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Luke Zappia

@lazappi.bsky.social
1.1K followers 335 following 55 posts

Bioinformatician, data scientist, software developer Also @_lazappi_ and @lazappi@mastodon.au

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Reposted by Luke Zappia
Yihui Xie @yihui.org · 21/09/2026
After a massive cleanup of knitr issues/PRs in the past few days, I can finally stop being jealousy of Will Landau for his zero open Github issues in {targets}: yihui.org/en/2026/09/k... For the record, he has one open issue at the moment and so do I (debating with myself whether I should close it).
yihui.org
A Four-Day knitr Issue/PR Backlog Sprint - Yihui Xie | 谢益辉
After knitr v1.52 went to CRAN on 2026-09-06, I did something I don’t do often but have been hoping to do: I sat down and worked through the GitHub issue tracker more or less top to bottom. Over...
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Bioconductor @bioconductor.bsky.social · 04/08/2026
📢 Join BioC2026 online! Although in-person registration for BioC2026 is now closed, you can still join the conference virtually from anywhere in the world. 💻 Virtual registration closes: August 12 Secure your virtual ticket today: 🎟️ ti.to/nf-projects/...
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Luke Zappia @lazappi.bsky.social · 10/06/2026
Excited that the {anndataR} 📦 publication is out academic.oup.com/bioinformati... 🎉! I hope this makes it easier to move single-cell data between R and Python and encourages people to take advantage of both languages. Check it out on @bioconductor.bsky.social bioconductor.org/packages/ann....
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Luke Zappia @lazappi.bsky.social · 12/05/2026
My quick wrap up of the recent @bioconductor.bsky.social 3.23 release focusing on single-cell and other things I'm interested in lazappi.id.au/posts/2026-0...
lazappi.id.au
Bioconductor 3.23 wrap-up – lazappi
My wrap-up of the Bioconductor 3.23 release
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Luke Zappia @lazappi.bsky.social · 12/05/2026
My quick wrap up of the recent @bioconductor.bsky.social 3.23 release focusing on single-cell and other things I'm interested in lazappi.id.au/posts/2026-0...
lazappi.id.au
Bioconductor 3.23 wrap-up – lazappi
My wrap-up of the Bioconductor 3.23 release
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Reposted by Luke Zappia
Dr Di Cook @visnut.bsky.social · 17/04/2026
#rstats SSA SCV section is excited to bring a panel discussion on “where do R packages live?” May 20, 5pm AEST Sign up to join at statsoc.org.au/event-6653060 @fontikar.bsky.social
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Luke Zappia @lazappi.bsky.social · 23/04/2026
Last week I attended a SpatialData hackathon with members of the @scverse.bsky.social, @bioconductor.bsky.social and @openmicroscopy.org communities in Padua, Italy. Here is a short blog post about the experience www.data-intuitive.com/insights/blo....
data-intuitive.com
2nd SpatialData Hackathon – Data Intuitive
Frameworks, formats and Interoperability
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Maëlle Salmon @masalmon.eu · 21/04/2026
New in Git, ✨ git history ✨ (I don't mean the Git history 🫠 ) 😰 Oh shit, that old commit's message had a typo! 😌 git history reword <commit-id> 😰 Oh shit, that old commit is too big! 😌 git history split <commit-id> (to split it into two commits) github.blog/open-source/... (h/t Hugo Gruson)
github.blog
Highlights from Git 2.54
The open source Git project just released Git 2.54. Here is GitHub’s look at some of the most interesting features and changes introduced since last time.
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Surag Nair @suragnair.bsky.social · 13/04/2026
Agents for comp bio are advancing rapidly, but evals are lagging. Current benchmarks can be overly prescriptive. Full analysis vignettes are hard to verify. We introduce CompBioBench: 100 diverse, challenging, verifiable tasks. We benchmark Codex and Claude Code. biorxiv.org/content/10.6... 1/9
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Luke Zappia @lazappi.bsky.social · 07/04/2026
LaminR 📦 has been officially announced! This is a project @rcannood.bsky.social and I have worked on to create an R client for @laminlabs.bsky.social. 📦 Repo github.com/laminlabs/la... Announcement blog blog.lamin.ai/intro-to-lam... DI blog www.data-intuitive.com/insights/blo...
github.com
GitHub - laminlabs/laminr: An R package for working with LaminDB instances.
An R package for working with LaminDB instances. Contribute to laminlabs/laminr development by creating an account on GitHub.
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Dr. Jean Fan @jef.works · 25/02/2026
We previously showed how changing training data alone can improve deep learning prediction of spatial transcriptomics gene expression from histology images by +38% (without any changes to model architecture). We've now updated our preprint w/ expanded results: www.biorxiv.org/content/10.1... 🧵1/n
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Luke Zappia @lazappi.bsky.social · 17/02/2026
Nice blog post from @thomas-sandmann.genomic.social.ap.brid.gy testing out {anndataR} 📦 tomsing1.github.io/blog/posts/a... 🎉! Cool to see people trying it out, find it on @bioconductor.bsky.social if you want to give it a go bioconductor.org/packages//re...
tomsing1.github.io
anndataR: converting single-cell data, from R to python and back – Thomas Sandmann’s blog
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Luke Zappia @lazappi.bsky.social · 05/02/2026
If you work with Docker a lot, here is your friendly reminder to occasionally run `docker system prune`. I just freed up 417 GB so I have space to work again 🗑️.
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Luke Zappia @lazappi.bsky.social · 23/01/2026
I'll been at #FOG2026 in London next week 🧬. If you are attending and want to have a chat feel free to get in touch 🗣️.
Festival of genomics social media banner showing I am attending
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Andrew Heiss @andrew.heiss.phd · 13/01/2026
This was fun! I just posted all the links and resources we talked about at www.andrewheiss.com/blog/2026/01... - check it out to learn more about Raycast, Espanso, and neat Positron/VS Code extensions like Peacock and Pastum and Project Manager #rstats #databs
andrewheiss.com
How to make your data analysis life easier using Positron, Raycast, and Espanso | Andrew Heiss
Links and resources from my time on Posit’s Data Science Lab in January 2026
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James Bonfield @jbonfield.bsky.social · 15/09/2025
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned
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Stephen Turner @stephenturner.us · 29/08/2025
anndataR enables seamless R-Python interoperability for single-cell RNA-seq by reading, writing, and converting H5AD files, supporting Seurat and SingleCellExperiment formats www.biorxiv.org/content/10.1... 🧬🖥️🧪 #Rstats github.com/scverse/annd...
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Louise Deconinck @louisedck.bsky.social · 25/08/2025
A very big thank you to all co-authors and collaborators! @lazappi.bsky.social @rcannood.bsky.social Martin Morgan @scverse.bsky.social @ivirshup.bsky.social Chananchida Sang-aram Danila Bredikhin Brian Schilder Ruth Seurinck @yvansaeys.bsky.social @saeyslab.bsky.social
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Luke Zappia @lazappi.bsky.social · 26/08/2025
It's taken more than 2 years but we can officially announce anndataR! There's still a lot of features to add but we hope a robust, "official", R-native H5AD reader/writer will unlock the defacto single-cell storage format for R users by avoiding issues with current solutions like zellkonverter.
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Louise Deconinck @louisedck.bsky.social · 25/08/2025
We're excited to share that our preprint on anndataR, a new package bringing Python's AnnData to R, is now available on bioRxiv 🎉 🔗 Read the paper: www.biorxiv.org/content/10.1... 💻 Check the package in action: anndatar.data-intuitive.com
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 17/06/2025
This week in my graduate-level Science Communication course, we are discussing communicating science to the public through public speaking (i.e., museum "evening with a scientist" nights, Nerd Nite lectures, speaking at community events, etc). What advice do you have to share with my students? 🧪
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Michael Love @mikelove.bsky.social · 30/05/2025
Bioconductor moving to Zulip for community chat stat.ethz.ch/pipermail/bi...
stat.ethz.ch
[Bioc-devel] Bioconductor is moving from Slack to Zulip – 2 June
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Marnie Blewitt @marnieblewitt.bsky.social · 14/05/2025
www.wehi.edu.au/careers/make... WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
wehi.edu.au
Make your future Melbourne | WEHI
Lead the next wave of biomedical discovery
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Lisa Sikkema @lisasikkema.bsky.social · 03/06/2025
Analyzing your single-cell data by mapping to a reference atlas? Then how do you know the mapping actually worked, and you’re not analyzing mapping-induced artifacts? We developed mapQC, a mapping evaluation tool www.biorxiv.org/content/10.1... from the ‪@fabiantheis lab. Let’s dive in🧵
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Matthias Stahl @higsch.com · 27/05/2025
We digitized the AfD report of the Federal Office for the Protection of the Constitution. This (secret) document was created to deliver proofs for the party‘s extreme right nature. Now you can explore it interactively. ➡️ 🎁 🇩🇪 www.spiegel.de/politik/deut...
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Yvan Saeys @yvansaeys.bsky.social · 01/05/2025
🔥 Just published! Thrilled to share that our work on funkyheatmap has just been published in the Journal of Open Source Software 🎉
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khrovatin.bsky.social @khrovatin.bsky.social · 28/04/2025
There is no reason to stay bound to one programming language. I discussed ways to ease R-Python interoperability with Luke Zappia, Philipp Angerer, Tomasz Kalinowski. Their tips and tricks are collected in this blog: hrovatin.github.io/posts/r_pyth... @lazappi.bsky.social @t-kalinowski.bsky.social
hrovatin.github.io
From R to Python with minimal baggage
Getting the best of both worlds.
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Luke Zappia @lazappi.bsky.social · 18/03/2025
Our paper benchmarking feature selection for scRNA-seq integration and reference usage is out now www.nature.com/articles/s41...! Keep reading for more about how we did the study and what we found out 🧵 👇 1/16
nature.com
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Philipp Bayer @philippbayer.bsky.social · 17/03/2025
We're hiring for a bioinformatics lead at the OceanOmics Centre! L7, come work with all of the cool genomics data! HiFi, HiC, Illumina, a PromethION, it's all there. Sequence *all* of the marine vertebrates! #bioinformatics external.jobs.uwa.edu.au/cw/en/job/51...
external.jobs.uwa.edu.au
Prospective staff : Jobs at UWA : IN DEVELOPMENT
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Luke Zappia @lazappi.bsky.social · 18/03/2025
Our paper benchmarking feature selection for scRNA-seq integration and reference usage is out now www.nature.com/articles/s41...! Keep reading for more about how we did the study and what we found out 🧵 👇 1/16
nature.com
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Leander @le-and-er.bsky.social · 21/02/2025
🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨 Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids. @mpi-psychiatry.bsky.social @drcricru.bsky.social 🧵👇
science.org
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
Chronic exposure to glucocorticoids during brain development leads to priming of the inhibitory neuron lineages in organoids.
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Luke Zappia @lazappi.bsky.social · 13/02/2025
Do any #rstats reticulate experts have examples of using register_module_help_handler() or register_help_topics()? I feel like these should be able to let a package provide access to help information but there isn't much documentation on how to use them.
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Will Macnair @willmacnair.bsky.social · 12/02/2025
Thought for computational biologists choosing projects: If you’re interested in method development, one counterintuitive strategy can be to dive deep into biology.
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Constantin Ahlmann-Eltze @const-ae.bsky.social · 12/02/2025
I just uploaded the first version of {{exactplot}} to github.com/const-ae/exa... 🎉 It produces figures with consistent font size, Latex labels, and millimeter-perfect layouting. It's an alternative to patchwork with less elegant syntax but much more flexibility. #rstats
Plot produced with exactplotxp_compose_plots(
  xp_text("Welcome to \\texttt{exactplot} with \\LaTeX{} support", x = 1, y = 2, 
          fontsize = xp$fontsize_large, fontface = "bold"),
  xp_text("A) Flipper length vs.\\ beak size", x = 1, y = 8),
  xp_plot(scatter_plot, x = 0, y = 12, width = 80, height = 40),
  
  xp_text("B) Beak sizes", x = 84, y = 8),
  xp_plot(beak_lengths, x = 82, y = 12, width = 58, height = 40),
  xp_text(density_formula, x = 99, y = 12, fontsize = xp$fontsize_small),
  
  width = 140, height = 52,
  keep_tex_file = FALSE, filename = "example.pdf"
)
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Oz Single Cell @ozsinglecell.bsky.social · 30/01/2025
Check out our speakers for #ozsinglecell25. May 21-23, Sydney Registrations opening soon www.ozsinglecell.com
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Lukas Heumos @lukasheumos.bsky.social · 17/01/2025
I am Stoked about our upcoming @scverse.bsky.social and @owkin.bsky.social hackathon, focused on spatial omics data analysis. 📅 March 17-19, 2025 📍 Owkin office, Paris Apply now: docs.google.com/forms/d/e/1F...
docs.google.com
Scverse x Owkin Hackathon in Paris
We're pleased to announce the next Scverse Hackathon will take place in the Owkin offices in Paris from 17/03/2025 9am to 19/03/2025 1:30pm. This hackathon is a joint initiative between the scverse c...
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Adrian Liston @labliston.bsky.social · 14/01/2025
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11 wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org
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Oz Single Cell @ozsinglecell.bsky.social · 07/01/2025
We are here 🦋. Save the date for Oz Single Cell 2025, 23-25 May in Sydney
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Cancer Bioinformatics Australia @cancerbioinfoau.bsky.social · 15/12/2024
Save the Date for Cancer Bioinformatics Australia '25! The 2nd CBA will be in Sydney on June 18th 2025. Planning is well under way, with invited speakers including but not limited to @jwhwong.bsky.social and @nadia-davidson.bsky.social See cancerbioinformatics.au for info and updates.
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Lisa Sikkema @lisasikkema.bsky.social · 13/12/2024
1/7 Planning to build a single-cell atlas? Or wondering how atlases can be useful to your research? Read our guide on single-cell atlases www.nature.com/articles/s41... published in Nature Methods, by @lisasikkema.bsky.social, @khrovatin.bsky.social, Malte Luecken, @fabiantheis.bsky.social et al.
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khrovatin.bsky.social @khrovatin.bsky.social · 16/12/2024
To bring to light data science topics that usually don’t make it into publications I started a blog on this topic: hrovatin.github.io By interviewing different researchers, I plan to find out what is going on in the community.
hrovatin.github.io
Karin Hrovatin
Data science blog on topics that don’t get published.
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Davis McCarthy @davisjmcc.bsky.social · 10/12/2024
Have you been thinking hard about statistical modelling of scATAC-seq data? (No.) Luckily for you, @aaronkwc.bsky.social has! Aaron will help you grok: What's going on? What is TF-IDF? Is there really single-cell level chromatin information? Check it out 👇 www.biorxiv.org/content/10.1... 🧪🧬💻
biorxiv.org
Going beyond cell clustering and feature aggregation: Is there single cell level information in single-cell ATAC-seq data?
Single-cell Assay for Transposase Accessible Chromatin with sequencing (scATAC-seq) has become a widely used method for investigating chromatin accessibility at single-cell resolution. However, the re...
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Rachel Thomas @math-rachel.bsky.social · 03/12/2024
Biology is *spatiotemporal* Processes such as cancer, wound healing, & embryonic development occur in both time AND space. @shazanfar.bsky.social 5/
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Rachel Thomas @math-rachel.bsky.social · 03/12/2024
You need to be careful with how you approach library size normalisation in spatial txomics, or what you could end up eliminating organs / meaningful structures. -- Dharmesh Bhuva 2/
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Dr Andrew Lonsdale @lonsbio.bsky.social · 27/11/2024
My #pyconau talk on those side project(s) that keep on giving is up! As I (almost) end with, contributions to fastqe.com and biomojify are always welcome! 🥑 🧀 🍇 🍅 💀 💩 🚨 🙂 😍 www.youtube.com/watch?v=E3-A...
youtube.com
How I Used Python to Stop Worrying & Love Emoji in Bioinformatics
YouTube video by PyCon AU
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Leander @le-and-er.bsky.social · 21/11/2024
Super excited to share our Human Neural Organoid Atlas, now out in Nature! Led by @zhisonghe.bsky.social @josch1.bsky.social, and myself, this resource was created from 36 scRNA-seq datasets—totalling over 1.7 million cells! 🔬✨
 www.nature.com/articles/s41...
 Find out how it can serve you ⏬
 🧵1/8
nature.com
An integrated transcriptomic cell atlas of human neural organoids - Nature
A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...
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Dr Andrew Lonsdale @lonsbio.bsky.social · 18/11/2024
Hive mind of 🧬 🖥️ - I am looking for one or two small data sets/repo that has a nice collection of bioinformatics file formats, e.g. a sample FASTA, FASTQ, VCF , GFF etc. They can be related experiments/organisms or disparate.
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Lukas Heumos @lukasheumos.bsky.social · 18/11/2024
I am stoked to see our EHR framework ehrapy (github.com/theislab/ehr...) being the cover of the most recent Nature Medicine issue. We consider ehrapy a MVP for a much grander ecosystem for EHR analysis like we have for single-cell data (@scverse). Read more: www.nature.com/articles/s41...
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Artur Szałata @chatgtp.bsky.social · 15/11/2024
Interested in predicting transcriptomic effects of perturbations? Check out our @NeurIPS24 D&B spotlight living perturbation prediction benchmark & new drug perturbation dataset: - paper: openreview.net/forum?id=WTI... ! - benchmarking platform: openproblems.bio/results/pert... 🧵1/8
openreview.net
A benchmark for prediction of transcriptomic responses to chemical...
Single-cell transcriptomics has revolutionized our understanding of cellular heterogeneity and drug perturbation effects. However, its high cost and the vast chemical space of potential drugs...
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Will Macnair @willmacnair.bsky.social · 14/11/2024
I made a bot that posts pre-prints of single cell papers: @prepub-singlecell.bsky.social (I posted about it a little while ago when no one was here, so posting again now :D) It's pretty dumb so very open to suggestions for improvements!
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