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United States Senate Special Committee on Aging

Recent NIH funding cuts, including overhead restrictions, are causing major concerns across the longevity and biomedical research community. We are collecting data on how these changes are affecting p...

Neuroimaging and Neuropathological Investigations of Alzheimer's Disease Clinical and Biological Heterogeneity Renaud La Joie, PhD Assistant Professor of Neurology University of California, San Franc...

Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

BIOLOGY General Science community https://go.bsky.app/HVYAMEA Research Institutions in Life Sciences https://go.bsky.app/LxXpcvJ LGBTQIA+ in STEM https://go.bsky.app/BFc4wgf LGBTQIA+ in STEM 2 h...

Pioneering women in ageing research. Photo credits: Marjory Warren, Photo: Archives of the British Geriatrics Society; Lillien Martin, courtesy of the Department of Special Collections, Stan...

Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...

Join us at the Keystone Symposia on Aging: New Frontiers in Rejuvenation and Gerotherapeutics, February 2025, in Breckenridge, with field leaders!

Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Endosomal retrieval and recycling of integral cargo proteins is essential for cell, tissue and organism-level development and homeostasis and is orchestrated through a specialised retrieval sub-domain...

Fat droplets in microglia may explain why certain genetic variants increase Alzheimer’s disease risk, NIA-funded study finds.