El hallazgo abre nuevas vías para tratar alteraciones inmunitarias relacionadas con la edad mediante terapias ya disponibles

Un estudio liderado por el grupo de María Mittelbrunn en el Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) ha identificado uno de los mecanismos que alteran la producción de células […]

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Hepatic inflammation and immunosurveillance play major roles in the progression of liver cancer. A common trigger for hepatic inflammation is oxidative stress, which stems from mitochondrial dysfuncti...

The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction of T cells could disturb host–microbiota symbiosis and the physical integrity of the intestinal barrier, ultimately driving inflammageing and poor health outcomes. Finally, we propose microbiota- and T cell-based therapeutic interventions aimed at strengthening the intestinal barrier to promote healthier longevity. Namely, we discuss the transplantation of youthful microbiota, the use of designed probiotics, and the adoptive transfer of competent or engineered T cells.

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in associatio...

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in associatio...

Un estudio en ratones del Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM) revela que el mal funcionamiento de las mitocondrias —las estructuras celulares encargadas de producir energía— alte...

PPARγ downregulation in colonic CD8+ T cells from people with HIV (PWH) on antiretroviral therapy (ART) disrupts lipid metabolism and promotes contact-dependent epithelial apoptosis, leading to intest...

Nature Aging - T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate...

La pérdida de función de los linfocitos T CD4 altera la microbiota intestinal y, en consecuencia, acelera el envejecimiento celular y aumenta el riesgo de enfermedades múltiples. Es lo que […]

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.