Abstract. The resurgence of targeted covalent inhibitors (TCIs) has expanded the diversity of electrophilic warheads used in drug discovery. TCIs must bala

A mild, modular approach to adding bicyclobutanes could bring more selectivity to these therapies

UVic researcher and associate professor David Leitch is inventing new chemistry to create drugs and medicines more efficiently and with less waste.

Marcus passed away on July 16. He was 102.

ONC is seeking a passionate and experienced leader and ocean science expert to drive the development and delivery of ONC’s Science division.

ALT: Man Washing Car with Pink Bucket

The route and process for the penultimate intermediate toward an mTOR inhibitor GSK332 in GSK’s respiratory portfolio is described. It relies on a heterocycle formation from a crystalline sodium ketoester enolate and an amidine derived from Pd-catalyzed cyanation of an azaindole. The final step involves an SNAr reaction through selective activation by a hindered sulfonyl chloride and Lewis acid activation to accelerate the rate.

Alt: Homer Obeys Laws of Thermodynamics

YouTube video by Tlili Achref

YouTube video by Internet Today

The ring-opening polymerization (ROP) of δ-lactones derived from the telomerization of CO2 and butadiene offers a platform to valorize cheap and abundant waste products into commercially competitive p...

Here’s how the new tetrahedron-based design for the “Trionda” soccer ball may affect next year’s big game

Alt: The Simpsons: Worker And Parasite Cartoon

NEW YORK—Warning that millions of men aged 35 and older would be left utterly adrift following the traumatic loss, researchers at Columbia University published a study Monday that revealed the majorit...