Identifying off-target interactions of approved drugs is important to anticipate side effects and uncover repurposing opportunities. Computational pipelines combining structural homology, structure pr...

Nature Microbiology, Published online: 09 March 2026; doi:10.1038/s41564-026-02277-8This study highlights that Schlafens are ancient, mechanistically conserved immune effectors that mediate antiviral immunity in organisms ranging from humans to bacteria.

Kirill Medvedev's academic upbringing in Akademgorodok, Siberia, influenced his future career path, which led him to UCF.

Nature - Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

Computational Structural Biology | Cancer Bioinformatics | Digital Pathology. Medvedev Lab will open in August 2025 in the [Department of Computer Science](https://www.cs.ucf.edu/) at the [University ...

Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...

Computer approach creates synthetic enzymes 100 times more efficient than those designed by AI.

With walk-up songs, bold ideas, and a festival atmosphere, like-minded researchers band together to reshape scientific meetings.

A short bout of indulgence in fatty, sugary snacks leads to lingering brain-activity changes ― even if it does not cause weight gain.

Two journals embarked on efforts to compensate reviewers, with different results.

The structure of the orphan GPCR GPR179 bound to the extracellular matrix component pikachurin is solved.

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White House dismissals and rationale challenged by dismissed scientists and lawsuits

The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...