Experimental organisms such as the nematode Caenorhabditis elegans are fundamental to biological discovery. The success of C. elegans research has ...

Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Bayer et al. show that the DEGT-1 DEG/ENaC channel is specifically expressed in C. elegans pharyngeal neurons and localizes to the pharyngeal basement membrane. They found that DEGT-1 is required in I...

As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.

YouTube video by Morris Maduro

Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mecha...

(Cell 166, 209–221; June 30, 2016)

Perez et al. report that self-assembling nematode towers occur in nature and can function as collective dispersal structures. Using Caenorhabditis elegans, they establish a tractable empirical model t...

Bacteria encode homologs of the human NACHT proteins that form inflammasomes, and use them to defend against phage infection. This study shows that the NLR-related protein bNACHT25 detects diverse pha...

Malaria parasites survive in red blood cells by breaking down hemoglobin in their digestive vacuole (DV). This study identifies a new large anion channel, BVAC, as responsible for DV acidification, en...

The authors show that in C. elegans, Vitamin B12-driven changes in neuronal methionine cycle trigger a neuron-gut signalling axis, involving serotonin and neuropeptide secretion that modulate stress t...

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activati...

One avenue to better understand brain evolution is to map molecular patterns of evolutionary changes in neuronal cell types across entire nervous syst…

Cells reallocate their limited energy for cellular maintenance in response to nutrient scarcity at the expense of other processes, but how this trade-off is achieved remains unknown. These authors sho...

Caenorhabditis elegans FLWR-1/Flower is required for efficient synaptic vesicle recycling and does so through a functional and possibly direct physical interaction with the plasma membrane Ca2+ ATPase...

Proteins with a Toll/interleukin-1 receptor/resistance (TIR) domain are among the most ancient immune regulators and include well-known pattern recognition receptors (PRRs). A specialized subset of TI...

Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in viv...

Deviating from established protocols is the most likely reason why Gainey et al. (2024) could not reproduce earlier results in a Caenorhabditis elegans transgenerational inheritance paradigm, and the ...

In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...