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Sahin Naqvi

@sahinnaqvi.bsky.social
309 followers 165 following 14 posts

Studying how transcription factor dosage is utilized in development and perturbed in disease. Faculty at Boston Children’s Hospital/Harvard Medical School. naqvilab.org

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Sahin Naqvi @sahinnaqvi.bsky.social · 20/02/2026
We are looking for two exceptional Research Assistants! 1) Experimental, to drive forward quantitative studies of transcription factor function in development 2) computational, to develop and apply cutting-edge deep learning models of gene regulation. Links below
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Sahin Naqvi @sahinnaqvi.bsky.social · 27/02/2025
Excited to share the peer-reviewed version of our paper on predicting the chromatin response to TF dosage using transfer learning www.cell.com/cell-genomic...
cell.com
Transfer learning reveals sequence determinants of the quantitative response to transcription factor dosage
Naqvi et al. reveal how DNA sequence determines the chromatin response to transcription factor (TF) dosage changes. By combining deep learning and chemical genetics, they uncover specific sequence fea...
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Reposted by Sahin Naqvi
Seungsoo Kim @seungsookim.bsky.social · 20/01/2025
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org
sskimlab.org
Kim Lab at UC Irvine
Visit the post for more.
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Reposted by Sahin Naqvi
Anshul Kundaje @anshulkundaje.bsky.social · 25/12/2024
Our ChromBPNet preprint out! www.biorxiv.org/content/10.1... Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
biorxiv.org
ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants
Despite extensive mapping of cis-regulatory elements (cREs) across cellular contexts with chromatin accessibility assays, the sequence syntax and genetic variants that regulate transcription factor (T...
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Reposted by Sahin Naqvi
Vijay Ramani @vram142.bsky.social · 15/11/2024
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
cell.com
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...
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Sahin Naqvi @sahinnaqvi.bsky.social · 31/01/2024
Exciting update: we have a lab website! naqvilab.org Stay tuned for formal ads for research assistant and postdoc positions, but please reach out in the mean time if interested in joining! Thanks to the Greene lab for the excellent lab website template
naqvilab.org
Naqvi Lab
Quantitative principles of gene regulation in development and disease. Quantitative principles of gene regulation in development and disease.
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Reposted by Sahin Naqvi
Jonathan Pritchard @jkpritch.bsky.social · 01/10/2023
I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
web.stanford.edu
An Owner's Guide to the Human Genome
An Owner's Guide to the Human Genome
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Sahin Naqvi @sahinnaqvi.bsky.social · 22/09/2023
Excited to share that I will be starting my lab as faculty at Boston Children’s Hospital and Harvard Medical School in July 2024! We will seek a quantitative understanding of gene expression control in development and resulting “tipping points” in disease. Please reach out if interested!
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Reposted by Sahin Naqvi
Tuuli Lappalainen @tuuliel.bsky.social · 13/09/2023
We're looking for a postdoc! Cool ERC-funded project digging into gene dosage variation with CRISPR+sc+computational methods. Dynamic environment at KTH / SciLifeLab Stockholm campus, plus interactions with our New York team. Apply or email for more info: kth.varbi.com/se/what:job/...
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Sahin Naqvi @sahinnaqvi.bsky.social · 13/09/2023
Excited to present our recent work on TF dosage sensitivity (www.nature.com/articles/s41...) and a sneak peak at what’s in the pipeline at the Fragile Nucleosome series, tomorrow (Wed) 9 AM PST! Register here: generegulation.org/fragile-nucl...
generegulation.org
Fragile Nucleosome – Gene Regulation – Teif Lab
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