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Lukas Heumos

@lukasheumos.bsky.social
499 followers 147 following 19 posts

Sr Solution Architect Genomics @NVIDIA | Co-founder @scverse | Postdoc at @theislab Views and opinions expressed on this account are those of my own and do not represent those of my employer, NVIDIA.

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Reposted by Lukas Heumos
Rob Patro @robp.bsky.social · 27/08/2026
While we are still working on the first feature/perf full release of the rustar-aligner, you can currently use the main branch to build a byte-compatible STAR index >2x faster with <1/2 of the RAM (and use it with STAR). Plus it fixes a small STAR bug github.com/scverse/rust...
github.com
GitHub - scverse/rustar-aligner: A rust implementation of STAR
A rust implementation of STAR. Contribute to scverse/rustar-aligner development by creating an account on GitHub.
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Gregor Sturm @grst.bsky.social · 29/05/2026
Happy to announce the release of IggyTop, a metadatabase for immune receptor–epitope interactions. It's integrated with scirpy v0.24 so you can readily use it to annotate your single-cell TCR datasets. iggytop.readthedocs.io/en/latest/
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Gregor Sturm @grst.bsky.social · 29/05/2026
This started as a collaboration with biocypher (@slobentanzer.bsky.social) at a @scverse.bsky.social hackathon, was then advanced by @valeriiadragan.bsky.social as a master thesis project and finally pushed over the finish line by Raphael De Gottardi
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scverse @scverse.bsky.social · 27/05/2026
scverse conference 2026 will take place in Copenhagen, October 12–14. ✨ Three days of all-things-single-cell and open-source tooling and community in real life. More details soon but for now, mark your calendars. scverse.org/conference20... See you in Copenhagen 🇩🇰
scverse.org
scverse conference 2026
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Luke Zappia @lazappi.bsky.social · 23/04/2026
Last week I attended a SpatialData hackathon with members of the @scverse.bsky.social, @bioconductor.bsky.social and @openmicroscopy.org communities in Padua, Italy. Here is a short blog post about the experience www.data-intuitive.com/insights/blo....
data-intuitive.com
2nd SpatialData Hackathon – Data Intuitive
Frameworks, formats and Interoperability
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Fabian Theis @fabiantheis.bsky.social · 17/03/2026
Excited to share new preprint with NVIDIA on GPU-accelerated single-cell analysis 🚀 rapids-singlecell brings native GPU support to scverse/AnnData: hours → seconds (1M cells: ~52m → ~25s), scaling to 100M cells. Huge thanks to Severin Dicks 🙌 📄 arxiv.org/abs/2603.02402
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scverse @scverse.bsky.social · 26/02/2026
We're excited to announce that registration for our upcoming Spatial Omics workshop has opened! Details in 🧵
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Luke Zappia @lazappi.bsky.social · 17/02/2026
Nice blog post from @thomas-sandmann.genomic.social.ap.brid.gy testing out {anndataR} 📦 tomsing1.github.io/blog/posts/a... 🎉! Cool to see people trying it out, find it on @bioconductor.bsky.social if you want to give it a go bioconductor.org/packages//re...
tomsing1.github.io
anndataR: converting single-cell data, from R to python and back – Thomas Sandmann’s blog
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Lukas Heumos @lukasheumos.bsky.social · 05/02/2026
It's kind of insane that I need a firefox addon for every LLM chat interface to enforce usage of the (full) width of my screen
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Fabian Theis @fabiantheis.bsky.social · 03/02/2026
🚀 Interested in a postdoc in computational biology & AI for neuroscience? The NOMIS Synergy Fellowship offers a great opportunity to develop such a position in my lab within the interdisciplinary Synergy excellence cluster. 🔗 www.synergy-munich.de/news-events/...
synergy-munich.de
NOMIS–SyNergy Fellowship Program in Systems Neurology (Munich, Germany) | SyNergy - Munich Cluster for Systems Neurology
The NOMIS Foundation, in collaboration with the DFG-funded Munich Cluster for Systems Neurology (SyNergy), invites exceptional early-career scientists from around the world to apply for elite…
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Reposted by Lukas Heumos
Erick Ratamero @erickratamero.com · 14/01/2026
Big news! The Data Management team/Data Science Centre at EMBL (i.e. my team) is hiring for a position based in Heidelberg (but working across all sites!). We are looking for a scientific workflows developer that will focus on multimodal pipelines. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Scientific Workflows Developer
The European Molecular Biology Laboratory (EMBL) is Europe’s life sciences laboratory – an intergovernmental organisation with more than 110 independent research groups and service teams covering the ...
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Nature Methods @natmethods.nature.com · 14/01/2026
Pertpy: a one-stop and performant framework for single-cell perturbation analysis. @lukasheumos.bsky.social @fabiantheis.bsky.social www.nature.com/articles/s41...
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Emma Dann @emmamarydann.bsky.social · 05/01/2026
Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025
tinyurl.com
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...
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Reposted by Lukas Heumos
Rob Patro @robp.bsky.social · 03/01/2026
While we've been somewhat successful in spurring adoption of alevin-fry/simpleaf for scRNAseq processing, an impediment Dongze brought to our attention (now working directly w/ many experimentalists) was the need for a nice QC report for it's output; hence QCatch www.biorxiv.org/content/10.1... 1/x
biorxiv.org
QCatch: A framework for quality control assessment and analysis of single-cell sequencing data
Motivation: Single-cell sequencing data analysis requires robust quality control (QC) to mitigate technical artifacts and ensure reliable downstream results. While tools like alevin-fry and simpleaf (...
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Machine Learning in Science @mackelab.bsky.social · 28/11/2025
We are looking for a Research Engineer (E13 TV-L) to work at the intersection of #ML and #compneuro! 🤖🧠 Help us build large-scale bio-inspired neural networks, write high-quality research code, and contribute to open-source tools like jaxley, sbi, and flyvis 🪰. More info: www.mackelab.org/jobs/
mackelab.org
Jobs - mackelab
The MackeLab is a research group at the Excellence Cluster Machine Learning at Tübingen University!
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Pau Badia i Mompel @paubadiam.bsky.social · 21/11/2025
scverse conference 2025 done ✅ Really engaging week at Stanford with scPerturb-seq work, agentic models in biology, and strong interest in scaling software to millions of cells. Organizing alongside the rest of the @scverse.bsky.social team was a blast! Hope attendees found it productive 😄
All scverse attendeesscverse conference organizersFirst session
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Lukas Heumos @lukasheumos.bsky.social · 06/11/2025
Excited to see a home for MCP servers in bioinformatics emerge! The community needs a central hub for developing MCP servers for key bioinfo tools. At @scverse.bsky.social we're contributing to this effort - can't wait to share what we're building
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Reposted by Lukas Heumos
scverse @scverse.bsky.social · 04/11/2025
Meet the keynote speakers for the 2025 scverse conference! Erika Alden DeBenedictis, Co-founder of The Align Foundation 🧵 @erika-alden.bsky.social @alignbio.bsky.social @pioneerlabs.bsky.social #scverse #scverse2025 #StructuralBiology #Biotech #Stanford
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scverse @scverse.bsky.social · 16/10/2025
🌟 Thank You to Our Platinum Sponsor: 10x Genomics! 🌟 We're delighted to recognize 10x Genomics as a Platinum Sponsor of scverse conference 2025! 🏆 @10xgenomics.bsky.social #scverse2025 #ComputationalBiology #SingleCell #SpatialOmics #10xGenomics #Bioinformatics #Biotechnology
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Rob Patro @robp.bsky.social · 10/10/2025
Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬
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Luca Marconato @lucamarconato.bsky.social · 12/09/2025
My favorite part of last-year #scverse conference was to finally meet in-person many developers that I only knew from their GitHub username! Submissions and travel grant applications close in 3 days. Find out more and apply at scverse.org/conference2025 @scverse.bsky.social
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Anshul Kundaje @anshulkundaje.bsky.social · 26/08/2025
scVerse conference is at Stanford this year! Encourage folks (especially Bay Area/West coast folks) to sign up and attend. Cool workshops/talks and other events + great community of developers for one of the most widely used open source software for single cell data analysis!
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Lukas Heumos @lukasheumos.bsky.social · 18/08/2025
It is pretty heart warming to see people start their really good pull request with "this is my first open source contribution. I hope that this is good.". Everyone starts somewhere and we're always happy to guide at @scverse.bsky.social .
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Reposted by Lukas Heumos
Gregor Sturm @grst.bsky.social · 13/08/2025
Our benchmark + guidelines for atlas-level differential gene expression of single cells is online: academic.oup.com/bib/article/... Bottom line: Use pseudobulk + DESeq2 in simple and pseudobulk + DREAM in more complex settings. Collab w/ @leonhafner.bsky.social @itisalist.bsky.social
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Lukas Heumos @lukasheumos.bsky.social · 08/08/2025
I hate reference limits of journals so much. I'm sitting here trying to find a few more references to remove despite me knowing that I'll either remove context & evidence for scientific conclusions or not mention tools that very much deserve to be mentioned and cited.
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Reposted by Lukas Heumos
Malte Kuehl @maltekuehl.com · 29/07/2025
Preprint alert 🚨 Do you use chatbots in your work or even build MCP servers and agentic systems yourself? Or would you like to find a way to use biomedical tools using natural language? Then check out biocontext.ai, now out on bioRxiv: www.biorxiv.org/content/10.1...
Diagram showing MCP-enabled research architecture. Part A illustrates the flow between MCP servers (including BioContextAI Knowledgebase MCP and Community-developed MCP servers), Agentic systems connected via Model Context Protocol, and researchers asking research questions. MCP servers connect to knowledgebases and specialized software. Part B details the BioContextAI project components, divided into Registry (Schema.org ontology, Web interface, Open source licensing, MCP-enabled chatbot, Continuous integration) and Community (Documentation, Community forums, MCP server reviews, Shareable collections, Interoperability with tools like BioChatter).
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scverse @scverse.bsky.social · 23/06/2025
We will have our next community meeting on Tuesday, 2025-06-24 at 18:00 CEST! Sneha Mitra (@snehamitra.bsky.social) will speak about SCARlink. (Zoom registration link and more information in thread!)
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Pau Badia i Mompel @paubadiam.bsky.social · 12/06/2025
Happy to have this finally out! Check out the updated vignettes and if something is broken please open a GitHub issue and I'll have a look 😉👇
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mariuslange.bsky.social @mariuslange.bsky.social · 28/03/2025
Happy to share CellAnnotator, a lightweight Python package to query OpenAI models for initial cell type annotations: github.com/quadbio/cell... Inspired by ideas in www.nature.com/articles/s41... and github.com/VPetukhov/GP..., implemented as an scVerse ecosystem package with docs and tutorials.
github.com
GitHub - quadbio/cell-annotator: Automatically annotate cell types, consistently across samples.
Automatically annotate cell types, consistently across samples. - quadbio/cell-annotator
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scverse @scverse.bsky.social · 14/04/2025
Tomorrow at 2025-04-15 18:00 CEST, we’ll have our next community meeting! Anastasia Litinetskaya will present “Multimodal integration and identification of disease-specific changes in single-cell atlases”. Check out the GitHub repo here: github.com/theislab/mul...
github.com
GitHub - theislab/multimil: Multimodal weakly supervised learning to identify disease-specific changes in single-cell atlases
Multimodal weakly supervised learning to identify disease-specific changes in single-cell atlases - theislab/multimil
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Mikaela Koutrouli @mkoutrouli.bsky.social · 14/04/2025
We are back 🔥
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Nature Reviews Genetics @natrevgenet.nature.com · 17/02/2025
Best practices for single-cell analysis across modalities go.nature.com/4gJkk3c #ExpertRecommendation by @lukasheumos.bsky.social et al. (from the @fabiantheis.bsky.social lab) - now nearing 250k accesses! Free to read here: rdcu.be/eabUB
go.nature.com
Best practices for single-cell analysis across modalities - Nature Reviews Genetics
Practitioners in the field of single-cell omics are now faced with diverse options for analytical tools to process and integrate data from various molecular modalities. In an Expert Recommendation art...
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scverse @scverse.bsky.social · 14/02/2025
🎉 Scanpy 1.11.0 is out! 🎉 just after reaching 2000 stars on GitHub! - sc.pp.sample replaces subsample with many new features - Sparse Dask support pca - session-info2 package for more reproducible notebooks See the release notes:
buff.ly
Release notes
Version 1.11: 1.11.0 2025-02-14: Release candidates: rc2 2025-01-24, rc1 2024-12-20. Features: rc1 sample() supports both upsampling and downsampling of observations and variables. subsample() is n...
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Lukas Heumos @lukasheumos.bsky.social · 30/01/2025
We have additional available spots. Please consider joining! It will be a blast.
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Lukas Heumos @lukasheumos.bsky.social · 22/01/2025
I keep being astonished at how terrible @microsoft.com Teams works on Firefox and I certainly don't blame Mozilla for it.
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Lukas Heumos @lukasheumos.bsky.social · 21/01/2025
Ahhh finally I can use @nextflow.io to run doom! github.com/nextflow-io/...
github.com
GitHub - nextflow-io/doom: A Nextflow pipeline to play Doom
A Nextflow pipeline to play Doom. Contribute to nextflow-io/doom development by creating an account on GitHub.
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Lukas Heumos @lukasheumos.bsky.social · 17/01/2025
I am Stoked about our upcoming @scverse.bsky.social and @owkin.bsky.social hackathon, focused on spatial omics data analysis. 📅 March 17-19, 2025 📍 Owkin office, Paris Apply now: docs.google.com/forms/d/e/1F...
docs.google.com
Scverse x Owkin Hackathon in Paris
We're pleased to announce the next Scverse Hackathon will take place in the Owkin offices in Paris from 17/03/2025 9am to 19/03/2025 1:30pm. This hackathon is a joint initiative between the scverse c...
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Lukas Heumos @lukasheumos.bsky.social · 14/01/2025
Why is there still no proper "thank you" emoji on @github.com ? I am grateful for other peoples time and feel like a thumbs up is kind of like a drive by reaction and a heart isn't always perfectly appropriate
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Lukas Heumos @lukasheumos.bsky.social · 10/01/2025
I actually think that it' awesome that even fundamental packages like numpy, pandas, scipy, and others still develop rapidly and aren't afraid of making big API changes but it's quite time consuming to keep up when one maintains many packages. I can't imagine what e.g. the numba devs go through
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Lukas Heumos @lukasheumos.bsky.social · 15/12/2024
I was just looking at our @scverse.bsky.social zulip chat statistics and am super happy about our steady and healthy growth. The two bursts are our official launch in May 2022 and the inaugural scverse conference in September of 2024. Please join us! scverse.zulipchat.com
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scverse @scverse.bsky.social · 10/12/2024
Reminder!Today at 18:00 CET will be the last community meeting of the year! @lukasheumos.bsky.social will talk about about pertpy, a Python-based modular framework for the analysis of large-scale perturbation single-cell experiments. Zoom link can be found here: scverse.zulipchat.com#narrow/chann...
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scverse @scverse.bsky.social · 03/12/2024
Next Tuesday at 2024-12-10 18:00 CET, we will hold the last community meeting of the year! @lukasheumos.bsky.social will talk about pertpy, a Python-based modular framework for the analysis of large-scale perturbation single-cell experiments. The GitHub repo: github.com/scverse/pertpy
github.com
GitHub - scverse/pertpy: Perturbation Analysis in the scverse ecosystem.
Perturbation Analysis in the scverse ecosystem. Contribute to scverse/pertpy development by creating an account on GitHub.
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scverse @scverse.bsky.social · 26/11/2024
Reminder! Today at 18:00 CET will be another community meeting! Malte Lücken will talk about about Open Problems in Single-Cell Analysis. Zoom link can be found here:
buff.ly
If this message does not go away, try reloading the page.
If this message does not go away, try reloading the page.
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scverse @scverse.bsky.social · 20/11/2024
Next Tuesday at 2024-11-26 18:00 CET will be another community meeting! Malte Lücken will talk about about Open Problems in Single-Cell Analysis, a community-driven state-of-the-art benchmarking platform to facilitate development of single-cell methods. buff.ly/3CAGxSt
openproblems.bio
Open Problems in Single-Cell Analysis – Open Problems in Single Cell Analysis
Computational biology is undergoing a revolution. Recent advances in microfluidic technology enable high-throughput and high-dimensional of individual cells at unprecedented scale. But there’s a…
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scverse @scverse.bsky.social · 16/11/2024
Explore the scverse Starter Pack! Stay informed about the latest scverse events, software updates, and community news. Everything you need to know about foundational tools for single-cell omics analysis in one place. go.bsky.app/UvFMa8d
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Leander @le-and-er.bsky.social · 21/11/2024
Super excited to share our Human Neural Organoid Atlas, now out in Nature! Led by @zhisonghe.bsky.social @josch1.bsky.social, and myself, this resource was created from 36 scRNA-seq datasets—totalling over 1.7 million cells! 🔬✨
 www.nature.com/articles/s41...
 Find out how it can serve you ⏬
 🧵1/8
nature.com
An integrated transcriptomic cell atlas of human neural organoids - Nature
A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...
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Fabian Theis @fabiantheis.bsky.social · 20/11/2024
Thanks - really nice w these starter packs, did that. Meanwhile @scverse.bsky.social has also created one - really like that. bsky.app/starter-pack...
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Lukas Heumos @lukasheumos.bsky.social · 18/11/2024
I am stoked to see our EHR framework ehrapy (github.com/theislab/ehr...) being the cover of the most recent Nature Medicine issue. We consider ehrapy a MVP for a much grander ecosystem for EHR analysis like we have for single-cell data (@scverse). Read more: www.nature.com/articles/s41...
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