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Kathleen Farley

@kafarley.bsky.social
185 followers 81 following 31 posts

Discovery NMR Scientist @Pfizer #PfizerChemistry- Wife, mother, & animal lover. All posts and opinions are my own. ORCID: 0000-0001-8935-6852

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Kathleen Farley @kafarley.bsky.social · 22/09/2026
Excited to see this collaboration with Bruker BioSpin in print! @NMRchat @pubs.acs.org pubs.acs.org/amclct/artic...
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Kathleen Farley @kafarley.bsky.social · 17/09/2026
Looking forward to teaching the NMR Structure Elucidation workshop at SMASH with Ormacinda (Cindy) White in Breckenridge, CO sponsored by JEOL JASON #SMASH2026 #NMRchat
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Kathleen Farley @kafarley.bsky.social · 15/09/2026
The myth, the man, the legend! Gregory Walker presenting at SMASH this morning wrapping up a fantastic 39 year career at Pfizer! #NMRchat #SMASH2026
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Kathleen Farley @kafarley.bsky.social · 14/09/2026
One of my favorite sessions at SMASH is next- the MRC sponsored “Early Career Researchers Symposium”. #NMRchat
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Kathleen Farley @kafarley.bsky.social · 13/09/2026
Looking forward to the NMR user meetings today at SMASH 2026 in Breckenridge, CO. #NMRchat
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Eric Topol @erictopol.bsky.social · 02/09/2026
What is being done vs #LongCovid and other post-viral serious chronic illness? Not enough. www.nature.com/articles/d41...
nature.com
When do infections lead to long COVID? Scientists close in on triggers and treatments for post-viral syndromes
Hundreds of millions of people have long-term conditions as a result of an infection. Researchers are working out how to help them.
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Kathleen Farley @kafarley.bsky.social · 05/08/2026
I'm excited to be teaching a workshop on NMR Structure Elucidation with Ormacinda White at #SMASH2026 in Breckenridge, CO on Sept. 17, 2026. The workshop will focus on analyzing 1D and 2D NMR data for determining the structure of small molecules. Hope to see you there! smashnmr.org/program/ #NMRchat
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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 26/07/2026
The FDA used to have a warning on its website against bogus autism “remedies,” eg, the dangerous—sometimes deadly—chelation pushed by RFK Jr & his antivaxx ally David Geier RFK Jr ordered the warnings to be removed 😢 Anyone who tells me I must “find common cause” with MAHA & its leader can STFU
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Magnetic Resonance News @nmr900.bsky.social · 10/07/2026
Reuters, China temporarily bans helium exports as US-Iran tensions flare again www.reuters.com/world/asia-p... #NMRchat 🧲
reuters.com
China temporarily bans helium exports as US-Iran tensions flare again
China announced on Friday a temporary export ban on ​helium, effective immediately, as resumption of military conflict in ‌the Middle East threatens to trigger new shortages of the gas critical for ch...
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Kathleen Farley @kafarley.bsky.social · 09/07/2026
A walk down memory lane! I ❤️ Asilomar! #NMRchat #ENC #Bruker
Old ENC t-shirt from 1996Old ENC t-shirt from 2009Pharmacia and Upjohn t-shirt given to employees at the time of the merger.
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ACS Publications @pubs.acs.org · 22/05/2026
We're proud to announce our new webinar ‘Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’, taking place on June 3, 12:00–13:30 ET, featuring our 2026 Portoghese Lectureship Award winners. Register to attend this free event: buff.ly/GD44ZuJ
Announcing ‘Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’, part of our ‘Fueling Scientific Discovery: ACS Publications’ Celebrated Scientists’ webinar series. 

Taking place on June 3, 12:00–13:30 ET - and presented by our 2026 Portoghese Lectureship Award winners: 

🌟 Prof. Alison Axtman, UNC Chapel Hill, United States 
🌟 Prof. Fleur Ferguson, UC San Diego, United States 

Moderated by: Prof. Craig Lindsley, Editor-in-Chief, Journal of Medicinal Chemistry and Professor at Vanderbilt University, United States
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nmrguy.bsky.social @nmrguy.bsky.social · 04/05/2026
Registration and abstract submission now open for SMASH in stunning breckenridge. smashnmr.org
smashnmr.org
SMASH - Small molecule NMR conference
Small molecule NMR conference.
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Kathleen Farley @kafarley.bsky.social · 04/05/2026
Attending the opening session of the 2026 PANIC NMR meeting in Rockville, MD. #NMRchat #PANIC
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Jeff Sharlet @jeffsharlet.bsky.social · 21/04/2026
Like me, you may think you understand the horror of measles and the murder being committed by RFK & co. Read this, if you can handle it--my eyes are tearing up for this splendid child lost--and learn just how much more terrible and heartbreaking it is. www.nytimes.com/2026/04/21/o...
nytimes.com
Opinion | Measles Took My Daughter. This Is What I Want Everyone to Know.
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Nature Biotechnology @natbiotech.nature.com · 21/04/2026
NMR-as-you-go for drug hunters www.nature.com/articles/s41...
nature.com
NMR-as-you-go for drug hunters - Nature Biotechnology
Craving speed and convenience, biopharma companies turn to providers with NMR know-how.
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Blair Braverman @blairbraverman.bsky.social · 18/03/2026
It's hard to think about retiring from racing, because mushing is, and will always be, a huge part of my life. So I took a journey with my older dogs, who have retired themselves. They've taught me so much over the years; now, they're teaching me to live with change. www.nytimes.com/2026/03/18/m...
nytimes.com
‘Their Power Feels Like Mine’: A Dog Sled Racer Says Goodbye To Her Pack
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Magnetic Resonance News @nmr900.bsky.social · 08/02/2026
Pfizer Super Bowl LVIII (58) 2024 Commercial, Behind The Scenes www.youtube.com/watch?v=ZBan...
youtube.com
Pfizer "Galileo, Copernicus, Isaac Newton" and Behind The Scenes Super Bowl LVIII(58)2024 Commercial
YouTube video by Not Your Dads TV Ads
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NMR-EPR-DNP-papers @nmr-epr-dnp-papers.bsky.social · 13/01/2026
#NMRchat Efficient logP determination by automated, spatially encoded 19 F NMR Spectroscopy pubs.rsc.org/en/Content/ArticleLand…
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Lisa Jarvis @lisamjarvis.bsky.social · 07/12/2025
For my latest @opinion.bloomberg.com, I wrote about this week's ACIP meeting-- yes, the CDC panel's terrible hep B vaccine decision, but the simple strategy RFK's handpicked members are using to sow confusion and distrust in vaccines. (🎁 link)
bloomberg.com
CDC Panel’s Hepatitis B Vaccine Vote Undid Decades of Progress
In a stunning decision that defies all expert advice and scientific evidence, the influential group that shapes US vaccine policy will no longer recommend that all infants receive the hepatitis B vacc...
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Kathleen Farley @kafarley.bsky.social · 07/12/2025
@popher.bsky.social & @canklin.bsky.social Can you both please come to SMASH next fall in Breckenridge and host a wine & cheese tasting? I predict it would be the most popular workshop at the meeting! #NMR
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Magnetic Resonance News @nmr900.bsky.social · 28/11/2025
@angewandtechemie.bsky.social (open) Ultrabroadband 1D and 2D NMR Spectroscopy, corresponding Burkhard Luy @kit.edu Dedicated to Richard R. Ernst (1933–2021) onlinelibrary.wiley.com/doi/10.1002/... #NMRchat #NMR 🧲
onlinelibrary.wiley.com
Ultrabroadband 1D and 2D NMR Spectroscopy
Optimal control-derived saturation pulses allow 1D and 2D NMR spectroscopy covering spectral ranges in the MHz range. Next to a multitude of nuclei even multinuclear spectra are possible.
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Eric Topol @erictopol.bsky.social · 27/11/2025
"a debilitated CDC unable to protect the health of the American people." www.thelancet.com/journals/lan... @thelancet.com
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ACS Publications @pubs.acs.org · 19/11/2025
Seven journals are now accepting submissions through ACS Publishing Center. Together they represent over 25% of the authors who choose ACS journals to publish their best work. Learn more: buff.ly/OijMXFU
buff.ly
Improving the Author Experience: ACS Publishing Center Reaches a New Milestone
Seven journals are now accepting submissions through ACS Publishing Center. Together they represent over 25% of the authors who choose ACS journals to publish their best work.
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Kathleen Farley @kafarley.bsky.social · 31/10/2025
Make a nomination! The 2026 Philip A. Portoghese Early Career Award for the Advancement of Medicinal Chemistry recognizes two outstanding early career investigators in the field of medicinal chemistry research. The deadline for nomination is December 1, 2025. Thank you! #ACSMedChemLett #JMedChem
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Kathleen Farley @kafarley.bsky.social · 22/09/2025
SMASH 2025 is kicking off with a session on Accelerating Small Molecule Drug Innovation moderated by Daneen Angwin-Kaerner #NMR #SMASH2025
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Kathleen Farley @kafarley.bsky.social · 21/09/2025
@rrgil.bsky.social kicking off the Early Career Researcher’s Symposium sponsored by Magnetic Resonance in Chemistry (MRC) at the SMASH NMR meeting in Porto, Portugal. #Smash2025 #nmr
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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 14/09/2025
Reading today’s big NYT Magazine story made me physically sick It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research Not just the US vaccine system—they’re crushing cancer R&D 🎁Link www.nytimes.com/2025/09/14/m...
nytimes.com
How the Trump Administration Is Dismantling America’s Cancer-Research System
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Peter Gleick @petergleick.bsky.social · 18/05/2025
This is just a partial glimpse of the destruction of American science by Trump and the GOP.
Table showing the massive cuts in federal science funding for EPA- 54.5%, NASA -24%. NOAA - 24%, NSF -56%, USGS- 38% etc.
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Yolanda Perez @yolandapereznmr.bsky.social · 11/05/2025
This is no way to run a bagel shop or a country by Art Edison. #NMRchat artedison.substack.com/p/this-is-no...
artedison.substack.com
This is no way to run a bagel shop or a country
Academic science in the US is being gutted by Trump
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Science Magazine @science.org · 28/04/2025
Vaccine scientists and medical leaders have announced they are launching an unprecedented initiative to react to vaccine misinformation and scientifically unfounded vaccine decisions by the U.S. government. scim.ag/3ES9r1Q
scim.ag
Vaccine experts band together to counter U.S. government misinformation
Vaccine Integrity Project intends to provide scientific responses to ill-founded vaccine moves
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60 Minutes @60minutes.bsky.social · 28/04/2025
Nearly 800 NIH grants have been terminated so far, including some focused on HIV and AIDS, trans health, and COVID-19, after researchers were told their work was no longer an agency priority. cbsn.ws/3YkDndI
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Kathleen Farley @kafarley.bsky.social · 26/04/2025
Rainy Saturday = bread baking. Made Cuban bread for the first time. #chemistswhocook
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Eric Topol @erictopol.bsky.social · 01/04/2025
www.washingtonpost.com/health/2025/...
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Eric Topol @erictopol.bsky.social · 31/03/2025
On a letter I signed www.nytimes.com/2025/03/31/s...
nytimes.com
Trump Administration Has Begun a War on Science, Researchers Say (Gift Article)
Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.
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Philippe Lesot @philippe-lesot91.bsky.social · 05/02/2025
The #NMR event not to be missed in 2025! Poster chair committee 2025 : Kathleen Farley, Amy Freund, Roberto Gil and Philippe Lesot What a panel ! #NMRevents #NMRchat #NMR
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Kathleen Farley @kafarley.bsky.social · 01/03/2025
Proud to be a member of this team! #NMRchat pubs.acs.org/doi/10.1021/...
pubs.acs.org
Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease
In early 2020, severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infections leading to COVID-19 disease reached a global level leading to the World Health Organization (WHO) declaration of ...
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Danielle Beckman @daniellebeckman.bsky.social · 19/02/2025
Nothing else to say.
"If you think research is expensive, try disease"  - Mary Lasker
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Kathleen Farley @kafarley.bsky.social · 17/02/2025
A great example of the utility of NMR in drug discovery! Congratulations to the team! #NMRchat pubs.acs.org/doi/10.1021/...
pubs.acs.org
Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists
CCR6 is a chemokine receptor that mediates the migration of pathogenic inflammatory leukocytes to sites of inflammation in response to its ligand, CCL20. Herein we report the design of a potent CCR6 antagonist capable of inhibiting the chemotactic migration of CCR6+ T cells in vitro. Key to this finding was the discovery of a remarkable methyl substituent effect on antagonist potency. A 365-fold improvement in potency was observed for the cis-2-methylcyclohexanamine analogue compared to the unsubstituted cyclohexanamine derivative. Evidence generated through the characterization of conformationally restricted analogues supports the conclusion that the large potency enhancement is the result of the methyl substituent biasing the cyclohexane ring ground state conformation to favor that of the bound ligand and thus decreasing the ligand strain energy.
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Derek Lowe @dereklowe.bsky.social · 12/02/2025
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late. Silence gives consent. And no one should consent to this.
science.org
Stand Up And Be Counted
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Heather Thomas @heatherthomasaf.bsky.social · 09/02/2025
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Eric Topol @erictopol.bsky.social · 08/02/2025
It's not "Breaking News" now, since it was announced by NIH yesterday. But it is breaking....... washingtonpost.com/health/2025/...
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Kathleen Farley @kafarley.bsky.social · 08/02/2025
SMASH 2025 is in Porto, Portugal. #NMRchat #SMASH2025
Picture of SMASH 2025 program chairs in Porto, Portugal
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Lisa Jarvis @lisamjarvis.bsky.social · 01/02/2025
🧪 About that "gold standard science" RFK is promising...and other takeaways from his two days in the hot seat. My latest @opinion.bloomberg.com (gift link):
bloomberg.com
RFK Jr. Is Not Up to the Enormous Task Before Him
During his confirmation hearings, President Trump’s nominee to lead the Department of Health and Human Services showed that his dangerous views on vaccines and science haven’t changed.
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Lisa Jarvis @lisamjarvis.bsky.social · 24/01/2025
Some thoughts on the confusion and anxiety created by the current freeze on communications, hiring, grant reviews, travel, etc at NIH (gift link):
bloomberg.com
Trump's NIH Freeze Puts Scientific Research at Risk
America’s best scientific minds are scrambling to determine the impact of the disruption.
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Kathleen Farley @kafarley.bsky.social · 19/01/2025
As an introduction to #bluesky -I ❤️ big magnets #chemsky #nmrchat -I just retired from #pfizer after 35+ years -I am still active in NMR #SMASH @pubs.acs.org #MRC #JMedChem #consulting -I ❤️ Sourdough! #chemistswhocook -I ❤️ sled dogs #UglyDogs
Female scientist in front of NMR magnetSourdough breadSiberian husky puppy
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Eric Topol @erictopol.bsky.social · 10/01/2025
The letter signed by >15,000 physicians re: RFK Jr www.documentcloud.org/documents/25...
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Kathleen Farley @kafarley.bsky.social · 03/01/2025
My new obsession: Japanese milk bread #Chemistswhocook
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Marc A. Marti-Renom @mamartirenom.bsky.social · 31/12/2024
I heard today the sad news that Martin Karplus passed away. He was 94 (I believe). I had the great privilege to work with him during my PhD and can say he was great! RIP Martin. 😔
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Mohamed Sabba @sabba.bsky.social · 28/12/2024
Fun fact: the "Knill pulse"; perhaps the most well-known composite pulse in quantum information science - popularized by Ryan, Hodges & Cory¹ in 2010, attributed to Emanuel Knill - was actually first described by Tycko & Pines² in 1984. #nmrchat ¹ doi.org/10.1103/Phys... ² doi.org/10.1016/0009...
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Magnetic Resonance News @nmr900.bsky.social · 24/12/2024
NMR Wayback Machine: Let's get acquainted! The entire collection of Barry Shapiro’s NMR Newsletters (1958-2001) is now available online. A big thank-you to Clemens Anklin @canklin.bsky.social for making this possible! ismar.org/barry-shapir... #NMRchat #NMRnews #NMR 🧲
Barry Shapiro’s NMR Newsletters
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