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Machine Learning in Science

@mackelab.bsky.social
2.6K followers 198 following 128 posts

We build probabilistic #MachineLearning and #AI Tools for scientific discovery, especially in Neuroscience. Probably not posted by @jakhmack.bsky.social. 📍 @ml4science.bsky.social‬, Tübingen, Germany

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Reposted by Machine Learning in Science
Matthijs Pals @matthijspals.bsky.social · 28/09/2026
What are the dynamics underlying sequence working memory? To found out, we develop and analyse RNNs fitted to multi-session single-unit data of macaques. See my talk Wed 12:00, at @bernsteinneuro.bsky.social. With @jakhmack.bsky.social @mackelab.bsky.social Data from Chen et al., Neuron 2024.
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Machine Learning in Science @mackelab.bsky.social · 28/09/2026
The Macke lab is back at @bernsteinneuro.bsky.social in Frankfurt! 🧠🪰 This year with 2 satellite workshop talks + 5 posters on mechanistic, connectome-constrained models of the fruit fly. All posters are joint work with @srinituraga.bsky.social. Come and say hi! 👋 Details 👇 (1/8)
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Reposted by Machine Learning in Science
Jakob Macke @jakhmack.bsky.social · 14/07/2026
We are excited to announce up to 3 PhD positions in a new project on using ML for "Extracting Probabilistic Representations in Exponential Quantum Spaces" (EXPRESSO) with @philipphennig.bsky.social , @mariokrenn.bsky.social, Igor Lesanovsky, @gmartius.bsky.social in the @ml4science.bsky.social.
quantiki.org
PhD Positions in Quantum Physics and Machine Learning | Quantiki
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Machine Learning in Science @mackelab.bsky.social · 06/07/2026
Mackelab is at @icmlconf.bsky.social in Seoul 🇰🇷 Two papers on simulation-based and model-based scientific discovery this year. Come say hi!
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Machine Learning in Science @mackelab.bsky.social · 02/07/2026
We congratulate @matthijspals.bsky.social on his successful PhD defense! During his time in the Mackelab, he used RNNs to link neural activity with underlying mechanisms. Now he moved on to a Postdoc position in @durstewitzlab.bsky.social at the ZI Mannheim and the University of Heidelberg.
Left to right: Philipp Berens, Anna Levina, Matthijs Pals, Peter Dayan, Jakob Macke.
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Machine Learning in Science @mackelab.bsky.social · 26/06/2026
New paper: We recast automated scientific model discovery with LLMs as Bayesian inference! LLMs write code and carry domain knowledge, great for proposing models. The key idea: discovery is inference, not just generation. What distribution of models explains the data? 🧵 arxiv.org/abs/2602.18266
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Machine Learning in Science @mackelab.bsky.social · 30/03/2026
Come and work with us! We have a PostDoc position at the intersection of ML and Biogeoscience within the TERRA excellence cluster @terra-cluster.org, w/ Senckenberg. Be part of a great ML and Geo community and use ML to investigate fire and its impact on global vegetation🔥 🌱🌳 www.mackelab.org/jobs/
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Machine Learning in Science @mackelab.bsky.social · 11/03/2026
@mackelab.bsky.social is at @cosynemeeting.bsky.social #cosyne2026 in Lisbon with two posters presented by PhD students from the lab. Thread below on the projects 👇
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Machine Learning in Science @mackelab.bsky.social · 16/02/2026
The PhD graduation streak continues with Dr. Janne Lappalainen (@lappalainenjk.bsky.social) and Dr. Auguste Schulz (@auschulz.bsky.social) successfully defending in January and February. Congratulations!
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Machine Learning in Science @mackelab.bsky.social · 13/01/2026
Happy 2026 everyone! Two freshly minted PhDs 🧑‍🎓emerged from our lab at the end of last year. We congratulate Dr Julius Vetter (@vetterj.bsky.social) and Dr Guy Moss (@gmoss13.bsky.social)! Here seen celebrating with the lab 🎳. 1/3
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Machine Learning in Science @mackelab.bsky.social · 01/12/2025
Our group is at NeurIPS and EurIPS this year with four papers and one workshop poster. If you are either curious about SBI with autoML, with foundation models, or on function spaces or about differentiable simulators with Jaxley, have a look below 👇 1/11
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Reposted by Machine Learning in Science
Guy Moss @gmoss13.bsky.social · 01/12/2025
I’m super excited to present our new work in #Eurips2025 and #Neurips2025! We developed FNOPE: a new simulation-based inference (SBI) method which excels at inferring function-valued parameters! Paper: openreview.net/forum?id=yB5... Code: github.com/mackelab/fnope (1/9)
openreview.net
FNOPE: Simulation-based inference on function spaces with Fourier...
Simulation-based inference (SBI) is an established approach for performing Bayesian inference on scientific simulators. SBI so far works best on low-dimensional parametric models. However, it is...
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Machine Learning in Science @mackelab.bsky.social · 28/11/2025
We are looking for a Research Engineer (E13 TV-L) to work at the intersection of #ML and #compneuro! 🤖🧠 Help us build large-scale bio-inspired neural networks, write high-quality research code, and contribute to open-source tools like jaxley, sbi, and flyvis 🪰. More info: www.mackelab.org/jobs/
mackelab.org
Jobs - mackelab
The MackeLab is a research group at the Excellence Cluster Machine Learning at Tübingen University!
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Machine Learning in Science @mackelab.bsky.social · 28/11/2025
MackeLab has grown! 🎉 Warm welcome to 5(!) brilliant and fun new PhD students / research scientists who joined our lab in the past year — we can’t wait to do great science and already have good times together! 🤖🧠 Meet them in the thread 👇 1/7
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Machine Learning in Science @mackelab.bsky.social · 21/11/2025
Simulation-based inference (SBI) has transformed parameter inference across a wide range of domains. To help practitioners get started and make the most of these methods, we joined forces with researchers from many institutions and wrote a practical guide to SBI. 📄 Paper: arxiv.org/abs/2508.12939
arxiv.org
Simulation-Based Inference: A Practical Guide
A central challenge in many areas of science and engineering is to identify model parameters that are consistent with prior knowledge and empirical data. Bayesian inference offers a principled framewo...
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Machine Learning in Science @mackelab.bsky.social · 13/11/2025
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al. Paper: www.nature.com/articles/s41...
nature.com
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
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Machine Learning in Science @mackelab.bsky.social · 02/10/2025
Congrats to Dr Michael Deistler @deismic.bsky.social, who defended his PhD! Michael worked on "Machine Learning for Inference in Biophysical Neuroscience Simulations", focusing on simulation-based inference and differentiable simulation. We wish him all the best for the next chapter! 👏🎓
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Machine Learning in Science @mackelab.bsky.social · 30/09/2025
The Macke lab is well-represented at the @bernsteinneuro.bsky.social conference in Frankfurt this year! We have lots of exciting new work to present with 7 posters (details👇) 1/9
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Reposted by Machine Learning in Science
sbi - Simulation-based inference @sbi-devs.bsky.social · 09/09/2025
From hackathon to release: sbi v0.25 is here! 🎉 What happens when dozens of SBI researchers and practitioners collaborate for a week? New inference methods, new documentation, lots of new embedding networks, a bridge to pyro and a bridge between flow matching and score-based methods 🤯 1/7 🧵
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Machine Learning in Science @mackelab.bsky.social · 23/07/2025
New preprint: SBI with foundation models! Tired of training or tuning your inference network, or waiting for your simulations to finish? Our method NPE-PF can help: It provides training-free simulation-based inference, achieving competitive performance with orders of magnitude fewer simulations! ⚡️
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Reposted by Machine Learning in Science
The Transmitter @thetransmitter.bsky.social · 30/06/2025
The neurons that encode sequential information into working memory do not fire in that same order during recall, a finding that is at odds with a long-standing theory. Read more in this month’s Null and Noteworthy. By @ldattaro.bsky.social #neuroskyence www.thetransmitter.org/null-and-not...
thetransmitter.org
Null and Noteworthy: Neurons tracking sequences don’t fire in order
Instead, neurons encode the position of sequential items in working memory based on when they fire during ongoing brain wave oscillations—a finding that challenges a long-standing theory.
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Machine Learning in Science @mackelab.bsky.social · 02/07/2025
Many people in our lab use Scholar Inbox regularly -- highly recommended!
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Machine Learning in Science @mackelab.bsky.social · 11/06/2025
Thrilled to share that our paper on using simulation-based inference for inferring ice accumulation and melting rates for Antarctic ice shelves is now published in Journal of Glaciology! www.cambridge.org/core/journal...
cambridge.org
Simulation-based inference of surface accumulation and basal melt rates of an Antarctic ice shelf from isochronal layers | Journal of Glaciology | Cambridge Core
Simulation-based inference of surface accumulation and basal melt rates of an Antarctic ice shelf from isochronal layers - Volume 71
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Reposted by Machine Learning in Science
sbi - Simulation-based inference @sbi-devs.bsky.social · 12/05/2025
Great news! Our March SBI hackathon in Tübingen was a huge success, with 40+ participants (30 onsite!). Expect significant updates soon: awesome new features & a revamped documentation you'll love! Huge thanks to our amazing SBI community! Release details coming soon. 🥁 🎉
A wide shot of approximately 30 individuals standing in a line, posing for a group photograph outdoors. The background shows a clear blue sky, trees, and a distant cityscape or hills.
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Machine Learning in Science @mackelab.bsky.social · 30/04/2025
🎓Hiring now! 🧠 Join us at the exciting intersection of ML and Neuroscience! #AI4science We’re looking for PhDs, Postdocs and Scientific Programmers that want to use deep learning to build, optimize and study mechanistic models of neural computations. Full details: www.mackelab.org/jobs/ 1/5
mackelab.org
Jobs - mackelab
The MackeLab is a research group at the Excellence Cluster Machine Learning at Tübingen University!
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Machine Learning in Science @mackelab.bsky.social · 25/04/2025
Excited to present our work on compositional SBI for time series at #ICLR2025 tomorrow! If you're interested in simulation-based inference for time series, come chat with Manuel Gloeckler or Shoji Toyota at Poster #420, Saturday 10:00–12:00 in Hall 3. 📰: arxiv.org/abs/2411.02728
arxiv.org
Compositional simulation-based inference for time series
Amortized simulation-based inference (SBI) methods train neural networks on simulated data to perform Bayesian inference. While this strategy avoids the need for tractable likelihoods, it often requir...
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Reposted by Machine Learning in Science
Auguste Schulz @auschulz.bsky.social · 17/04/2025
Thanks so much for the shout-out, and congrats on your exciting work!! 🎉 🙂 Also, a good reminder to share that our work is now out in Cell Reports 🙏🎊 ⬇️ www.cell.com/cell-reports...
cell.com
Modeling conditional distributions of neural and behavioral data with masked variational autoencoders
Schulz et al. demonstrate how neural encoding and decoding can be cast as computing conditional distributions and how to modify variational autoencoders (VAEs) to calculate such distributions. The pro...
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Machine Learning in Science @mackelab.bsky.social · 27/03/2025
The @mackelab.bsky.social is represented at @cosynemeeting.bsky.social #cosyne2025 in Montreal with 3 posters, 2 workshop talks, and a main conference contributed talk (for the very first time in Mackelab history 🎉)!
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Reposted by Machine Learning in Science
ML for Science @ml4science.bsky.social · 24/03/2025
Exciting new paper out of a Tübingen-Bonn collaboration, with three researchers from our cluster involved: first author @stefanieliebe.bsky.social, @matthijspals.bsky.social & @mackelab.bsky.social. Congrats to the team!
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C3N @c3neuro.bsky.social · 24/03/2025
Science Alert 🚨: Our paper is now out in @natureneuro.bsky.social - We show that the firing phase of neurons in human MTL doesn’t reflect the order of events, challenging a long-standing theory of human memory. nature.com/articles/s41593-025-01893-7
nature.com
Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks - Nature Neuroscience
The temporal order of events in working memory is thought to be reflected by ordered neuronal firing at different phases. Here the authors show that this is not the case and that phase order is linked...
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Reposted by Machine Learning in Science
Michael Deistler @deismic.bsky.social · 28/02/2025
Together with @dendritesgr.bsky.social, we’ll be hosting a tutorial on constructing and optimizing biophysical models (via Jaxley & DendroTweaks) 🚀 Join us in Florence if you like dendrites, biophysics, or optimization!
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Reposted by Machine Learning in Science
Auguste Schulz @auschulz.bsky.social · 03/02/2025
1) Some exciting science in turbulent times: How do mice distinguish self-generated vs. object-generated looming stimuli? Our new study combines VR and neural recordings from superior colliculus (SC) 🧠🐭 to explore this question. Check out our preprint doi.org/10.1101/2024... 🧵
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Machine Learning in Science @mackelab.bsky.social · 13/12/2024
Talk to @vetterj.bsky.social and @gmoss13.bsky.social about sourcerer at #Neurips2024 today! 📍Poster #4006 (East; 11 am PT)
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Reposted by Machine Learning in Science
Auguste Schulz @auschulz.bsky.social · 11/12/2024
1) With our @neuripsconf.bsky.social poster happening tomorrow, it's about time to introduce our Spotlight paper 🔦, co-lead with @jkapoor.bsky.social: Latent Diffusion for Neural Spiking data (LDNS), a latent variable model (LVM) which addresses 3 goals simultaneously:
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Reposted by Machine Learning in Science
Matthijs Pals @matthijspals.bsky.social · 11/12/2024
How to find all fixed points in piece-wise linear recurrent neural networks (RNNs)? A short thread 🧵 
In RNNs with N units with ReLU(x-b) activations the phase space is partioned in 2^N regions by hyperplanes at x=b 1/7
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Machine Learning in Science @mackelab.bsky.social · 09/12/2024
Thrilled to announce we have three #NeurIPS2024 papers! Interested in simulating realistic neural data with diffusion models or recurrent neural networks, or in source distribution sorcery? Have a look 👇 1/4
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Jakob Macke @jakhmack.bsky.social · 27/11/2024
Watching the sbi-toolbox grow up, seeing its many uses on a wide range of applications, and experiencing the growth, momentum + team-spirit of the sbi community has been amazing. We now have a short software paper with many new contributions and contributors! So many thanks, and get involved!
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sbi - Simulation-based inference @sbi-devs.bsky.social · 27/11/2024
The sbi package is growing into a community project 🌍 To reflect this and the many algorithms, neural nets, and diagnostics that have been added since its initial release, we have written a new software paper 📝 Check it out, and reach out if you want to get involved: arxiv.org/abs/2411.17337
arxiv.org
sbi reloaded: a toolkit for simulation-based inference workflows
Scientists and engineers use simulators to model empirically observed phenomena. However, tuning the parameters of a simulator to ensure its outputs match observed data presents a significant challeng...
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Machine Learning in Science @mackelab.bsky.social · 14/11/2024
To introduce our science, let’s start with: we are hiring! Inspired to do a PhD or Postdoc in #AI4Science? Work with us on ML tools for scientific discovery. Full details: www.mackelab.org/jobs/ PhD students: Apply by Nov 15 (tomorrow!), directly to IMPRS-IS or ELLIS
mackelab.org
Jobs - mackelab
The MackeLab is a research group at the Excellence Cluster Machine Learning at Tübingen University!
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Machine Learning in Science @mackelab.bsky.social · 14/11/2024
Hi world! This is the brand-new BlueSky account of the Machine Learning in Science (@jakhmack.bsky.social) lab. We create probabilistic #MachineLearning and #AI Tools for scientific discovery — but more on that soon! For now let’s introduce ourselves with some pictures of our recent group retreat.
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