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Mark Cookson

@markrcookson.bsky.social
354 followers 417 following 28 posts

Cell Biologist accidentally thinking about human genetics. He/him. Husband, Dad, wannabe musician and cook, immigrant. Views very definitely my own.

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Reposted by Mark Cookson
Molecular Neurodegeneration @molneurodegen.bsky.social · 18/03/2026
Inflammatory signaling differentially changes #chromatin accessibility and #gene expression of the PD-associated kinase #LRRK2 between human and mice Alexandra Beilina, Jae-Hyeon Park, Natalie Landeck...Mark R. Cookson @markrcookson.bsky.social #Parkinsons link.springer.com/article/10.1...
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Rockefeller University Press @rupress.org · 24/09/2025
In @jcb.org, @lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
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Mark Cookson @markrcookson.bsky.social · 24/04/2025
I heard Norway is recruiting “top” researchers to leave some countries and join them. Yet I have not had a call. Hallo?
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Reposted by Mark Cookson
James Myall @jamesxmyall.bsky.social · 27/02/2025
This is a sign of how upside down the constitutional order is right now. The President is supposed to ask Congress for money, not the other way around! #mepolitics
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Reposted by Mark Cookson
Kara Marshall @karalmarshall.bsky.social · 27/02/2025
I don't really have words for how devastating it would be to lose the entire intramural program. This has to be stopped.
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John Ball @john-m-ball.bsky.social · 27/02/2025
Just astonishing.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 27/02/2025
"Memoli had no choice, he insisted: He was following the direction of three HHS officials—Dorothy Fink, then the acting secretary; Heather Flick Melanson, chief of staff; and Hannah Anderson, deputy chief of staff of policy—who told him, in no uncertain terms, that the pause was to continue..." /1
theatlantic.com
Inside the Collapse at the NIH
Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Reposted by Mark Cookson
Danielle Beckman @daniellebeckman.bsky.social · 28/02/2025
The future of science in the U.S. is looking so promising.
In a not-so-dystopian future, glum-looking Oompa Loompas working at a sad Willy's Chocolate Laboratory will be the picture of science being made in the U.S.. .. Sad just like the experience in Glasgow.
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Reposted by Mark Cookson
Alzheimer's Association @alzassociation.bsky.social · 26/02/2025
Ensure the voices of people living with dementia and their caregivers are heard. Urge your members of Congress to reaffirm their commitment to the Alzheimer’s community today. We’ve made great progress and we cannot afford to stop now. bit.ly/alzaction
Now is the moment to do more, not less, in the fight against Alzheimer's. (Alzheimer's Impact Movement logo)
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Reposted by Mark Cookson
Kitty Murphy @kittybmurphy.bsky.social · 22/02/2025
I was part of the Marzi lab for my masters, PhD, and now postdoc. @sj-marzi.bsky.social is an enthusiastic scientist and supportive mentor. The science is cool and the people are even cooler. Can’t recommend enough!!! 🤓 Apply apply apply 👇🏻
my.corehr.com
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Mark Cookson @markrcookson.bsky.social · 02/12/2024
What fresh hell is this? Have a tea bag of reasonable repute in my hotel room but it’s decaffeinated? What use will this be tomorrow am???
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Reposted by Mark Cookson
Michael Ward @michael-e-ward.bsky.social · 28/11/2024
www.nature.com/articles/s41...
nature.com
Ångström-resolution fluorescence microscopy - Nature
The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off...
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Reposted by Mark Cookson
Tara C. Smith @aetiology.bsky.social · 27/11/2024
A two-month-old has died from pertussis in Queensland, Australia. Like many countries including the US, Australia is in the midst of a pertussis epidemic. In Queensland, uptake of maternal pertussis vaccination & infant vaccinations have declined. Lower rates of both put the youngest at risk.
theguardian.com
Infant dies amid worst Queensland whooping cough epidemic on record
Queensland Health confirms child’s death from highly contagious infection as vaccination rates plummet and cases spike across Australia
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Mark Cookson @markrcookson.bsky.social · 27/11/2024
useful rubric for those of us who love logic from @michelerosenthal.com Just in case this comes in handy in the next, say, few years or so
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Mark Cookson @markrcookson.bsky.social · 26/11/2024
Hey @mahoneykc.bsky.social more evolutionary information for you
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Reposted by Mark Cookson
Juan S. Bonifacino @juanbonifacino.bsky.social · 26/11/2024
In remembrance of those lost to COVID-19, I created a Spotify playlist featuring songs by musicians who passed away from the disease: open.spotify.com/playlist/6jE.... So much beautiful humanity gone.
open.spotify.com
Musicians lost to COVID-19
Playlist · jbonifacino1 · 23 items
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Mark Cookson @markrcookson.bsky.social · 19/11/2024
Patrick Stewart on behalf of many other old white men
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Reposted by Mark Cookson
Mychael Lourenco @mvlourenco.bsky.social · 19/11/2024
Interesting story!
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Mark Cookson
Patrick Lewis @patrickalfrynlewis.bsky.social · 19/11/2024
Interested in lysosomes? Fully funded iCASE PhD studentship available between me at RVC, Emily Eden at UCL, and Andreas Dannhorn at AstraZeneca. Details below… www.findaphd.com/phds/project...
findaphd.com
Integrated analysis of chemical induced lysosomal cytotoxicity at Royal Veterinary College on FindAPhD.com
PhD Project - Integrated analysis of chemical induced lysosomal cytotoxicity at Royal Veterinary College, listed on FindAPhD.com
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Reposted by Mark Cookson
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 18/11/2024
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease www.biorxiv.org/content/10.1101/202…
biorxiv.org
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Al
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Reposted by Mark Cookson
Mark Cookson @markrcookson.bsky.social · 18/11/2024
I've finally found out why I am stretched to capacity all the time. I've been saying NO to people for years but Americans need that translating
A book explaining how British people say No without saying NO
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Mark Cookson @markrcookson.bsky.social · 18/11/2024
Hey @meganduffyphd.bsky.social, need some postage stamps? www.theguardian.com/us-news/2024...
theguardian.com
US Postal Service honors Betty White with new postage stamp
Golden Girls actor appears on illustrated stamp that exudes her ‘spritely sense of fun’ for 2025 release
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Mark Cookson @markrcookson.bsky.social · 18/11/2024
I've finally found out why I am stretched to capacity all the time. I've been saying NO to people for years but Americans need that translating
A book explaining how British people say No without saying NO
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Reposted by Mark Cookson
adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Shannon Macauley @macauleylab.bsky.social · 16/11/2024
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia www.embopress.org/doi/full/10....
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Richard Sever @richardsever.bsky.social · 14/11/2024
Clarivate will strip eLife of its Impact Factor They never wanted one but will be interesting to see how this affects submissions given academia's obsession with it. retractionwatch.com/2024/11/13/e... But 1/2
retractionwatch.com
eLife won’t get an impact factor, says Clarivate
Clarivate, the data company for scholarly publications, has decided to continue indexing some content from eLife in Web of Science, after reevaluating the open-access biology journal’s unusual prac…
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Mark Cookson @markrcookson.bsky.social · 15/11/2024
In a talk about rational design of vaccines from structural biology. Vaccines are great.
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Selina Wray @selinawray.bsky.social · 15/11/2024
Very happy to share our paper on Familial British Dementia (FBD) which is online today! Using patient iPSC,we show the amyloidogenic peptide in this disease -ABri -is mainly produced by microglia… Never heard of FBD? You won’t be the only one… explainer incoming! link.springer.com/article/10.1...
link.springer.com
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...
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Mark Cookson @markrcookson.bsky.social · 13/11/2024
May as well start out with our big resource. We spent a long time getting this up and running - and it's now a real thing and still growing! Repost!!! www.jax.org/jax-mice-and...
jax.org
Human <span>iPS</span> Cells
In partnership with the iPSC Neurodegenerative Disease Initiative, a project from the Center for Alzheimer’s and Related Dementias (NIH), and with support from the Chan Zuckerberg Initiative, and Alig...
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