Miklas et al. characterize age-related C. elegans intestinal secretory-pathway proteins using proximity labeling tools and in vivo proteomics. They identify a conserved secreted phosphatase, ACP7, that extends lifespan in a secretion- and phosphatase-dependent manner. This resource highlights the role of extracellular enzymes in regulating lifespan.

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

Nature Cell Biology - It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders...

The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

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