Carbon–carbon (C–C) coupling reactions are fundamental transformations in modern synthetic chemistry that are traditionally dominated by platinum group metal (PGM) catalysts. The scarcity, cost and toxicity of PGMs have inspired the quest for more ...

Ligand-to-metal charge transfer (LMCT) photocatalysts have emerged as powerful tools for photoredox catalysis, but the photophysics underlying their reactivity is still underexplored. Of particular in...

Conformational strain, the energy a ligand pays to adopt its bound conformation, contributes to binding affinity but is routinely misestimated. The standard estimate references a single gasphase energ...

Arenes are fundamental structural motifs in organic molecules; therefore, methods for introducing aromatic rings are of broad importance. Traditional approaches that install arenes early followed by postfunctionalization often struggle to achieve diverse ...

Drug discovery is a dauntingly difficult process due to the enormous space of possible molecules and the complexity of biological systems. Traditional in silico drug design methods have focused primarily on optimising chemical properties, often ...

Recent interest in ligand-to-metal charge transfer photocatalysts (LMCT PCs), which generate radical species upon photoinduced bond homolysis, has manifested in a variety of chemical transformations l...

Molecules showing magnetic memory effects at high temperatures could be used in high-density data storage devices. A magnetic hysteresis temperature (TH) of 100 K has been achieved for a near-linear d...

The insertion of carbon dioxide into rare earth metal-phosphorus bonds is underexplored compared to many other rare earth metal-ligand σ-bonds. Treatment of a C6D6 solution of the dimeric yttrium bis(...

A significant barrier in translating biological insights into therapeutic targets is the limited availability of high-quality chemical probes for target validation. Chemoproteomic profiling of covalent small molecules has dramatically accelerated the ...

Fused cyclopropanes are prominent motifs in bio-active molecules, yet their incorporation into densely functionalized frameworks remains a significant synthetic challenge. Herein, we report a light-mediated dearomative cyclopropanation of ben-...

The rich chemistry of molecular framework materials allows for precise control of physicochemical properties by structural design of the framework topology and the underlying building blocks. In this contribution, we demonstrate for the first time the ...

The chemistry of the classical uranium(III) complex [U(N′′)3] (N′′ = {N(SiMe3)2}–) is well-developed, but there have been surprisingly few studies of its reactivity towards N-heterocycles. Here we report the separate reactions of [U(N′′)3] with pyrazine, ...

Covalent chemical probes are powerful tools for protein profiling and inhibitor development, but their synthesis often poses significant challenges. Here, we introduce chlorotriazine (ClTriZ) as a novel covalent warhead that enables efficient and modular ...