The cartilage-bone interface, including the zone of calcified cartilage (ZCC), is a thin layer of calcified tissue with a low cell number, thus making…

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Erosive hand osteoarthritis (ErHOA) is a severe form of HOA associated with greater inflammation and disability. We aimed to explore its association with bone loss and fracture.

Greater body weight and body mass index (BMI) are associated with worse clinical outcomes in knee osteoarthritis, but these anthropometric measures do not assess fat mass. We evaluated sex-specific re...

Thumb carpometacarpal (CMC) osteoarthritis (OA) is multifactorial and may involve anatomical variability, altered biomechanics, joint laxity and impaired proprioception. We hypothesized that variabili...

Kashin-Beck disease (KBD) primarily impairs the epiphyseal plate in children and adolescents, resulting in enlarged bone ends and short stature. Given the abundance of type H vessels in the growing ep...

To investigate the effects of a matrikine, fibronectin fragment (FN7–10), on human osteoarthritic (OA) synovial fibroblasts and implications for inflammation and cartilage degradation.

Synovial fibrosis, characterized by mechanoactivation of fibroblast-like synoviocytes (FLS), is thought to be a driver of osteoarthritis (OA). Fibroblast activation protein (FAP) is expressed by activ...

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Intervertebral disc (IVD) degeneration (IVDD) is a prevalent contributor to low back pain, yet IVDD-modifying therapeutics are unavailable. Osteoporosis drug raloxifene reduces age- and sex-related IV...

Impaired subchondral bone perfusion contributes to bone marrow lesions (BMLs) in knee osteoarthritis (KOA); however, it has been assessed only under static and non-weight-bearing conditions. Dynamic, ...

Multiple epiphyseal dysplasia (MED), caused by mutations in MATN3, is a chondrodysplasia affecting the cartilage growth plate and is characterised by delayed epiphyseal ossification, short stature, an...

Alterations in cartilage mechanical properties may signal early degenerative changes preceding clinical or radiographic evidence of osteoarthritis. MRI-based techniques may detect these early pre-oste...

The long intergenic non-coding RNA Linc01152 is a recently identified lncRNA whose functional involvement in osteoarthritis (OA) remains largely understood. In the present study, we tried to elucidate...

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Even after intra-articular injections, therapeutics to treat osteoarthritis are limited by rapid drug clearance given their poor joint retention. To address this, we engineered a cationic Interleukin-...

Postmenopausal women exhibit a higher incidence of osteoarthritis (OA) than age-matched men. This study aimed to investigate the effects of osteoclasts under estrogen deficiency on chondrocytes and to...

Anterior cruciate ligament (ACL) injury initiates post-traumatic osteoarthritis (PTOA) via two distinct processes: initial direct contact injury of the cartilage surface during ACL injury, and seconda...

Osteoarthritis (OA) often coexists with metabolic traits (MTs), causing significant disability. Our study aims to uncover the shared genetic mechanisms between OA and MTs, revealing novel OA-MT relate...