iiinova — where your digital self keeps evolving

Jason Wong

@jwhwong.bsky.social

179 followers 289 following 12 posts

Professor at the School of Biomedical Sciences, University of Hong Kong. Uses genomics data to understand DNA repair and cancer.

Posts Replies Media

Jason Wong @jwhwong.bsky.social · 28/05/2025

Now out at #jbiolchem www.sciencedirect.com/science/arti...

sciencedirect.com

A tumor necrosis factor-α–responsive cryptic promoter drives overexpression of the human endogenous retrovirus ERVK-7

Endogenous retroviruses (ERVs) shape human genome functionality and influence disease pathogenesis, including cancer. ERVK-7, a significant ERV, acts …

073

Reposted by Jason Wong

Yuanhua Huang @yuanhuahuang.bsky.social · 02/04/2025

Our full-day mini AI hackathon on genomic language models starts soon: 8.30am-8.30pm! With a whole team, we aim to test how gLMs work for two tasks: 1. SNP2GEX: personal variants to gene expression (unseen individuals & genes); 2. Seq2CellxTF: short regulatory to TF binding (unseen cell & TFs).

152

Jason Wong @jwhwong.bsky.social · 27/03/2025

Great to finally see LocusMasterTE in print by PhD student, Sojung Lee. We developed a bioinformatics method to leverage long read sequencing data to improve expression quantification of transposable elements genomebiology.biomedcentral.com/articles/10.... #GenomeBiology

genomebiology.biomedcentral.com

LocusMasterTE: integrating long-read RNA sequencing improves locus-specific quantification of transposable element expression - Genome Biology

Transposable elements (TEs) can influence human diseases by disrupting genome integrity, yet their quantification has been challenging due to the repetitive nature of these sequences across the genome...

1198

Jason Wong @jwhwong.bsky.social · 17/03/2025

First post on Bluesky 🦋. Happy to share some new work on the epigenetic regulation of a human endogenous retrovirus (HERV) in cancer. @biorxivpreprint.bsky.social bsky.app/profile/bior... 🧵 (1/n)

110