Reposted by Manvendra SinghMaya Voichek @mayavoichek.bsky.social · 24/09/2026Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7) 20257148
Reposted by Manvendra SinghbioRxiv Neuroscience @biorxiv-neursci.bsky.social · 05/09/2026A single-nucleus regulatory atlas links transposable elements to adult hippocampal neurogenesis www.biorxiv.org/content/10.64898/20… 022
Manvendra Singh @manusingh.bsky.social · 28/09/20268/8 Huge credit to first author @cakirumut.bsky.social for driving this work, and to @mfederica.bsky.social and @souad-youjilabadi.bsky.social from #RETROGEN Lab @inem-necker.bsky.social @institutimagine.bsky.social @cnrs.fr & our collaborators at UCLA and MPI. Preprint: doi.org/10.64898/202... 020
Manvendra Singh @manusingh.bsky.social · 28/09/20267/8 Together, the atlas maps where a pro-neurogenic signal reshapes chromatin and points to TE-derived sequences as possible parts of the regulatory network. We hope this cell-type-resolved resource helps others explore the adult hippocampus. 110
Manvendra Singh @manusingh.bsky.social · 28/09/20266/8 Several TE families were bound by neurogenic transcription factors. Their nearby genes are linked to neuronal differentiation and synapse formation. We propose these TE-derived sequences as candidate regulatory elements—not yet proven causal switches. 110
Manvendra Singh @manusingh.bsky.social · 28/09/20265/8 Here’s the striking TE result: transposable elements overlapped ~20% of candidate regulatory regions at baseline, but ~50% of regions that gained accessibility after rhEPO. Ancient mobile DNA was strongly enriched in the response. 110
Manvendra Singh @manusingh.bsky.social · 28/09/20264/8 The response was highly uneven: more than half of 39,404 regions with altered accessibility were in pyramidal neurons. Within that lineage, chromatin remodelling was strongest in newly formed neurons, rather than mature ones. 110
Manvendra Singh @manusingh.bsky.social · 28/09/20263/8 We profiled ~35,000 hippocampal nuclei with snATAC-seq and integrated the data with ~120,000 matched snRNA-seq nuclei. This gave us a cell-type-resolved view of chromatin accessibility across 11 major hippocampal lineages. 110
Manvendra Singh @manusingh.bsky.social · 28/09/20262/8 Adult hippocampal neurogenesis can respond to external signals. We used recombinant human erythropoietin (rhEPO) as a defined pro-neurogenic stimulus and asked: which cells change their chromatin, and could transposable elements be part of that response? 110
Manvendra Singh @manusingh.bsky.social · 28/09/20261/8 Proud and super thrilled to share our preprint, “A single-nucleus regulatory atlas links transposons to adult hippocampal neurogenesis.”, led by Umut, Fede, and Souad, the FIRST from our #RETROGEN lab @inem-necker.bsky.social . www.biorxiv.org/content/10.6... shrt thread on what we found 🧵 2139
Manvendra Singh @manusingh.bsky.social · 26/08/2026A Planet of Viruses. 🦠🌍 Scary but had a lot of fun talking about viruses today. They are everywhere, they have been with us forever, and they have even become part of our own genome. I have a feeling we’ll be talking a lot more about them in the years ahead. 😄 #Virology #HERVs #Genomics #Scienc 241
Manvendra Singh @manusingh.bsky.social · 25/07/2026What happened in India today teaches us a valuable lesson - To learn something new, one has to break their arrogance and pride, and Genz taught this #CJP 010
Reposted by Manvendra SinghEuropean Research Council (ERC) @erc.europa.eu · 23/07/2026🟠 Now open: ERC Starting Grant 2027 call for proposals! 🗓️ Deadline: 14 Oct 2026 📄 Call details: link.europa.eu/RwNMpX Planning to apply? Let our ERC Classes videos guide you through the application evaluation process. 👉 t.co/qGPy7Y8UhS #ERCStG #FrontierResearch @scienceinnovation.ec.europa.eu 03018
Reposted by Manvendra SinghRebecca Berrens @rberrens.bsky.social · 10/07/2026Hi #TEsky, please remember that we have an amazing community in the TransposonsWorldWide slack channel (join.slack.com/t/transposon...), which I encourage you to join. Another great resource is tehub.org. Please share !join.slack.comJoin TransposonsWorldwide on SlackSlack is a new way to communicate with your team. It’s faster, better organized, and more secure than email. 13622
Manvendra Singh @manusingh.bsky.social · 10/07/2026Proud moment for the RetroGen Lab! 🎉 Congratulations to Federica Mantovani on her selection for an oral presentation at the CNET meeting in Montpellier—a well-deserved recognition of her hard work and a fantastic opportunity to represent our lab. Bravo! 👏 #ProudPI 011
Manvendra Singh @manusingh.bsky.social · 15/06/2026Three Species in One House is Endless Entertainment One delegate refuses to acknowledge the other. The other delegate is desperately trying to make friends. And I’m the confused moderator wondering why nobody is speaking the same language. 010
Manvendra Singh @manusingh.bsky.social · 05/06/2026📍5 minutes before journal club. Today’s paper was… let’s say, not exactly light one of our PhD students sat down at the piano and played to calm everyone’s neurons before we wrestled with the paper. 🎹📖 Lucky to work with them. #AcademicLife #PhDLife #JournalClub #Science #ResearchLife #LabLife 020
Reposted by Manvendra SinghManvendra Singh @manusingh.bsky.social · 16/04/2026🔥Feeling so thrilled to see a story of our recent paper on Transposons and Preeclampsia on the front page of Femina Magazine. #TEsky www.femina.fr/article/gros...femina.frGrossesse : une nouvelle piste pour détecter la pré-éclampsie plus tôtEncore difficile à anticiper, la pré-éclampsie reste une complication redoutée de la grossesse. Mais une récente avancée scientifique, menée notamment par l’Institut Imagine, ouvre la voie à un dépist... 021
Reposted by Manvendra SinghCedric Feschotte @cedricfeschotte.bsky.social · 07/05/2026👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp... 15838
Reposted by Manvendra SinghInstitut Imagine @institutimagine.bsky.social · 05/05/2026🔬 What if we could spot preeclampsia before symptoms appear? Research by @manusingh.bsky.social in Genome Biology shows ancient viral remnants in our DNA act as "molecular switches" for placental development—leaving traces in maternal blood when they malfunction. 🎥 www.linkedin.com/feed/update/...linkedin.com#research #preeclampsia #genomics #medicalresearch #institutimagine | Institut Imagine🔬 What if we could detect preeclampsia before the first symptoms even appear? That is the promise of new research led by Dr. Manvendra Singh, group leader at INEM - Institut Necker Enfants Malades, i... 063
Manvendra Singh @manusingh.bsky.social · 16/04/2026🔥Feeling so thrilled to see a story of our recent paper on Transposons and Preeclampsia on the front page of Femina Magazine. #TEsky www.femina.fr/article/gros...femina.frGrossesse : une nouvelle piste pour détecter la pré-éclampsie plus tôtEncore difficile à anticiper, la pré-éclampsie reste une complication redoutée de la grossesse. Mais une récente avancée scientifique, menée notamment par l’Institut Imagine, ouvre la voie à un dépist... 021
Reposted by Manvendra SinghInstitut Imagine @institutimagine.bsky.social · 09/04/2026🧬 We are LIVE at the weekly MAGIC seminar at Imagine! Kicking us off is @joshwaterfall.bsky.social (@institutcurie.bsky.social ) presenting "Improved Out of Distribution Embeddings with AutoEncoders." Fascinating insights into computational biology! 🧵 163
Reposted by Manvendra SinghInstitut Imagine @institutimagine.bsky.social · 09/04/2026🧫 Wrapping up today's fantastic MAGIC seminar is @manusingh.bsky.social (@inem-necker.bsky.social). His talk: "Single-Cell Mapping of the Reawakening of Ancient Foes in Ageing Disorders." A deep dive into the molecular & cellular mechanisms of Alzheimer. Thanks to all speakers & see you next week! 🧪 053
Reposted by Manvendra SinghDr. Tyler A. Elliott @transposableman.bsky.social · 17/03/2026#TEsky Another paper in our TE ecology exploration of the Octopus out in BioEssays. Types of niches for TEs and what that could mean for their expression in neural tissue doi.org/10.1002/bies...doi.orgTransposon Ecology and the Octopus GenomeTransposable elements (TEs) are mobile strands of DNA prevalent in octopus genomes. TE activity in the octopus brain might reflect an organism-beneficial role in cognition; or could be a deleterious ... 2136
Reposted by Manvendra SinghAlessandro Prigione @aleprigio.bsky.social · 11/03/2026Our collaborative work is out now in CELL @cellpress.bsky.social We sugggest sildenafil as a repurposable drug for mitochondrial disease. A clinical trial is planned to start later this year. Thanks to collaborators, funders, and patient organizations! www.sciencedirect.com/science/arti...sciencedirect.comPluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapyMitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leig… 53710
Manvendra Singh @manusingh.bsky.social · 12/03/2026Ancient viral DNA drives preeclampsia in pregnancy | Max Delbrück Center www.mdc-berlin.de/news/news/an...mdc-berlin.deAncient viral DNA drives preeclampsia in pregnancyResearchers have uncovered the molecular details of how ancient viral DNA controls a gene linked to preeclampsia. The study, published in “Genome Biology,” builds on previous research and may lead to a diagnostic test to identify preeclampsia risk much earlier. 012
Manvendra Singh @manusingh.bsky.social · 08/03/2026Happy Women’s Day 🎊🎊😊to all of us and especially three outstanding women leading science at the highest level around our Necker Campus. Fabiola, Bana, and Yasmine, the directors of Necker, IMAGINE and Pasteur Institutes, respectively. Proud to be part of this cluster. 010
Manvendra Singh @manusingh.bsky.social · 08/03/2026Except the Jasprit Bumrah. He found a paradise even on this dead pitch :) 110
Manvendra Singh @manusingh.bsky.social · 05/03/2026Happy Holi everyone 🌈 A festival where poetry meets science as every color carries meaning, every wavelength shapes how we see the world. Train your eyes with colors and your heart with kindness. May peace, harmony, and love spread across every spectrum of humanity. 020
Manvendra Singh @manusingh.bsky.social · 03/03/2026In a mouse model of Primrose syndrome, rhEPO reverses. This is preclinical & could be the first tangible therapeutic path. Huge thanks to Justus, @cakirumut.bsky.social , Klaus and Hannelore and to an amazing team. DOI: 10.1172/jci.insight.200021 #RareDisease #Neurobiology #TranslationalResearch 010
Manvendra Singh @manusingh.bsky.social · 02/03/2026Stranded due to airspace closures. Major grant + revision deadlines piling up. War reaches far beyond borders — even those who think they’re uninvolved feel it. And yet this inconvenience is nothing compared to what others are enduring. Please choose peace. Humanity first. 000
Reposted by Manvendra SinghJCI insight @insight.jci.org · 23/02/2026Suggesting a potential therapy for these autism-related symptoms and intellectual disability… This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci.... 021
Manvendra Singh @manusingh.bsky.social · 26/02/2026So thrilled to have our research as a cover feature at @insight.jci.org, showing recombinant human Erythropoetin can compensate for the loss of function caused by the genetic mutation. I hope this research will age well. Thanks Hannelore, Klaus, @cakirumut.bsky.social , Justus and ex-colleagues 021
Reposted by Manvendra SinghEric Topol @erictopol.bsky.social · 20/02/2026The $100 whole human genome sequence finally reached! www.sandiegouniontribune.com/2026/02/19/s... 1125477
Reposted by Manvendra SinghMax Haase @maxhaase.bsky.social · 18/02/2026Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14nature.comAncient co-option of LTR retrotransposons as yeast centromeres - NatureEvolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re... 9236119
Manvendra Singh @manusingh.bsky.social · 20/02/2026Phenomenal story, journey and a great thread. Thanks for sharing. Kudos to the entire team. 010
Manvendra Singh @manusingh.bsky.social · 06/02/2026Many Congratulations @retrogenomics.bsky.social , very well deserved and well earned. 🙏🏽 100
Manvendra Singh @manusingh.bsky.social · 30/01/2026Such a great award and the reward too. Very well deserved @m-vincendeau.bsky.social , Many congratulations and hopefully many more to come ☺️ Keep cementing the #TEsky up above and high. 140
Manvendra Singh @manusingh.bsky.social · 29/01/2026Incredible article and resource too. Congratulations @kaessmannlab.bsky.social 140