Sign in

Kyle MacQuarrie MD PhD

@kylemacquarrie.bsky.social
3.5K followers 777 following 862 posts

Pediatric oncologist and physician-scientist in Chicago, Asst Prof, big ol’ science nerd, 🏳️‍🌈, views my own, etc etc

PostsRepliesMedia
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 7h
static.klipy.com
Leonard Geist: You Need To Learn To Read A Room
ALT: Leonard Geist: You Need To Learn To Read A Room
110
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 28/09/2026
It’s the last days of Childhood Cancer Awareness Month, and our fundraising with Alex’s Lemonade Stand Foundation will soon be coming to an end. Anything from donations, to reposts, to supporting another peds cancer effort is much appreciated! www.alexslemonade.org/2026/macquar...
alexslemonade.org
MacQuarrie Lab
Every day, there are almost 800 new cases of childhood cancer around the world. This adds up to an estimated 300,000 new cases of cancer that affect children under the age of 20 each year worldwide. A...
083
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 26/09/2026
There are worse places to do some work on the weekend.
A dog, a deck, some plants, and a real nice day, all around me while I do some work on my laptop.
020
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 25/09/2026
Initially read this as physically defending.
static.klipy.com
Highlander: There Can Be Only One
ALT: Highlander: There Can Be Only One
120
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 25/09/2026
Fortunately, I dodged.
static.klipy.com
Kids Toy Car Oops! Funny Meme
ALT: Kids Toy Car Oops! Funny Meme
060
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 25/09/2026
And to be clear - this was *inside* a building.
1140
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 25/09/2026
Still honored/traumatized about the incident where a Nobel laureate nearly ran me over with his bike.
280
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 25/09/2026
Captain Picard clutching his pearls in shock
000
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/09/2026
It was…suboptimal.
011
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/09/2026
And a thank you to Genes & Development @genesdev.bsky.social for giving me the (last clean) shirt that finally carried me through to making it all the way to home.
Me, finally at home, in a Genes & Development t shirt
030
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/09/2026
A special mention to the part where the hotel was filled with a huge party of children playing hockey in the halls and ding dong ditching doors, and the delay that was due to someone falling off an airport catering truck onto the runway. (And hope that person is ok!)
111
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/09/2026
TFW your trip home goes from JFK -> ORD to JFK -> Cleveland -> ORD to JFK -> Cleveland (delayed x2) -> ORD to JFK -> Rochester NY (inflight diversion) to JFK -> Rochester Holiday Inn (x9 hours) to RCH (+1 day) -> ORD to RCH (+1 day) -> ORD (delay x1).
220
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 19/09/2026
Ohhhh, I’m sure keeping deer in our research building basement in downtown Chicago would be super easy! Research safety would love it. 😂 (And carcinogens are one idea, but I wonder what happens when you express oncogenic gene fusions in them.)
010
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 19/09/2026
Wait, what?? I 100% did not know this. Cannot wait to tell my lab they’ll all need to get trained in handling deer.
110
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 19/09/2026
I guess I do science with the deer and in the woods now. (Partially because my flight home got cancelled literally as I posted this.)
Me, in front of a field and woods.A deer that is really very close to me
130
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 18/09/2026
Free to eat as much prepackaged salad as they please.
010
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 18/09/2026
Don’t you enjoy saying you’re ’thrilled’ and ‘honored to announce’ about things on LinkedIn though?
110
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 17/09/2026
And note to self: don’t try to snap pics of deer while jogging - it just makes it look like I’m in the Blair Witch Project.
A poor picture of deer in the distance that  looks like a still from a horror film.
010
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 17/09/2026
100% more deer content at this meeting at Cold Spring Harbor than any other scientific meeting I’ve been to.
A deer at a close distance to me.
130
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 15/09/2026
The views at Cold Spring Harbor Lab meetings just never miss. @cshlmeetings.bsky.social
One gorgeous view of a field and treesA second gorgeous view of a field and trees.
021
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 15/09/2026
I always appreciate some good canine side-eye.
A corgi on a deck giving side eye
020
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 15/09/2026
I would consider myself to be at the height of my career if I got to be interviewed by her.
010
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 12/09/2026
Sticky little handprints are going to show up on these PERFECTLY.
150
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 09/09/2026
When has a meeting-based oatmeal raisin cookie ever been a GOOD example of one, though??
120
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 09/09/2026
As long as they weren’t oatmeal raisin.
120
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 09/09/2026
@manneresearch.bsky.social
000
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 09/09/2026
Got to show up on FOX32 Chicago on Labor Day to talk about Childhood Cancer Awareness Month, how important it is to support pediatric cancer patients and families, and a little about my work. Unknowingly coordinating my tie with the anchor’s outfit was just an added bonus.
Me, smiling in a green room with the ‘FOX32 Chicago’ sign on the wall behind.A picture of a tv screen showing myself and a FOX32 anchor, Tia Ewing, talking on set about Childhood Cancer Awareness Month.
120
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 07/09/2026
Worse for you, better for amusement value.
010
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 07/09/2026
Please tell me it was either handwritten or composed on a typewriter.
110
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 03/09/2026
Too many writing tasks to get through? Do what I (accidentally) did and write the list somewhere where visitors to your office will lean against the wall and unknowingly erase them for you. Problem solved. Follow me for more efficiency tips!
A list labeled ‘writing tasks’ on a wall that has had all the items smudged out.
000
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 02/09/2026
It’s Childhood Cancer Awareness Month, and we’re taking part in Alex’s Lemonade Million Mile Fundraiser. Please consider supporting pediatric cancer patients, families, and research this month! www.alexslemonade.org/2026/macquar...
alexslemonade.org
MacQuarrie Lab
Every day, there are almost 800 new cases of childhood cancer around the world. This adds up to an estimated 300,000 new cases of cancer that affect children under the age of 20 each year worldwide. A...
030
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 31/08/2026
static.klipy.com
David Rose from Schitt's Creek
ALT: David Rose from Schitt's Creek
100
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 29/08/2026
*Very* excited to say that I and my lab are part of GENIE!
030
Reposted by Kyle MacQuarrie MD PhD
@PhysGenCenter @physgencenter.bsky.social · 14/08/2026
Just published in Advanced Science: "Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States" "We may soon be able to engineer chromatin packing states to influence cell function” postdoctoral fellow Cody Dunton said. www.mccormick.northwestern.edu/news/article...
mccormick.northwestern.edu
Study Reveals New Way Cells Organize Their Genomes
Professor Vadim Backman’s group showed that changing the nucleus’s ionic environment can rapidly reshape chromatin and alter how cancer cells respond to chemotherapy.
152
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 27/08/2026
This feels like a line from Amy Sedaris (said admiringly).
110
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 26/08/2026
Ok, even leaving the content aside (🫩), I can’t get over the fact that the first paragraph there is just one giant run-on sentence. It’s just giving breathless, frantic rant.
010
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 26/08/2026
Especially given the actual group message content was just a picture of their dog in doggles with no explanation.
000
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 26/08/2026
Shoutout to my mom yesterday turning the text she wanted to send about canine physical therapy into a new phone contact (with the text as the contact name) and then creating a new family group chat with it included.
100
Reposted by Kyle MacQuarrie MD PhD
Microplastics Sommelier @leastactionhero.bsky.social · 25/08/2026
RIP to a legend
rob dubbin @robdubbin

MY MAN: (comes home)
ME: (nervous) how was the store
MY MAN: fine
ME: oh thank g-
MY MAN: ran into jolene
ME: oh no
MY MAN: she mentioned you left kind of an intense voicemail

12:50 AM • Jul 29, 2019
9104571948
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 25/08/2026
I swear I got an invite to publish in the exact same one a few weeks ago. 😬
110
Reposted by Kyle MacQuarrie MD PhD
Phil Lewis @phillewis.bsky.social · 25/08/2026
Two people have died in Pennsylvania from measles, the state health department said. Both were unvaccinated. These the first deaths related to measles within the state in 35 years, it reports
abcnews.com
2 people die from measles in Pennsylvania
Two people have died in Pennsylvania from measles, the state health department said Tuesday.
20229441354
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/08/2026
Now that I know ‘expensive tastes’ is a keyword you can use, all my papers with pricey sequencing library prep are getting labeled this.
020
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/08/2026
The ‘I’ was unintentional but sort of works, so 🤷‍♂️
011
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/08/2026
I
static.klipy.com
Homer Simpson's Monkey Brain
ALT: Homer Simpson's Monkey Brain
120
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/08/2026
static.klipy.com
Man Giving Thumbs Down at Baseball Game
ALT: Man Giving Thumbs Down at Baseball Game
150
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 21/08/2026
Sprayed red-hot sparks out from your waist?
150
Reposted by Kyle MacQuarrie MD PhD
Med - a Cell Press journal @cp-med.bsky.social · 21/08/2026
Online Now: Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy
dlvr.it
Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy
Knight et al. present the first molecularly validated case of metastatic melanoma that divergently evolved into rhabdomyosarcoma under treatment with immune checkpoint inhibitor. Longitudinal multiomic profiling revealed that this divergence was characterized by transcriptional changes rather than genetic mutations, providing insights into the mechanisms of lineage plasticity.
021
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/08/2026
Corgi in front of a burning pyre on a lake with the caption ‘peace was never an option.’
000
Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/08/2026
You’re right, LinkedIn, I *haven’t* calculated the cost per wear of putting my lab members into these uniforms to do science. 🤔🤔 (And I guess waiters don’t exist?)
A LinkedIn ad for ‘waitressville’ uniforms.
020
Reposted by Kyle MacQuarrie MD PhD
NEJM.org @nejm.org · 19/08/2026
In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of complete remission at 200 days. Full case details: nej.md/3U8jVl2
A graph showing the change in the diameter of respective target lesions measured according to Response Evaluation Criteria in Solid Tumors, version 1.1, which documents pseudoprogression in liver metastases.
063