ALT: a close up of a white axolotl with pink ears standing on a rock .

Quiescence is a state in which cells undergo a prolonged proliferative arrest while maintaining their capacity to reenter the cell cycle. Here, we analyze entry and exit from quiescence, focusing on h...

The continued development of high-dimensional CRISPR screen readouts, such as single-cell RNA sequencing and high-content imaging, necessitates compact libraries to enable functional interrogation at ...

The inability of most human organs to regenerate themselves after injury underlies the lifelong morbidity of numerous diseases. As we continue to seek solutions for these intractable conditions, the l...

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Naqvi et al. reveal how DNA sequence determines the chromatin response to transcription factor (TF) dosage changes. By combining deep learning and chemical genetics, they uncover specific sequence fea...

Genome-wide CRISPR screening in the organism has tremendous potential to answer long-standing questions of physiology and disease; however, technical limitations have prevented its broad application. ...

Nature Communications - Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP...

Night Science · Episode

Recent Ivy League dramas have made women leaders in academia wonder how far they’ve really come.