintenance of intestinal barrier integrity.

Objective Pain is the hallmark symptom of osteoarthritis (OA), and its biologic drivers remain poorly understood. Although the role of innate immunity in OA has been extensively studied, the involve...

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

Nature Reviews Rheumatology, Published online: 07 January 2026; doi:10.1038/s41584-025-01350-6A large European cohort clarifies COPA syndrome as a multi-organ interferonopathy defined by STING-driven interstitial lung disease (ILD). These findings refine diagnosis and treatment and establish COPA syndrome as a model for systemic autoimmune rheumatic disease-associated ILD.

This Medical News article is in remembrance of Atul Butte, MD, PhD, a pioneer in using data science to improve health.

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

The aim of this systematic literature review was to provide a comprehensive overview of T-Cell Receptor (TCR) mediated immunity research in osteoarthritis (OA).

Atul Butte, who championed the use of big data in science and health care and inspired a generation of trainees at UC San Francisco and beyond to pursue the fields he pioneered — translational and cli...

In this Review article, the potential of cytometry- and single-cell RNA sequencing-based immune profiling for aiding the diagnosis and personalized treatment of rheumatic diseases is discussed.

Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.

Osteoarthritis (OA) is now understood as a heterogeneous disease in many respects, including its clinical presentation, underlying pathophysiological mechanisms, and response to treatments. Distinct p...

Researcher and campus leader Atul Butte, MD, PhD, has been recognized for his outstanding career in the computational and health sciences with induction into the American Academy of Arts and Sciences,...

To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).

Nature Reviews Rheumatology, Published online: 07 February 2025; doi:10.1038/s41584-025-01218-9Garrido-Mesa and Brown review findings from TCR profiling studies in rheumatic diseases and discuss how improved study design might help elicit information…