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Lewsiferase

@lewsiferase.bsky.social
122 followers 154 following 12 posts

HHMI - Jane Coffin Childs Postdoctoral Fellow Evolution, biochemistry, and wherever that takes me next! Current passion: bat diarrhea 🦇💩

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Katja Kasimatis @katjakasimatis.bsky.social · 03/07/2026
First paper from the Kasimatis Lab is now online! We investigate of the maintenance of mate plugging in C. elegans along with its function www.biorxiv.org/content/10.6...
biorxiv.org
A Male Expressed Copulatory Plug Increases Female Fertility in Caenorhabditis Nematodes
The genomes of self-fertilizing hermaphrodites offer a unique opportunity to probe why some genes with sex-specific functions are lost while others are maintained. In the androdiecious species, Caenor...
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Harmit Singh Malik @harmitmalik.bsky.social · 01/07/2026
Jeremy Hollis’ detective story on centromeric histone chaperones (HJURP/Cal1) is now published after peer review with a few extra goodies. @jeremyahollis.bsky.social @nlehrbach.bsky.social @cbmoens.bsky.social @irinakitop.bsky.social @basicsci.fredhutch.org www.science.org/doi/10.1126/...
science.org
Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans
Animals encode a rapidly evolving, essential cell cycle gene previously thought to be absent.
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Noah Whiteman @nkwhiteman.bsky.social · 25/06/2026
So excited to announce our search for 4 postdocs (funded by the Simons Foundation) who will use genomics to "test how ecological interactions, natural selection, natural enemies, hybridization & environmental gradients shape...tropical tree communities" in Panama: stri.si.edu/story/bci-ev... ...1
stri.si.edu
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Tamanash Bhattacharya @tamanash.bsky.social · 17/06/2026
Thrilled to share our latest work on Sindbis virus immunity evasion, now out in @SciAdvances! www.science.org/doi/10.1126/... A single codon offers an elegant solution that outsmarts two evolutionarily distant hosts using the same strategy—viral economy at its finest. A true duel of the fates!
static.klipy.com
Liam Neeson in Star Wars Lightsaber Duel
ALT: Liam Neeson in Star Wars Lightsaber Duel
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David L. Stern @gallseeker.bsky.social · 02/04/2026
New paper from the Stern and Gronenborn labs on structure and evolution of aphid bicycle effector proteins. We show how alphafold can generate accurate predictions for these rapidly evolving proteins and that these proteins are diverse in every possible way. www.biorxiv.org/content/10.6...
biorxiv.org
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hsiehyp.bsky.social @hsiehyp.bsky.social · 17/03/2026
Hiring Alert: My lab(www.labofpie.org) is looking for BS/MS-level research assistants to study fungal-bacterial competition. Come join us if you are interested! ipmb.sinica.edu.tw/en/recruitme...
ipmb.sinica.edu.tw
IPMB | 中央研究院植物暨微生物學研究所
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hsiehyp.bsky.social @hsiehyp.bsky.social · 05/03/2026
Our story on the evolution of colistin resistance is just out on @plosbiology.org (journals.plos.org/plosbiology/... Evolution doesn’t happen in isolation. We show that competing fungi can rewire the evolutionary trajectory of colistin resistance in P. aeruginosa. Great teamwork with the Ernst lab
journals.plos.org
Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs
Bacterial resistance to the vital last-resort antibiotic colistin is an increasing challenge. This study shows that magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher l...
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Takashi Akera Lab @takashiakeralab.bsky.social · 07/02/2026
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus. www.science.org/doi/10.1126/...
science.org
Hybrid female sterility due to cohesin protection errors in mouse oocytes
Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.
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Jackson Ridges @jacksonridges.bsky.social · 11/01/2026
Check out our new paper in early access at Nature Communications! www.nature.com/articles/s41...
nature.com
Client Challenge
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Lewsiferase @lewsiferase.bsky.social · 11/01/2026
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Lewsiferase @lewsiferase.bsky.social · 06/12/2025
Another selfish element in the best worm!
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Antoine Molaro @antoinemolaro.bsky.social · 06/10/2025
Hello World! It took a minute, but much improved version (thank you peer review) of Joris paper is out @genomebiolevol.bsky.social bsky.app/profile/geno...
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Greg Copenhaver @copenhaverlab.bsky.social · 06/10/2025
The @uncchapelhill.bsky.social Department of Biology is searching for tenure-track Assistant Professor in Plant Molecular Biology. Chapel Hill is a wonderful place and Biology is an amazing group of people. To apply, see: unc.peopleadmin.com/postings/307...
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Mia Levine @levine-lab.bsky.social · 04/10/2025
Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon. We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least). authors.elsevier.com/c/1loW-3QW8S...
authors.elsevier.com
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hsiehyp.bsky.social @hsiehyp.bsky.social · 10/07/2025
Exciting news! I am launching the Lab of Polymicrobial Interaction & Evolution at IPMB at Academia Sinica (ipmb.sinica.edu.tw/en)! 🎉Our brand-new website is live: (www.labofpie.org). Check the lab of PIE out!!🥧🎈
ipmb.sinica.edu.tw
IPMB | 中央研究院植物暨微生物學研究所
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ching-hochang.bsky.social @ching-hochang.bsky.social · 11/07/2025
I’m thrilled to announce the launch of the Evolution of Chromosomes and Genomes (ECG) Lab at the Institute of Molecular Biology, Academia Sinica, Taiwan. Our lab website is now live—come check it out! sites.google.com/view/ecg-lab...
sites.google.com
ECG LAB
"The only constant in life is change." — Heraclitus Genetic conflicts — the good, the bad, and the ugly — shape our lives over time We aim to understand why even the most essential genes and chrom...
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Lewsiferase @lewsiferase.bsky.social · 25/06/2025
Absolutely stoked to be part of the JCC community! Let’s do some awesome science together!
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Piali Sengupta @senguptalab.bsky.social · 30/05/2025
9 minutes. Hah. That's 8 mins too late in the worm community.
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Sonya Widen @sonyawiden.bsky.social · 28/05/2025
@lewsiferase.bsky.social fighting the good fight to put animal toxin-antidote elements on the map! Quite jazzed to see this story published. Tag yourself, I am the transient blob #teamTAs
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Matt Rockman @wormsrock.bsky.social · 28/05/2025
Beautiful work showing how PEEL-1 gets away with murder Congrats @lewsiferase.bsky.social et al!
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PLOS Biology @plosbiology.org · 27/05/2025
#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN
Selected frames of a live-cell imaging time-course experiment. A single cell is shown, co-expressing PEEL-1::eGFP and PMPL-1::mCherry. The nucleus is labeled (“N”). t = 0 is 16 hrs after transfection. Acute swelling can be seen (t = 2 hr 30 min), followed by a transient blob or protrusion (arrow) jetted out by the cell (t = 4 hr 15 min) and later reabsorbed (dotted arrow) (t = 4 hr 20 min). Scale bar = 10 µm.
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Mia Levine @levine-lab.bsky.social · 10/11/2023
Sometimes a paper stops you in your tracks. New work from Loppin’s group found that histone eviction during sperm development ensures that paternal chromosomes aren’t mistaken for maternal chromosomes in the Drosophila embryo. My Perspective: www.science.org/doi/full/10.... 1/2
science.org
Science | AAAS
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