Summary: MTFR1L acts at mitochondrial mitophagy initiation sites, linking mitochondrial fission with autophagy by interacting with ULK1, regulating ATG13 stability, and forming a feedback loop that su...

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Riccardo Bab...

CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.

Selective macroautophagy/autophagy relies on newly formed double-membrane compartments, known as phagophores, to sequester and recycle diverse cellular components, including organelles, biomolecula...

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

The clearance of biomacromolecules through selective autophagy is crucial for cellular homeostasis. A study now identifies receptor mobility as a key factor influencing cargo degradability. A dynamic ...

Nature Cell Biology - Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in...

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

Valérie Hilgers has been awarded a prestigious ERC Consolidator Grant. She will investigate how the alternative processing of RNA molecules in neurons enables the unique functions of this cell type an...