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Luke Allsopp

@lukeallsopp.bsky.social
728 followers 294 following 34 posts

Senior Lecturer Imperial College London Microbiology Bacteriology Scientist Biofilm Bacteria Nature T6SS and bacterial competition

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Reposted by Luke Allsopp
Sarah Wettstadt @drsarahwettstadt.bsky.social · 25/09/2026
Read my latest short interview for the Science Underdog Series #SciComm #ScienceCommunication #BacterialSuperpowers www.patreon.com/corradonai/p...
patreon.com
Science Underdog Champion: Sarah Wettstadt | Science Underdogs w/ Corrado Nai
I am starting a new series celebrating people who champion science underdogs. This month on September 17 was International Microorganism Day
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Julian Parkhill @julianparkhill.bsky.social · 16/09/2026
This will be an amazing opportunity for the right person. The Department of Veterinary Medicine in Cambridge is recruiting for an established chair who will also be our Head of Department. Your research can be in any area of veterinary science. Please circulate. www.cam.ac.uk/jobs/profess...
cam.ac.uk
Professorship of Veterinary Science
The Board of Electors to the Professorship of Veterinary Science invite applications for this Professorship from persons whose work is connected with veterinary science (ideally in research aligned wi...
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LifeArc @lifearc.bsky.social · 16/09/2026
Why choose a career in cystic fibrosis research? 4 researchers from across the CF Lung Health Network share what motivates them and the difference they hope to make for people living with CF. #CysticFibrosis #ResearchCareer
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NHLI @imperialnhli.bsky.social · 11/09/2026
Luke Allsopp, Associate Professor in Molecular Bacteriology at NHLI, is one of 47 scientists featured in a new book call Scientists Making a Difference 📕 In the book, Luke discusses his research and how his curiosity in the world around him led to a career in STEM. Congratulations Luke 👏
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Luke Allsopp @lukeallsopp.bsky.social · 10/09/2026
Discussing my passion and career in #STEM + #infection in the #ScientistsMakingaDifference book. I work on the bacterium #pseudomonas that’s particularly common in people with #CF #Youngscientists @cysticfibrosis.org.uk @lifearc.bsky.social @imperialnhli.bsky.social @imperialcollegeldn.bsky.social
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Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 02/09/2026
Last year, I publicly complained multiple times (see e.g. elevanth.org/blog/2025/07...) that the open access movement had been captured by publishers, and we are now worse off than before open access. Well people got mad at me for saying it. But I think things are still getting worse.
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Adrian Liston @labliston.bsky.social · 01/09/2026
"There's this concept that circulates that if you don't ace your exams or get into the top university, then basically your whole career is burnt bread," Liston explained. "That's not a healthy framework." That misconception became the spark for the book. www.the-scientist.com/a-stem-caree...
the-scientist.com
A STEM Career Adventure Book for Future Scientists | The Scientist
Inspired by real careers in biomedical science, this interactive narrative-style book lets readers explore how every choice can shape a scientist's future.
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Tanmay Bharat @tbharat-lab.bsky.social · 15/07/2026
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
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Daniel L. Barber, PhD @danbarberphd.bsky.social · 29/04/2026
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology
rdcu.be
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control
Nature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due...
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Patricia Bernal @pbernalt6ss.eurosky.social · 11/07/2026
Fresh out of the lab! Our new preprint is now up on BioRxiv, exploring how the beneficial bacterium Pseudomonas putida controls its T6SS nanoweapon. It turns out the Gac/Rsm pathway acts as a strict molecular brake on the system. 👇 (1/4) Read the full preprint here: doi.org/10.64898/202...
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Luke Allsopp @lukeallsopp.bsky.social · 12/06/2026
Today is wear yellow day for Cystic Fibrosis Trust #CFWeek. Future Imperial Medics doing a Clinical Research & Innovation research experience with Precision-CF Innovation hub in YELLOW! Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk @imperialnhli.bsky.social
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Luke Allsopp @lukeallsopp.bsky.social · 12/06/2026
Today is wear yellow day to raise awareness of and fundraise for #CFWeek. Precision-CF Innovation hub in yellow! Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk @imperialnhli.bsky.social
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LifeArc @lifearc.bsky.social · 24/02/2026
With no treatment available when Michael was diagnosed with SPG50, his dad Terry built a team, launched Elpida and helped create a gene therapy now improving Michael's life. A powerful reminder this #RareDiseaseDay of the support needed for rare conditions.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/02/2026
Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...
Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.
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Microbiology Society @microbiologysociety.org · 24/02/2026
🔍How do fungal-bacterial pathogen interactions worsen disease outcomes? Check out our latest Micro Briefing highlighting new research from The MRC Centre for Medical Mycology at University of Exeter and Mackerere University, Uganda. Read the full paper here🔗 10.1099/jmm.0.002128
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Prof Jenny Rohn @jennyrohn.bsky.social · 22/02/2026
"Precarity is the one constant of academic science. Themes of instability thread themselves through everything we do." A brief blog post from me about the @ukri.org funding pause and who the real victims will be. occamstypewriter.org/mindthegap/2... #AcademicSky
occamstypewriter.org
In which we watch and wait | Mind the Gap
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Nature @nature.com · 20/02/2026
An innovative approach supercharges the innate immune system to provide a first line of defence against respiratory infections. go.nature.com/4qQncQx
go.nature.com
‘Universal vaccine’ protects mice against multiple pathogens
An innovative approach supercharges the innate immune system to provide a first line of defence against respiratory infections.
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Christos C. Ioannou @ccioannou.bsky.social · 18/02/2026
📢📢📢Lectureships at Bristol!📢📢📢 We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline. Great department, great colleagues, great building, great city Details here: www.bristol.ac.uk/jobs/find/de...
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Kirstin-Friederike Heise @kirstinheise.bsky.social · 22/01/2026
journals.plos.org/plosbiology/...
journals.plos.org
Biomedical and life science articles by female researchers spend longer under review
Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...
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Trailfinder CF Innovation Hub @cf-trailfinder.bsky.social · 23/01/2026
Dr. Libby Duignan, CPI Scientist will present her work entitled 'Optimizing Phage Production: Strategies for Scale-Up, Purification and Analysis' at the Viruses of Microbiome 2026 meeting in Newcastle today. @northumbriauni.bsky.social @ukcpi.bsky.social, @cysticfibrosis.org.uk
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Tracy Palmer @proftracypalmer.bsky.social · 23/01/2026
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
findaphd.com
Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com
PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com
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Gregor Weiss @weiss-lab.bsky.social · 19/01/2026
🔬 Postdoc position – Infection Biology & Cryo-ET (Zurich) 🇨🇭 We are looking for a motivated Postdoc to join our interdisciplinary team. 📩 Interested? Check out the job advert: www.imm.uzh.ch/dam/jcr:cb17... 👉 More info on the lab: www.weiss-laboratory.com Please share with interested colleagues!
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Andy Edwards @bugsinblood.bsky.social · 03/12/2025
We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Biozentrum, University of Basel @biozentrum.unibas.ch · 08/12/2025
🧪 New research by @basler-lab.bsky.social reveals a surprising microbial trade-off: Pseudomonas aeruginosa activates a defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. @unibas.ch @snsf.ch @nccr-antiresist.bsky.social 👇
biozentrum.unibas.ch
How bacteria resist hostile attacks
Some bacteria use a kind of molecular “speargun” to eliminate their rivals, injecting them with a lethal cocktail. Researchers led by Prof. Marek Basler at the Biozentrum have now discovered that cert...
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 08/12/2025
🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research
research.pasteur.fr
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 01/12/2025
JB Editor's Choice: Panich, Wadhwa et al. describe a new type of motility in Salmonella they refer to as "swashing", which does not appear to require active propulsion. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
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Allister Crow @allistercrow.bsky.social · 26/11/2025
Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking. A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli. dx.plos.org/10.1371/jour...
dx.plos.org
Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane
In E.coli, three of the four Type VII ABC transporter systems have been structurally characterized. This study solves cryo-EM structures of the fourth Type VII ABC system, YbbAP-TesA, and suggests tha...
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Josie Bryant @josiebryant.bsky.social · 25/11/2025
Really pleased to share the first paper to come out of the lab. We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung. The phylogenies indicate that the clones moved from lung->gut www.nature.com/articles/s41...
nature.com
High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications
Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...
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Basler Lab @basler-lab.bsky.social · 17/11/2025
Happy to share our latest T6SS review: nature.com/articles/s41... Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com
The type VI secretion system and associated effector proteins - Nature Reviews Microbiology
In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...
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LifeArc @lifearc.bsky.social · 19/11/2025
It was powerful to see the many stories of how antibiotics have changed people's lives as part of the Fleming Initiative's takeover of the Piccadilly Lights in London last night. #WAAW2025
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Cystic Fibrosis Trust @cysticfibrosis.org.uk · 19/11/2025
This week is World Antimicrobial Resistance Awareness Week and this #ResearchWednesday we wanted to explain why preventing and tackling antimicrobial resistance is so important to people with #cysticfibrosis. ➡️ www.cysticfibrosis.org.uk/news/improvi...
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Nature Communications @natcomms.nature.com · 19/11/2025
This week is World #AntimicrobialResistance Awareness week To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
bit.ly
World AMR Awareness Week call to action: Patient and public involvement and engagement to improve impact on antimicrobial resistance – the time to act is now
A step change is required in citizen awareness of the global AMR health crisis and, crucially, public involvement in tackling it. The global context presents new challenges but real-world examples show what is possible and an historic moment approaches, that we can leverage for positive action.
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FEMS Journals @femsjournals.bsky.social · 04/10/2025
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use. buff.ly/JST7ZR1
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Connor Sharp @magicmicrobe.bsky.social · 05/11/2025
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...
nature.com
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
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LifeArc @lifearc.bsky.social · 04/11/2025
Rare disease research needs a more integrated and collaborative approach. Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
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Luke Allsopp @lukeallsopp.bsky.social · 22/10/2025
Great kick off meeting for the Precision CF Innovation Hub @imperialnhli.bsky.social @janedaviescf.bsky.social. Awesome talks and a real energy. Thanks to funders @lifearc.bsky.social and @cysticfibrosis.org.uk
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 21/10/2025
New in JB: Bhattacharya, Zhang, & Yu review the current state of knowledge around protein trafficking across the membrane by gram-positive bacteria with a focus on the model organisms Bacillus subtilis and Staphylococcus aureus. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
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Trailfinder CF Innovation Hub @cf-trailfinder.bsky.social · 22/10/2025
Today is #WorldPhageDay! One of our key aims is to advance #phagetherapy, which uses natural viruses called #phage to target bacteria instead of antibiotics. We are working to develop new phage combinations, test the best way of giving them, and ensure the UK can produce phage at medical standards.
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Tiago Costa @tcostalab.bsky.social · 09/09/2025
Thrilled to share that two of our papers with @jrpenades.bsky.social & GoogleDeepMind are now out in @cellpress.bsky.social 1️⃣Microbial piracy: tinyurl.com/yvf6t3b3 2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj @imperialcollegeldn.bsky.social @imperiallifesci.bsky.social
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Harry Low’s Lab @lowlab.bsky.social · 28/07/2025
Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏 www.imperial.ac.uk/media/imperi...
imperial.ac.uk
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Asaf Levy @asaflevylab.bsky.social · 22/10/2024
Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins: www.nature.com/articles/s41...
nature.com
Systematic discovery of antibacterial and antifungal bacterial toxins - Nature Microbiology
Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.
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Asaf Levy @asaflevylab.bsky.social · 29/06/2025
Preparing for ETOX meeting in Bilbao with Yaara, Tracy, and Luke @lukeallsopp.bsky.social @proftracypalmer.bsky.social
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David Gaboriau @dgaboriau.bsky.social · 20/06/2025
This week I celebrate 10 years at FILM, the Facility for Imaging by Light Microscopy @imperialcollegeldn.bsky.social @imperialnhli.bsky.social Thank you to all the students, researchers and colleagues who used the facility and supported us! Here's to many more years of imaging 🥳🎉🔬
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Luke Allsopp @lukeallsopp.bsky.social · 13/06/2025
Now that’s commitment!
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NHLI @imperialnhli.bsky.social · 13/06/2025
Today is Wear Yellow Day to raise awareness of and fundraise for Cystic Fibrosis. Teams of @janedaviescf.bsky.social, @lukeallsopp.bsky.social and Hughes in yellow. Researching towards unlocking a life unlimited for people with CF ‪@cysticfibrosis.org.uk www.cysticfibrosis.org.uk/get-involved...
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NHLI @imperialnhli.bsky.social · 11/06/2025
Harriet Ellis, a postdoc in @lukeallsopp.bsky.social's Group, is uncovering how Pseudomonas aeruginosa – a key bacterial threat in cystic fibrosis – adapts & causes infection. 💛🦠 #CFweek Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
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Luke Allsopp @lukeallsopp.bsky.social · 09/06/2025
#Myth busting #immunology, promoting #critical thinking and the awe of #science !!! Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
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Luke Allsopp @lukeallsopp.bsky.social · 09/06/2025
Enjoyed @dandavis101.bsky.social lecture at @ri-science.bsky.social on Saturday night. Myth busting and promoting critical thinking with a clear passion for scientific discovery!!
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