Sign in

Pukkila-Worley Lab

@rpwlab.bsky.social
76 followers 19 following 4 posts

Research Scientist. Infectious Diseases Physician. Professor of Medicine. UMass Chan Medical School. Innate immunity, intestinal epithelial cells and worms.

PostsRepliesMedia
Pukkila-Worley Lab @rpwlab.bsky.social · 12/06/2025
Check out the cover of @cp-trendsimmuno.bsky.social !! Art by lab alumna Sammy Tse, highlighting our lab's review in the issue by Khursheed Wani on enzymatic TIR proteins in innate immunity!!! www.cell.com/trends/immun...
020
Pukkila-Worley Lab @rpwlab.bsky.social · 02/06/2025
Incredibly proud of Mo Nasrallah @umasschan.bsky.social MD,PhD graduate from my lab. So much fun to celebrate his accomplishments and those of his classmates this weekend. #UMassChan2025
030
Pukkila-Worley Lab @rpwlab.bsky.social · 21/05/2025
Excited to share another review from the lab, this one by @khursheed01.bsky.social, out this week in @cp-trendsimmuno.bsky.social . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! www.cell.com/trends/immun...
cell.com
Evolutionarily ancient functions of enzymatic TIR proteins in innate immunity
Proteins with a Toll/interleukin-1 receptor/resistance (TIR) domain are among the most ancient immune regulators and include well-known pattern recognition receptors (PRRs). A specialized subset of TI...
031
Pukkila-Worley Lab @rpwlab.bsky.social · 28/04/2025
In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...
nature.com
Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology
In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...
23911