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A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...

Gadek et al. show that embryonal rhabdomyosarcoma formation is defined by the presence of primary cilia and limits SHH pathway competency in early endothelial progenitor cells that disappear during em...

New Faculty Opportunity – Center for Childhood Cancer Research at Nationwide Children’s Hospital

Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...

Tallan et al. report a versatile approach for highly quantitative protein-genome binding, demonstrating applications for human and zebrafish cells. The proposed PerCell methodology and analysis strate...

Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...