iiinova — where your digital self keeps evolving

Reposted by Kenneth Chen

Jack Kucinski @jackkucinski.bsky.social · 23/07/2025

I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...

cell.com

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...

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Kenneth Chen @kennethschen.bsky.social · 24/06/2025

Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...

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Kenneth Chen @kennethschen.bsky.social · 23/04/2025

Congratulations to Claudette Fraire, Kavita Desai, Indumathy Jagadeeswaran, and others, for their work showing how microRNA loss drives a mouse model of a childhood cancer called pineoblastoma! @genesdev.bsky.social genesdev.cshlp.org/cgi/content/...

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Kenneth Chen @kennethschen.bsky.social · 03/04/2025

Nice work Sun, Josh, Tu, and others!

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Reposted by Kenneth Chen

American Association for Cancer Research (AACR) @theaacr.bsky.social · 02/04/2025

How can new approaches in early detection make a difference for pediatric cancers? In the new episode Believe in Progress podcast, we speak with Dr. Kris Ann P. Schultz, a pediatric oncologist, about how research is reshaping pediatric cancer care: www.youtube.com/playlist?lis...

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Reposted by Kenneth Chen

NPR @npr.org · 23/01/2025

An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.

npr.org

National Institutes of Health cancels scientific meetings after Trump directives

An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.

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Reposted by Kenneth Chen

Our World in Data @ourworldindata.org · 09/01/2025

Childhood cancer deaths in the United States have declined six-fold over the last seventy years

This chart presents US cancer death rates in children under five years old, measured in reported annual death rates per 100,000 children. It consists of four graphs:

1. All Malignant Cancers Combined: This graph, shown in black, illustrates a decline in childhood cancer death rates from about 11 per 100,000 in 1950 to around 1.8 in 2021, indicating a six-fold decrease since the 1950s.

2. Leukemia: This graph shows a decrease from around 5 per 100,000 in 1950 to less than 1 in 2021, following a similar declining trend throughout the decades.

3. Brain and Nervous System Cancers: This chart shows some fluctuations but overall a decline from nearly 0.8 per 100,000 in 1950 to about 0.4 in 2021.

4. Lymphomas and Multiple Myeloma: This graph shows fluctuations and a decline from around 0.8 in the late 1950s to less than 0.2 by 2021.

The data is sourced from the WHO Mortality Database (2024), with a note indicating that figures may fluctuate year-by-year due to low numbers.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers? New preprint from the lab! PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor www.biorxiv.org/content/10.1...

biorxiv.org

PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor

Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD...

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Reposted by Kenneth Chen

Olivier Saulnier @olivier-saulnier.bsky.social · 24/11/2024

Let's build a starter pack for childhood cancer research. Please send a message to be added! 🎗️ go.bsky.app/Tpd9QnM

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Reposted by Kenneth Chen

Josh Mendell @mendell-lab.bsky.social · 22/11/2024

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

science.org

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

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