Sign in

Tristan Shuman

@tristanshuman.bsky.social
1.7K followers 905 following 22 posts

Neuroscientist studying memory, epilepsy, and Alzheimer’s disease. Associate Professor at Icahn School of Medicine at Mount Sinai

PostsRepliesMedia
Tristan Shuman @tristanshuman.bsky.social · 20/05/2026
Apply for our Paris Miniscope Workshop this summer: July 1-3, 2026. Come learn to record and analyze calcium imaging data with open source Miniscopes! Applications due this Friday May 22. Apply here: docs.google.com/forms/d/e/1F...
docs.google.com
2026 Paris Miniscope Workshop Application
We're excited to invite applications for the 2026 Paris Miniscope Workshop, hosted at ESPCI Paris and organized by Daniel Aharoni (UCLA), Denise Cai and Tristan Shuman (Icahn School of Medicine Mount ...
01010
Reposted by Tristan Shuman
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 17/11/2025
Reunion with past and present Cai lab & Shuman lab members (and collaborators). Spending time with you guys is easily the best part of my job. @tristanshuman.bsky.social @sinaibrain.bsky.social @sfn.org
0165
Tristan Shuman @tristanshuman.bsky.social · 14/11/2025
If you are at SFN this week come to our SFN dance party! Monday night at Parq nightclub. Open to everyone. @denisejcai.bsky.social, Kay Tye, and I are giving out VIP bracelets at SFN all weekend!
0110
Reposted by Tristan Shuman
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 20/10/2025
See you on the dance floor! @tristanshuman.bsky.social
0222
Reposted by Tristan Shuman
Zach Pennington @zachtpennington.bsky.social · 29/09/2025
Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026! @ubcpsych.bsky.social @dmcbrainhealth.bsky.social
2915729
Reposted by Tristan Shuman
The Friedman Brain Institute @sinaibrain.bsky.social · 22/09/2025
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
066
Reposted by Tristan Shuman
Zoé Christenson Wick @zoechristensonwick.bsky.social · 11/09/2025
🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
53615
Tristan Shuman @tristanshuman.bsky.social · 11/09/2025
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
1205
Reposted by Tristan Shuman
Annabelle Singer @drannabellesinger.bsky.social · 09/04/2025
Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41... By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
36530
Reposted by Tristan Shuman
Nanthia Suthana @suthanalab.bsky.social · 10/03/2025
🚨 New lab paper!🚨 A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇 www.nature.com/articles/s41...
nature.com
Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour
Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...
1028183
Reposted by Tristan Shuman
Edvard I Moser @edvardmoser.bsky.social · 03/02/2025
Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...
nature.com
Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space - Nature
A study in rats proposes a mechanism for how the brain maps the surrounding environment, including places it has never seen, by alternating left and right forward sweeps in successive theta cycles.
418758
Tristan Shuman @tristanshuman.bsky.social · 28/01/2025
New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...
Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman. 

In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.
15321
Reposted by Tristan Shuman
Holden Thorp @holdenthorp.bsky.social · 23/01/2025
My boss has been in DC a lot longer than I have - and deep inside. He has taught me a lot about how DC works. (I hope I've taught him some things about academia.). Here's what he posted on LinkedIn with our News story.
176760130
Reposted by Tristan Shuman
Lauren Vetere @laurenmvetere.bsky.social · 22/01/2025
Interested in how neural communication breaks down in a model of Alzheimer's pathology? In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6) www.biorxiv.org/content/10.1...
The title and authors of the manuscript are displayed alongside the bioRxiv lab logo and the Shuman lab logo, which features three blue overlapping oscillations.
The title is: “Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer’s disease pathology.”
The author list is: Lauren M Vetere, Angelina M Galas, Nick Vaughan, Yu Feng, Zoé Christenson Wick, Paul A Philipsberg, Olga Liobimova, Antonio Fernandez-Ruiz, and Denise J Cai.
12914
Tristan Shuman @tristanshuman.bsky.social · 22/01/2025
New preprint from the lab! @laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology! Check it out and let us know what you think.
0173
Reposted by Tristan Shuman
Lauren Vetere @laurenmvetere.bsky.social · 07/01/2025
Did 2024 feel LONG to anyone else? A little 2024 recap from me: I defended my PhD and submitted a first author paper describing my thesis work! Look out for a preprint very soon. (1/6)
Lauren stands in front of a screen showing the first slide of her thesis defense, titled "Entorhinal-hippocampal desynchronization in a mouse model of Alzheimer's Disease Pathology." Lauren's PI Tristan Shuman places a celebratory flower crown on her head while she makes a comically huge grin.
1103
Reposted by Tristan Shuman
Susanne Ahmari @ahmarilab.bsky.social · 11/12/2024
Hey #ACNP2024!!! I’ve been inspired by y’all to start a new thread to capture the amazing #FashionsOfACNP! Please add on🙏🏼💃🏻🕺 First up: the one and only @jaredwyoung.bsky.social! The shoes. The kilt. The vest. Perfection 🧑‍🍳😘
3407
Reposted by Tristan Shuman
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 05/12/2024
Thank you to NIH Director Dr. Bertagnolli for sharing our recent work in her latest blog post! I’m so proud of the team and first author @joezaki.bsky.social for all their hard work on these exciting new findings examining stress & memory-linking 🧠 Read here 👇 directorsblog.nih.gov/2024/12/05/s...
directorsblog.nih.gov
Study Suggests New Experiences Can Refresh Memories of Past Events, with Implications for Understanding PTSD
Your memories of life experiences are encoded in collections of neurons in the brain that were active at the time the event took place. Later, those same patterns of neural activity are replayed in…
0398
Reposted by Tristan Shuman
Zach Pennington @zachtpennington.bsky.social · 22/11/2024
SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!
35020
Tristan Shuman @tristanshuman.bsky.social · 22/11/2024
This is going to be a great conference! Excited to join!
071
Reposted by Tristan Shuman
Jeremy Berg @jeremymberg.bsky.social · 20/11/2024
A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n
18218109
Reposted by Tristan Shuman
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 19/11/2024
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here: www.nature.com/articles/s41...
Nature paper article with title and abstract
825990
Reposted by Tristan Shuman
SJo @sjo09.bsky.social · 15/11/2024
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture. www.sciencedirect.com/science/arti...
sciencedirect.com
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
1121062
Tristan Shuman @tristanshuman.bsky.social · 13/11/2024
Come work with us at Mount Sinai! We have an open search for tenure-track faculty in the Department of Neuroscience focusing on Computational and Systems Neuroscience. Feel free to reach out to me with questions. neuroscience.mssm.edu/docs/Faculty... Initial review will begin next week!
Now Hiring! Tenure-Track Faculty in Computational and/or Systems Neuroscience, in the Nash Family Department of Neuroscience and the Friedman Brain Institute at Mount Sinai.
02216
Reposted by Tristan Shuman
Jon Rueckemann @jonrueckemann.bsky.social · 12/11/2024
go.bsky.app/LdtUYZS I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent. Tell me who I haven’t found yet
165427
Reposted by Tristan Shuman
Rudebeck Lab @rudebecklab.bsky.social · 04/11/2024
Open faculty search at Mount Sinai in Computational and/or Systems Neuroscience. Deadline is November 15th, 2024 neuroscience.mssm.edu/pdf/faculty-...
086
Tristan Shuman @tristanshuman.bsky.social · 15/03/2024
NEW PREPRINT! Led by recent PhD Susie Feng, we characterized memory impairment and entorhinal-hippocampal desynchronization in epileptic mice. We found early hippocampal deficits and late-onset MEC deficits that emerged with progressively worse cognitive impairment. www.biorxiv.org/content/10.1...
biorxiv.org
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
1216